Purging of the neuroblastoma stem cell compartment and tumor regression on exposure to hypoxia or cytotoxic treatment

Cancer Research

Volumn 67, Issue 6, 2007, Pages 2402-2407

  Marzi, Ilaria ^a   D'Amico, Massimo ^a   Biagiotti, Tiziana ^a   Giunti, Serena ^a   Carbone, Maria Vittoria ^a   Fredducci, David ^a   Wanke, Enzo ^b   Olivotto, Massimo ^a,c  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

^c Dipartimento di Patologia e Oncologia Sperimentali   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD133 ANTIGEN; ETOPOSIDE; PROTEIN P75; STEM CELL FACTOR;

APOPTOSIS; ARTICLE; CELL COMPARTMENTALIZATION; CELL FATE; CELL KINETICS; CELL SUBPOPULATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; NEURAL CREST; NEUROBLASTOMA; PRIORITY JOURNAL; STEM CELL; TUMOR REGRESSION;

ANOXIA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CLONE CELLS; ELECTROPHYSIOLOGY; ETOPOSIDE; HUMANS; IMMUNOHISTOCHEMISTRY; NEUROBLASTOMA; TUMOR STEM CELLS;

EID: 34047251339     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-3208     Document Type: Article

References (20)

1. Triche TJ. Neuroblastoma and other childhood neural tumors a review. Pediatr Pathol 1990;10:175-93.
2. Biagiotti T, D'Amico M, Marzi I, et al. Cell renewing in neuroblastoma: electrophysiological and immunocytochemical characterization of stem cells and derivatives. Stem Cells 2006;24:443-53.
3. Kelly DR, Joshi W. Neuroblastoma and related tumors. In: David M. Parham, editor. Pediatric neoplasia: morphology and biology. Philadelphia: Lippincott-Raven Publishers; 1996. p. 105-51.
4. Kenny AJ, O'Hare MJ, Gusterson BA. Cell-surface peptidases as modulators of growth and differentiation. Lancet 1989;2:785-7.
5. Lunney JK, Walker K, Goldman T, et al. Overview of the First International Workshop to Define Swine Leukocyte Cluster of Differentiation (CD) Antigens. Vet Immunol Immunopathol 1994;43:193-206.
6. Rodriguez-Lopez AM, Xenaki D, Eden TO, et al. MDM2 mediated nuclear exclusion of p53 attenuates etoposide-induced apoptosis in neuroblastoma cells. Mol Pharmacol 2001;59:135-43.
7. Cui H, Schroering A, Ding HF. p53 mediates DNA damaging drug-induced apoptosis through a caspase-9-dependent pathway in SH-SY5Y neuroblastoma cells. Mol Cancer Ther 2002;1:679-86.
8. Keshelava N, Zuo JJ, Chen P, et al. Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines. Cancer Res 2001;61:6185-93.
9. Graeber TG, Osmanian C, Jacks T, et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 1996;379:88-91.
10. Puppo M, Pastorino S, Melillo G, et al. Induction of apoptosis by flavopiridol in human neuroblastoma cells is enhanced under hypoxia and associated with N-myc proto-oncogene down-regulation. Clin Cancer Res 2004;10:8704-19.
11. Park SY, Billiar TR, Seol DW. Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Biochem Biophys Res Commun 2002;291:150-3.
12. Arcangeli A, Rosati B, Cherubini A, et al. Long-term exposure to retinoic acid induces the expression of IRK1 channels in HERG channel-endowed neuroblastoma cells. Biochem Biophys Res Commun 1998;244:706-11.
13. Arcangeli A, Rosati B, Cherubini A, et al. HERG-and IRK-like inward rectifier currents are sequentially expressed during neuronal development of neural crest cells and their derivatives. Eur J Neurosci 1997;9:2596-604.
14. Faravelli L, Arcangeli A, Olivotto M, et al. A HERG-like K+ channel in rat F-11 DRG cell line: pharmacological identification and biophysical characterization. J Physiol 1996;496:13-23.
15. Thomas SK, Messam CA, Spengler BA, et al. Nestin is a potential mediator of malignancy in human neuroblastoma cells. J Biol Chem 2004;279:27994-9.
16. Vaupel P. The role of hypoxia-induced factors in tumor progression. Oncologist 2004;9:10-7.
17. Jogi A, Ora I, Nilsson H, et al. Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. Proc Natl Acad Sci U S A 2002;99:7021-6.
18. Trentin A, Galvieux-Pardanaud C, Le Dourain NM, et al. Self-renewal capacity is a widespread property of various types of neural crest precursor cells. Proc Natl Acad Sci U S A 2004;101:4495-500.
19. Brodeur GM. Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer 2003;3:203-16.
20. Reya T, Morrison SJ, Clarke MF, et al. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105-11.