Potential effects of PKC or protease inhibitors on acute pancreatitis-induced tissue injury in rats

Vascular Pharmacology

Volumn 46, Issue 6, 2007, Pages 406-411

  Shi, Changbin ^a   Zhao, Xia ^a   Wang, Xiangdong ^b   Zhao, Liming ^c   Andersson, Roland ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b FUDAN UNIVERSITY   (China)

^c Harbin First Hospital   (China)

Author keywords

Acute pancreatitis; Inhibitors; Protease; Protein kinase C

Indexed keywords

4 (2 AMINOETHYL)BENZENESULFONYL FLUORIDE; APROTININ; INTERLEUKIN 10; INTERLEUKIN 6; MYELOPEROXIDASE; PHOSPHOLIPASE A2; POLYMYXIN B; PROTEIN KINASE C INHIBITOR; PROTEINASE; PROTEINASE INHIBITOR; STAUROSPORINE; TRYPSIN INHIBITOR;

ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCITES; CATALYSIS; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVITY; LUNG INJURY; MALE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; TISSUE INJURY;

ANIMALS; APROTININ; ASCITIC FLUID; DISEASE MODELS, ANIMAL; INFLAMMATION; INTERLEUKIN-10; LUNG; MALE; NEUTROPHILS; PANCREAS; PANCREATITIS; PEPTIDE HYDROLASES; PEROXIDASE; PHOSPHOLIPASES A; POLYMYXIN B; PROTEASE INHIBITORS; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; STAUROSPORINE; SULFONES; TAURODEOXYCHOLIC ACID; TIME FACTORS; TRYPSIN INHIBITORS;

EID: 34047266356     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vph.2007.01.009     Document Type: Article

References (37)

1. Bhatia M., Saluja A.K., Hofbauer B., Lee H.S., Frossard J.L., and Steer M.L. The effects of neutrophil depletion on a completely noninvasive model of acute pancreatitis-associated lung injury. Int. J. Pancreatol. 24 (1998) 77-83
2. Cavallini G., Tittobello A., Frulloni L., Masci E., Mariana A., and Di Francesco V. Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. Gabexate in digestive endoscopy-Italian group. N. Engl. J. Med. 335 (1996) 919-923
3. Chakraborti S. Phospholipase A(2) isoforms: a perspective. Cell. Signal. 15 (2003) 637-665
4. Chakraborti S., Michael J.R., and Chakraborti T. Role of an aprotinin-sensitive protease in protein kinase C alpha-mediated activation of cytosolic phospholipase A2 by calcium ionophore (A23187) in pulmonary endothelium. Cell. Signal. 16 (2004) 751-762
5. Chen C.C., Wang S.S., Lu R.H., Chang F.Y., and Lee S.D. Serum interleukin 10 and interleukin 11 in patients with acute pancreatitis. Gut 45 (1999) 895-899
6. Ederveen A.G., Van Emst-De Vries S.E., de Pont J.J., and Willems P.H. Dissimilar effects of the protein kinase C inhibitors, staurosporine and H-7, on cholecystokinin-induced enzyme secretion from rabbit pancreatic acini. Eur. J. Biochem. 193 (1990) 291-295
7. Friess H., Shrikhande S., Riesle E., Kashiwagi M., Baczako K., Zimmermann A., Uhl W., and Buchler M.W. Phospholipase A2 isoforms in acute pancreatitis. Ann. Surg. 233 (2001) 204-212
8. Galloway S.W., and Kingsnorth A.N. Reduction in circulating levels of CD4-positive lymphocytes in acute pancreatitis: relationship to endotoxin, interleukin 6 and disease severity. Br. J. Surg. 81 (1994) 312
9. Gordge P.C., and Ryves W.J. Inhibitors of protein kinase C. Cell. Signal. 6 (1994) 871-882
10. Gukovskaya A.S., Hosseini S., Satoh A., Cheng J.H., Nam K.J., Gukovsky I., and Pandol S.J. Ethanol differentially regulates NF-kappaB activation in pancreatic acinar cells through calcium and protein kinase C pathways. Am. J. Physiol.: Gasterointest. Liver Physiol. 286 (2004) G204-G213
11. Han B., and Logsdon C.D. CCK stimulates mob-1 expression and NF-kappaB activation via protein kinase C and intracellular Ca(2+). Am. J. Physiol., Cell Physiol. 278 (2000) C344-C351
12. Hartwig W., Werner J., Jimenez R.E., Z'graggen K., Weimann J., Lewandrowski K.B., Warshaw A.L., and Fernandez-del Castillo C. Trypsin and activation of circulating trypsinogen contribute to pancreatitis-associated lung injury. Am. J. Physiol.: Gasterointest. Liver Physiol. 277 (1999) G1008-G1016
13. Hashimoto E., and Yamamura H. Further studies on the ionic strength-dependent proteolytic activation of protein kinase C in rat liver plasma membrane by endogenous trypsin-like protease. J. Biochem. (Tokyo) 106 (1989) 1041-1048
14. Hu H. Recent discovery and development of selective protein kinase C inhibitors. Drug Discov. Today 1 (1996) 438-447
15. Inoue S., Nakao A., Kishimoto W., Murakami H., Itoh K., Itoh T., Harada A., Nonami T., and Takagi H. Anti-neutrophil antibody attenuates the severity of acute lung injury in rats with experimental acute pancreatitis. Arch. Surg. 130 (1995) 93-98
16. Kruger B., Albrecht E., and Lerch M.M. The role of intracellular calcium signaling in premature protease activation and the onset of pancreatitis. Am. J. Pathol. 157 (2000) 43-50
17. Li C., Chen X., and Williams J.A. Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells. Am. J. Physiol.: Gasterointest. Liver Physiol. 287 (2004) G764-G771
18. Lin C.H., Kuan I.H., Lee H.M., Lee W.S., Sheu J.R., Ho Y.S., Wang C.H., and Kuo H.P. Induction of cyclooxygenase-2 protein by lipoteichoic acid from Staphylococcus aureus in human pulmonary epithelial cells: involvement of a nuclear factor-kappa B-dependent pathway. Br. J. Pharmacol. 134 (2001) 543-552
19. Lundberg A.H., Granger N., Russell J., Callicutt S., Gaber L.W., Kotb M., Sabek O., and Gaber A.O. Temporal correlation of tumor necrosis factor-alpha release, upregulation of pulmonary ICAM-1 and VCAM-1, neutrophil sequestration, and lung injury in diet-induced pancreatitis. J. Gastrointest. Surg. 4 (2000) 248-257
20. Makhija R., and Kingsnorth A.N. Cytokine storm in acute pancreatitis. J. Hepatobiliary. Pancreat. Surg. 9 (2002) 401-410
21. Mentula P., Kylanpaa M.L., Kemppainen E., Jansson S.E., Sarna S., Puolakkainen P., Haapiainen R., and Repo H. Plasma anti-inflammatory cytokines and monocyte human leucocyte antigen-DR expression in patients with acute pancreatitis. Scand. J. Gastroenterol. 39 (2004) 178-187
22. Osman M.O., Jacobsen N.O., Kristensen J.U., Deleuran B., Gesser B., Larsen C.G., and Jensen S.L. IT 9302, a synthetic interleukin-10 agonist, diminishes acute lung injury in rabbits with acute necrotizing pancreatitis. Surgery 124 (1998) 584-592
23. Pelagotti F., Cecchi M., Messori A., and Gabexate Mesylate Study Group. Use of gabexate mesylate in Italian hospitals: a multicentre observational study. J. Clin. Pharm. Ther. 28 (2003) 191-196
24. Poch B., Gansauge F., Rau B., Wittel U., Gansauge S., Nussler A.K., Schoenberg M., and Beger H.G. The role of polymorphonuclear leukocytes and oxygen-derived free radicals in experimental acute pancreatitis: mediators of local destruction and activators of inflammation. FEBS Lett. 461 (1999) 268-272
25. Rongione A.J., Kusske A.M., Kwan K., Ashley S.W., Reber H.A., and McFadden D.W. Interleukin 10 reduces the severity of acute pancreatitis in rats. Gastroenterology 112 (1997) 960-967
26. Saluja A.K., Bhagat L., Lee H.S., Bhatia M., Frossard J.L., and Steer M.L. Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini. Am. J. Physiol.: Gasterointest. Liver Physiol. 276 (1999) G835-G842
27. Schechtman D., and Mochly-Rosen D. Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene 20 (2001) 6339-6347
28. Siegmund E., Luthen F., Kunert J., and Weber H. Ethanol modifies the actin cytoskeleton in rat pancreatic acinar cells-comparison with effects of CCK. Pancreatology 4 (2004) 12-21
29. Singh V.P., Saluja A.K., Bhagat L., van Acker G.J., Song A.M., Soltoff S.P., Cantley L.C., and Steer M.L. Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. J. Clin. Invest. 108 (2001) 1387-1395
30. Song A.M., Bhagat L., Singh V.P., Van Acker G.G., Steer M.L., and Saluja A.K. Inhibition of cyclooxygenase-2 ameliorates the severity of pancreatitis and associated lung injury. Am. J. Physiol.: Gasterointest. Liver Physiol. 283 (2002) G1166-G1174
31. Suzuki S., Miyasaka K., Jimi A., and Funakoshi A. Induction of acute pancreatitis by cerulein in human IL-6 gene transgenic mice. Pancreas 21 (2000) 86-92
32. Uhl W., Schrag H.J., Schmitter N., Aufenanger J., Nevalainen T.J., and Buchler M.W. Experimental study of a novel phospholipase A2 inhibitor in acute pancreatitis. Br. J. Surg. 85 (1998) 618-623
33. Verme T.B., Velarde R.T., Cunningham R.M., and Hootman S.R. Effects of staurosporine on protein kinase C and amylase secretion from pancreatic acini. Am. J. Physiol. 257 (1989) G548-G553
34. Waxler B., and Rabito S.F. Aprotinin: a serine protease inhibitor with therapeutic actions: its interaction with ACE inhibitors. Curr. Pharm. Des. 9 (2003) 777-787
35. Wood J.P., and Osborne N.N. Induction of apoptosis in cultured human retinal pigmented epithelial cells: the effect of protein kinase C activation and inhibition. Neurochem. Int. 31 (1997) 261-273
36. Yedgar S., Lichtenberg D., and Schnitzer E. Inhibition of phospholipase A(2) as a therapeutic target. Biochim. Biophys. Acta 1488 (2000) 182-187
37. Yoshikawa T., Naruse S., Kitagawa M., Ishiguro H., Nakae Y., Ono T., and Hayakawa T. Effect of a new inhibitor of type II phospholipase A2 on experimental acute pancreatitis in rats. Pancreas 19 (1999) 193-198