Tacrolimus for the treatment of primary sclerosing cholangitis

Liver International

Volumn 27, Issue 4, 2007, Pages 451-453

  Talwalkar, Jayant A ^a   Gossard, Andrea A ^a   Keach, Jill C ^a   Jorgensen, Roberta A ^a   Petz, Janice L ^a   Lindor, R N Keith D ^a  

^a MAYO CLINIC   (United States)

Author keywords

Sclerosing cholangitis; Therapy

Indexed keywords

ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; TACROLIMUS;

ABDOMINAL PAIN; ADULT; AGED; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTHRALGIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ATAXIA; BILIRUBIN BLOOD LEVEL; CLINICAL TRIAL; DIARRHEA; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG WITHDRAWAL; FATIGUE; FEMALE; HEARTBURN; HUMAN; MALE; NAUSEA AND VOMITING; PARESTHESIA; PHASE 2 CLINICAL TRIAL; PRIMARY SCLEROSING CHOLANGITIS; PRURITUS; TREATMENT DURATION; TREMOR;

ADULT; AGED; BILIRUBIN; CHOLANGITIS, SCLEROSING; ENZYME TESTS; FEMALE; HUMANS; MALE; MIDDLE AGED; PATIENT DROPOUTS; PILOT PROJECTS; TACROLIMUS; TREATMENT OUTCOME;

EID: 34047225352     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2007.01441.x     Document Type: Article

References (6)

1. Talwalkar JA, Lindor KD. Primary sclerosing cholangitis. Inflam Bowel Dis 2005; 11: 62-72.
2. Van Thiel DH, Carroll P, Abu-Elmagd K, et al. Tacrolimus (FK 506), A treatment for primary sclerosing cholangitis: Results of an open-label preliminary trial. Am J Gastroenterol 1995; 90: 455-9.
3. Sandborn WJ, Present DH, Isaacs KL, et al. Tacrolimus for the treatment of fistulas in patients with Crohn's disease: A randomized, placebo-controlled trial. Gastroenterology 2003; 125: 380-8.
4. Boberg KM, Fausa O, Haaland T, et al. Features of autoimmune hepatitis in primary sclerosing cholangitis: An evaluation of 114 primary sclerosing cholangitis patients according to a scoring system for the diagnosis of autoimmune hepatitis. Hepatology 1996; 23: 1369-76.
5. Kaya M, Angulo P, Lindor KD. Overlap of autoimmune hepatitis and primary sclerosing cholangitis: An evaluation of a modified scoring system. J Hepatol 2000; 33: 537-42.
6. Bo X, Broome U, Remberger M, Sumitran-Holgersson S. Tumour necrosis factor alpha impairs function of liver derived T lymphocytes and natural killer cells in patients with primary sclerosing cholangitis. Gut 2001; 49: 131-41.