Impaired expression of noncollagenous bone matrix protein mRNAs during fracture healing in ascorbic acid-deficient rats

Journal of Bone and Mineral Research

Volumn 13, Issue 2, 1998, Pages 271-278

  Sugimoto, Mizuo ^a   Hirota, Seiichi ^a   Sato, Motohiko ^a   Kawahata, Hirohisa ^a   Tsukamoto, Ikuyo ^b   Yasui, Natsuo ^a   Kitamura, Yukihiko ^a   Ochi, Takahiro ^a   Nomura, Shintaro ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b NARA WOMEN'S UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; COMPLEMENTARY DNA; MESSENGER RNA; OSTEOCALCIN; OSTEONECTIN; OSTEOPONTIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCORBIC ACID DEFICIENCY; BONE MATRIX; BONE MINERALIZATION; CELL DIFFERENTIATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; FEMALE; FRACTURE HEALING; GENE EXPRESSION; NONHUMAN; RAT; SCURVY; VITAMIN DEFICIENCY;

EID: 0031942734     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1998.13.2.271     Document Type: Article

References (35)

1. Bourne GH 1971 Vitamin C and Bone. In: Bourne GH (ed.) The Biochemistry and Physiology of Bone, 2nd Ed, Vol 3. Academic Press, New York, NY, U.S.A., pp. 231-279.
2. Englard S, Seifter S 1986 The biochemical functions of ascorbic acid. Ann Rev Nutr 6:365-406.
3. Padh H 1990 Cellular functions of ascorbic acid. Biochem Cell Biol 68:1166-1173.
4. Franceschi RT, Iyer BS 1992 Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1, cells. J Bone Miner Res 7:235-246.
5. Franceschi RT, Iyer BS, Cui Y 1994 Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1, cells. J Bone Miner Res 9:843-854.
6. Takeuchi Y, Nakayama K, Matsumoto T 1996 Differentiation and cell surface expression of transforming growth factor-'62 receptors are regulated by interaction with matrix collagen in murine osteoblastic cells. J Biol Chem 271:3938-3944.
7. Leboy PS, Vaias L, Uschmann B, Golub E, Adams SL, Pacifici M 1989 Ascorbic acid induces alkaline phosphatase, type X collagen, and calcium deposition in cultured chick chondrocytes. J Biol Chem 264:17281-17286.
8. Sullivan TA, Uschmann B, Hough R, Leboy PS 1994 Ascorbate modulation of chondrocyte gene expression is independent of its role in collagen secretion. J Biol Chem 269:22500-22506.
9. Nakase T, Takaoka K, Hirakawa K, Hirota S, Takemura T, Onoue H, Takebayashi K, Kitamura Y, Nomura S 1994 Alterations in the expression of osteonectin, osteopontin and osteocalcin mRNAs during the development of skeletal tissues in vivo. Bone Miner 26:109-122.
10. Luo G, D'souza R, Hogue D, Karsenty G 1995 The matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse development. J Bone Miner Res 10:325-334.
11. Hirakawa K, Hirota S, Ikeda T, Yamaguchi A, Takemura T, Nagoshi J, Yoshiki S, Suda T, Kitamura Y, Nomura S 1994 Localization of the mRNA for bone matrix proteins during fracture healing as determined by in situ hybridization. J Bone Miner Res 9:1551-1557.
12. Horio F, Ozaki K, Yoshida A. Makino S, Hayashi Y 1985 Requirement for ascorbic acid in a rat mutant unable to synthesize ascorbic acid. J Nutr 115:1630-1640.
13. Konishi T, Makino S, Mizushima Y, Harauchi T, Hasegawa Y, Yoshizaki T, Kishimoto Y, Oohara T 1990 What is the ODS rat? Historical description of the characterization studies. In: Fujita T, Fukase M, Konishi T (eds.) Vitamin C and the Scurvy-Prone ODS Rat. Elsevier, Amsterdam, The Netherlands, pp. 3-22.
14. Krane SM, Munoz AJ, Harris ED Jr 1970 Urinary polypeptides related to collagen synthesis. J Clin Invest 49:716-729.
15. Nakase T, Nomura S, Yoshikawa H, Hashimoto J, Hirota S, Kitamura Y, Oikawa S, Ono K, Takaoka K 1994 Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing. J Bone Miner Res 9:651-659.
16. Nomura S, Wills AJ, Edwards DR, Heath JK, Hogan BLM 1988 Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization. J Cell Biol 106:441-450.
17. Hirota S, Ito A, Morii E, Wanaka A, Tohyama M, Kitamura Y, Nomura S 1992 Localization of mRNA for c-kit receptor and its ligand in the brain of adult rats: An analysis using in situ hybridization histochemistry. Mol Brain Res 15:47-54.
18. Nomura S, Hirakawa K, Nagoshi J, Hirota S, Kim HM, Takemura T, Nakase T, Takaoka K, Matsumoto S, Nakajima Y, Takebayashi K, Takano-Yamamoto T, Ikeda T, Kitamura Y 1993 Method for detecting the expression of bone matrix protein by in situ hybridization using decalcified mineralized tissue. Acta Histochem Cytochem 26:303-309.
19. Hirota S, Takaoka K, Hashimoto J, Nakase T, Takemura T, Morii E, Fukuyama A, Morihana K, Kitamura Y, Nomura S 1994 Expression of mRNA of murine bone-related proteins in ectopic bone induced by murine bone morphogenetic protein-4. Cell Tissue Res 277:27-32.
20. Chen J, Singh K, Mukherjee BB, Sodek J 1993 Developmental expression of osteopontin (OPN) mRNA in rat tissues: Evidence for a role for OPN in bone formation and resorption. Matrix 13:113-123.
21. Heinegard D, Andersson G, Reinholt FP 1995 Roles of osteopontin in bone remodeling. Ann N Y Acad Sci 760:213-222.
22. Kohri K, Nomura S, Kitamura Y, Nagata T, Yoshioka K, Iguchi M, Yamate T, Umekawa T, Suzuki Y, Shinohara H, Kurita T 1993 Structure and expression of the mRNA encoding urinary stone protein (osteopontin). J Biol Chem 268: 15180-15184.
23. Hirota S, Imakita M, Kohri K, Ito A, Morii E, Adachi S, Kim HM, Kitamura Y, Nomura S 1993 Expression of osteopontin messenger RNA by macrophages in atherosclerotic plaques: A possible association with calcification. Am J Pathol 143: 1003-1008.
24. Hirota S, Ito A, Nagoshi J, Takeda M, Kurata A, Takatsuka Y, Kohri K, Nomura S, Kitamura Y 1995 Expression of bone matrix protein messenger ribonucleic acids in human breast cancers: Possible involvement of osteopontin in development of calcifying foci. Lab Invest 72:64-69.
25. Kasugai S, Zhang Q, Overall CM, Wrana JL, Butler WT, Sodek J 1991 Differential regulation of the 55 and 44 kDa forms of secreted phosphoprotein 1 (SPP-1, osteopontin) in normal and transformed rat bone cells by osteotropic hormones, growth factors and a tumor promoter. Bone Miner 13:235-250.
26. Denhardt DT, Guo X 1993 Osteopontin: A protein with diverse functions. FASEB J 7:1475-1482.
27. Sodek J, Chen J, Nagata T, Kasugai S, Todescan R Jr, Li IWS, Kim RH 1995 Regulation of osteopontin expression in osteoblasts. Ann N Y Acad Sci 760:223-241.
28. Mahmoodian F, Gosiewska A, Peterkofsky B 1996 Regulation and properties of bone alkaline phosphatase during vitamin C deficiency in guinea pigs. Arch Biochem Biophys 336:86-96.
29. McCarthy TL, Centrella M, Canalis E 1989 Regulatory effects of insulin-like growth factors I and II on bone collagen synthesis in rat calvarial cultures. Endocrinology 124:301-309.
30. Edwall D, Prisell PT, Levinovitz A, Jennische E, Norstedt G 1992 Expression of insulin-like growth factor I messenger ribonucleic acid in regenerating bone after fracture: Influence of indomethacin. J Bone Miner Res 7:207-213.
31. Andrew JG, Hoyland J, Freemont AJ, Marsh D 1993 Insulinlike growth factor gene expression in human fracture callus. Calcif Tissue Int 53:97-102.
32. Chojkier M, Spanheimer R, Peterkofsky B 1983 Specifically decreased collagen biosynthesis in scurvy dissociated from an effect on proline hydroxylation and correlated with body weight loss. J Clin Invest 72:826-835.
33. Gosiewska A, Wilson S, Kwon D, Peterkofsky B 1994 Evidence for an in vivo role of insulin-like growth factor-binding protein-1 and -2 as inhibitors of collagen gene expression in vitamin C-deficient and fasted guinea pig. Endocrinology 134: 1329-1339.
34. Peterkofsky B, Gosiewska A, Kipp DE, Shah V, Wilson S 1994 Circulating insulin-like growth factor binding proteins (IG-FBPs) 1 and 2 induced in vitamin C-deficient or fasted guinea pigs inhibit IGF-I action in cultured cells. Growth Factors 10:229-241.
35. Wilson JD 1991 Vitamin deficiency and excess. In: Wilson JD, Braunwald E, Isselbacher KJ, Petersdorf RG, Martin JB, Fauci AS, Root RK (eds.) Harrison's Principles of Internal Medicine, 12th Ed. McGraw-Hill, New York, NY, U.S.A., pp. 434-443.