Oxidative detoxication of carcinogenic 2-nitro-anisole by human, rat and rabbit cytochrome P450

Neuroendocrinology Letters

Volumn 27, Issue SUPPL. 2, 2006, Pages 9-13

  Dračínská, Helena ^a   Mikšanová, Markéta ^a   Svobodova, Martina ^a   Smrček, Stanislav ^a   Frei, Eva ^b   Schmeiser, Heinz H ^b   Stiborová, Marie ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

2 nitroanisole; Carcinogen; Cytochrome P450; Metabolism

Indexed keywords

2 ANISIDINE; 2 NITROANISOLE; 2 NITROPHENOL; 2,5 DIHYDROXYNITROBENZENE; 2,6 DIHYDROXYNITROBENZENE; ANILINE DERIVATIVE; ANISOLE DERIVATIVE; CARCINOGEN; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2E1; NITROBENZENE DERIVATIVE; RECOMBINANT ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; CARCINOGENICITY; CHILD; CONFERENCE PAPER; CONTROLLED STUDY; DEMETHYLATION; DETOXIFICATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME METABOLISM; ENZYME PURIFICATION; FEMALE; HEALTH HAZARD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; OXIDATION; PROTEIN EXPRESSION; RABBIT; RAT; SPECIES COMPARISON; TOXICOKINETICS; ULTRAVIOLET RADIATION; WESTERN BLOTTING;

EID: 34047223826     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (9)

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4. Mikšanová M, Šulc M, Rýdlová H, Schmeiser HH, Frei E, Stiborová M Enzymes involved in the metabolism of the carcinogen 2-nitroanisole: evidence for its oxidative detoxication by human cytochromes P450. Chem Res Toxicol. 2004; 17:663-71.
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7. Stiborová M, Dračínská H, Hájková J, Kadeřábková P, Frei E, Schmeiser HH, Souček P, Phillips DH, Arlt VM The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1 A1 and -1A2 and NAD(P)H:quinone oxidoreductase. Drug Metab Dispos. 2006; 34:1398-405.
8. Stiborová M, Mikšanová M, Šulc M, Rýdlová H, Schmeiser HH, Frei E. Identification of a genotoxic mechanism for the carcinogenicity of the environmental pollutant and suspected human carcinogen o-anisidine. Int J Cancer. 2005; 116:667-78.
9. Stiborová M, Mikšanová M, Smrček S, Bieler CA, Breuer A, Klokow KA, Schmeiser HH, Frei E. Identification of a genotoxic mechanism for 2-nitroanisole carcinogenicity and of its carcinogenic potential for humans. Carcinogenesis. 2004; 25:833-40.