Systems analysis of energy metabolism elucidates the affected respiratory chain complex in Leigh's syndrome

Molecular Genetics and Metabolism

Volumn 91, Issue 1, 2007, Pages 15-22

  Vo, Thuy D ^a   Paul Lee, W N ^b   Palsson, Bernhard O ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Constraint based modeling; Isotopomer analysis; Metabolic phenotyping; Nonlinear optimization; Systems biology

Indexed keywords

CARBON 13; CYTOCHROME C OXIDASE; GLUCOSE; PYRUVATE DEHYDROGENASE COMPLEX; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL CELL; ARTICLE; CAPILLARY GAS CHROMATOGRAPHY; CONTROLLED STUDY; ENERGY METABOLISM; FIBROBLAST; LEIGH DISEASE; MASS SPECTROMETRY; METABOLIC RATE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY CHAIN;

CARBON ISOTOPES; CELL LINE; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX II; ENERGY METABOLISM; FIBROBLASTS; HUMANS; LEIGH DISEASE; METABOLIC NETWORKS AND PATHWAYS; MUTATION; PYRUVATE DEHYDROGENASE COMPLEX; SUCCINATE CYTOCHROME C OXIDOREDUCTASE; TRACE ELEMENTS;

EID: 34047264333     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2007.01.012     Document Type: Article

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