Effect of vitamin C on fracture healing in elderly Osteogenic Disorder Shionogi rats

Journal of Bone and Joint Surgery - Series B

Volumn 89, Issue 3, 2007, Pages 402-407

  Alcantara Martos, T ^a,e   Delgado Martinez, A D ^b   Vega, M V ^b   Carrascal, M T ^c   Munuera Martinez, L ^d  

^a HOSPITAL SAN AGUSTÍN   (Spain)

^b UNIVERSITY OF JAÉN   (Spain)

^c UNIVERSIDAD NACIONAL DE EDUCACIÓN A DISTANCIA   (Spain)

^d UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^e NONE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCORBIC ACID DEFICIENCY; BIOMECHANICS; BONE DISEASE; BONE STRENGTH; CALLUS; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFICACY; ELDERLY CARE; FEMALE; FEMUR FRACTURE; FRACTURE HEALING; HISTOPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; TORQUE; VITAMIN SUPPLEMENTATION;

ANIMALS; ASCORBIC ACID; ASCORBIC ACID DEFICIENCY; BIOMECHANICS; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; FEMALE; FEMORAL FRACTURES; FEMUR; FRACTURE HEALING; RATS; RATS, MUTANT STRAINS; STRESS, MECHANICAL; VITAMINS;

EID: 34147098623     PISSN: 0301620X     EISSN: None     Source Type: Journal    
DOI: 10.1302/0301-620X.89B3.18007     Document Type: Article

References (25)

1. Phillips CL, Yeowell HN. Vitamin C, collagen biosynthesis, and aging. In: Packer L, Fuchs J, eds. Vitamin C in health and disease. New York, USA: Marcel Dekker Inc., 1997:205-30.
2. Day SM, Ostrum RF, Chao EYS, et al. Bone injury, regeneration, and repair. In: Simon SR, ed. Orthopaedic Basic Science. 2nd ed. Rosemont, Illinois: AAOS, 2000:371-401.
3. Michelson J, Cohen A. Incidence and treatment of fractures in Thalassemia. J Orthop Trauma 1988;2:29-32.
4. Sugimoto M, Hirota S, Sato M, et al. Impaired expression of noncollagenous bone matrix protein mRNAs during fracture healing in ascorbic acid-deficient rats. J Bone Miner Res 1998;13:271-8.
5. Franceschi RT. The role of ascorbic acid in mesenchymal differentiation. Nutrition Reviews 1992;50:65-70.
6. Sullivan TA, Uschmann B, Hough R, Leboy PS. Ascorbate modulation of chondrocyte gene expression is independent of its role in collagen secretion. J Biol Chem 1994;269:22500-6.
7. Franceschi RT, Iyer BS. Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1 cells. J Bone Miner Res 1992;7:235-46.
8. Harada S, Matsumoto T, Ogata E. Role of ascorbic acid in the regulation of proliferation in osteoblast-like MC3T3-E1 cells. J Bone Miner Res 1991;6:903-8.
9. Sarisözen B, Durak K, Dincer G, Bilgen OF. The effects of vitamins E and C on fracture healing in rats. J Int Med Res 2002;30:309-13.
10. Yilmalz C, Erdemli E, Selek H, et al. The contribution of vitamin C to healing of experimental fractures. Arch Orthop Trauma Surg 2001;121:426-8.
11. Halliwell B, Gutteridge JMC, Cross CE. Free radicals, antioxidants, and human disease: where are we now? J Lab Clin Med 1992;119:598-620.
12. Halliwell B, Gutteridge JMC. The antioxidants of human extracellular fluids. Arch Biochem Biophys 1990;280:1-8.
13. Richardson TI, Ball L, Rosenfeld T. Will an orange a day keep the doctor away? Postgrad Med J 2002;78:292-4.
14. Oeffinger KC. Scurvy: more than historical relevance. Am Fam Physician 1993;48:609-13.
15. Falch JA, Mowe M, Bohmer T. Low levels of serum ascorbic acid in elderly patients with hip fracture. Scand J Clin Lab Invest 1998;58:225-8.
16. Järvinen R, Knekt P. Vitamin C, smoking and alcohol consumption. In: Packer L, Fuchs J, eds. Vitamin C in health and disease. New York: Marcel Dekker Inc, 1997:425-57.
17. Institute for Laboratory Animal Research (ILAR). http://www.nap.edu/readingroom/books/labrats (date last accessed 15 July 2006).
18. Tsunenari T, Fukase M, Fujita T. Bone histormorphometric analysis for the cause of osteopenia in vitamin C-deficient rat (ODS rat). Calcif Tissue Int 1991;48:18-27.
19. Bonnarens F, Einhorn TA. Production of a standard closed fracture in laboratory animal bone. J Orthop Res 1984;2:97-101.
20. Waynforth HB. Methods of obtaining body fluids. In: Waynforth HB, Flecknell PA, eds. Experimental and surgical technique in the rat. 2nd ed. London: Academic Press, 2001:68-99.
21. Koshiishi I, Imanari T. Measurement of ascorbate and dehydroascorbate contents in biological fluids. Anal Chem 1997;69:216-20.
22. Haleem AA, Rouse MS, Lewallen DG, et al. Gentamicin and Vancomicin do not impair experimental fracture healing. Clin Orthop 2004;427:22-4.
23. Altman R, Latta L, Keer R, et al. Effect of nonsteroidal antiinflammatory drugs on fracture healing: a laboratory study in rats. J Orthop Trauma 1995;9:392-400.
24. White AA 3rd, Panjabi MM, Southwick WO. The four biomechanical stages of fracture repair. J Bone Joint Surg [Am] 1977; 59-A:188-92.
25. Delgado-Martinez AD, Martinez ME, Carrascal MT, Rodriguez-Avial M, Munuera L. Effect of 25-OH vitamin D on fracture healing in elderly rats. J Orthop Res 1998;16:650-3.