Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest

Pediatrics

Volumn 108, Issue 1, 2001, Pages 61-70

  Clancy, Robert R ^a,b   McGaurn, Susan A ^a,b   Goin, James E ^c   Hirtz, Deborah G ^h   Norwood, William I ^d,e   Gaynor, J William ^a,b   Jacobs, Marshall L ^f,g   Wernovsky, Gil ^a,b   Mahle, William T ^a,b   Murphy, John D ^d,e   Nicolson, Susan C ^a,b   Steven, James M ^a,b   Spray, Thomas L ^a,b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c DataMedix Corporation   (United States)

^d NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

^e THOMAS JEFFERSON UNIVERSITY   (United States)

^f ST CHRISTOPHER'S HOSPITAL FOR CHILDREN   (United States)

^g DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^h NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Allopurinol; Coma; Congenital heart defects; Free radicals; Hypoplastic left heart syndrome; Induced hypothermia; Ischemia reperfusion injury; Neuroprotective agents; Seizures; Xanthine oxidase

Indexed keywords

ALLOPURINOL; FREE RADICAL; PLACEBO;

ARTICLE; CLINICAL TRIAL; COMA; CONGENITAL HEART DISEASE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEATH; DRUG EFFICACY; DRUG HYPERSENSITIVITY; FEMALE; HEART ARREST; HEART PROTECTION; HEART SURGERY; HUMAN; HYPOPLASTIC LEFT HEART SYNDROME; INFANT; LIVER DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; NEUTROPENIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; REPERFUSION INJURY; SEIZURE; SINGLE BLIND PROCEDURE;

ALLOPURINOL; CARDIAC SURGICAL PROCEDURES; COMA; DEATH, SUDDEN, CARDIAC; FEMALE; FREE RADICAL SCAVENGERS; HEART ARREST, INDUCED; HEART DEFECTS, CONGENITAL; HUMANS; HYPOTHERMIA, INDUCED; INFANT; MALE; NEUROPROTECTIVE AGENTS; OXYGEN; SEIZURES; SINGLE-BLIND METHOD; TREATMENT OUTCOME; URIC ACID; XANTHINE OXIDASE;

EID: 17844407898     PISSN: 00314005     EISSN: None     Source Type: Journal    
DOI: 10.1542/peds.108.1.61     Document Type: Article

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