The effect of a first-generation antihistamine on sputum viscoelasticity in cystic fibrosis

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 20, Issue 1, 2007, Pages 45-49

  Homnick, Douglas N ^b   Marks, John H ^c   Rubin, Bruce K ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c NONE

Author keywords

Antihistamine; Cyproheptadine; Cystic fibrosis; Sputum; Viscoelasticity

Indexed keywords

ANTIHISTAMINIC AGENT; CYPROHEPTADINE; PLACEBO;

ADOLESCENT; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYSTIC FIBROSIS; DOUBLE BLIND PROCEDURE; DRUG STABILITY; FOOD INTAKE; HISTAMINE RELEASE; HUMAN; LUNG INJURY; PATIENT TRANSPORT; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; SPUTUM ANALYSIS; VISCOELASTICITY;

ADOLESCENT; ADULT; APPETITE STIMULANTS; CHILD; COUGH; CYPROHEPTADINE; CYSTIC FIBROSIS; DOUBLE-BLIND METHOD; ELASTICITY; FORCED EXPIRATORY VOLUME; HISTAMINE H1 ANTAGONISTS; HUMANS; MUCOCILIARY CLEARANCE; MUCUS; PILOT PROJECTS; PLACEBOS; RHEOLOGY; SPUTUM; VISCOSITY;

EID: 34047212770     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.2006.0593     Document Type: Article

References (21)

1. Puchelle, E., O. Bajolet, and M. Abely. 2002. Airway mucus in cystic fibrosis. Paediatr. Respir. Rev. 3: 115-119.
2. King, M., and B.K. Rubin. 1994. Rheology of airway mucus. In T. Takishima and S. Shimura, eds. Airway Secretion-Physiologic Basis for the Control of Mucous Hypersecretion. Marcel Dekker, New York, 283-314.
3. Shah, P.L., S.F. Scott, R.A. Knight, C. Marriott, C. Ranasinha, and M.E. Hodson. 1996. In vivo effects of recombinant human DNase I on sputum in patients with cystic fibrosis. Thorax 51:119-125.
4. Babe, K.S., and W.E. Serafin. 1996. Histamine, bradykinin, and their antagonists. In J.G. Hardman and L.E. Limbird, eds-in-chief. Goodman and Gilman's The Pharmacological Basis of Therapeutics. McGraw-Hill, New York, 581-592.
5. Homnick, D.N., B.D. Homnick, AJ. Reeves, J.H. Marks, R.S. Pimentel, and S.K. Bonnema. 2004. Cyproheptadine is an effective appetite stimulant in cystic fibrosis. Pediatr. Pulmonol. 38:129-134.
6. Physicians Desk Reference. 2004. Periactin tablets, adverse reactions. 58th ed. Medical Economics Company, Inc., Montvale, NJ, 2051.
7. Puchelle, E., J.M. Tournier, J.M. Zahm, and P. Sadoul. 1984. Rheology of sputum collected by a simple technique limiting salivary contamination. J. Lab. Clin. Med. 103:347-353.
8. Agarwal, M., M. King, B.K. Rubin, and J.B. Shukla. 1989. Mucus transport in a miniaturized simulated cough machine; effect of constriction and serous layer stimulant. Bronchorheology 26:977-988.
9. Carayol, N., L. Crampette, B. Mainprice, P. Ben-Soussen, M. Verrecchia, J. Bousquet, and B. Lebel. 2002. Inhibition of mediator and cytokine release from dispersed nasal polyp cells by mizolastine. Allergy 57:1067-1070.
10. Schroeder, J.T., R.P. Schleimer, L.M. Lichenstein, and W. Kreutner. 2001. Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. Clin. Exp. Allergy 31:1369-1377.
11. Queralt, M., P. Brazis, M. Merlos, F. de Mora, and A. Puidgemont. 2000. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm. Res. 49:355-360.
12. Kunzelmann, K., and M. Mall. 2001. Pharmacotherapy of the ion transport defect in cystic fibrosis. Clin. Exp. Pharmacol. Physiol. 28:857-867.
13. Marin, M.G., B. Davis, and J.A. Nadel. 1977. Effect of histamine on electrical and ion transport properties of tracheal epithelium. J. Appl. Physiol. 42:735-738.
14. Liu, H., and J.M. Farley. 2005. Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport. BMC Pharmacol. 5:8.
15. 2-receptor antagonists on sputum volume and lung function in patients with generalized bronchiectasis. Br. J. Dis. Chest 79:272-274.
16. Medici, T.C., and P. Radielovic. 1979. Short-term effect of ketotifen on sputum physiochemical characteristics in chronic reversible airway disease. J. Asthma Res 17:23-30.
17. Edwards, G.F., E.H. Lewis, and D. Stafford. 1977. The effect of pholcodine with and without an antihistamine on cough and expectoration. Br. J. Dis. Chest 71:245-252.
18. Achterrath-Tuckermann, U., V. Sanno, E. Minker, F. Stroman, I. Arny, S. Joki, J. Nuutinen, I. Szeleayi. Influence of azelastine and some selected drugs on mucociliary clearance. Lung 170:201-209.
19. Merkus, F.W., and M.T. Schusler-van Hees. 1992. Influence of levocabastine suspension on ciliary beat frequency and mucociliary clearance. Allergy 47:230-233.
20. Lee, L.M., and B.S. Gendeh. 2003. Pre and post treatment mucociliary function in allergic rhinitis in three different treatment modalities. Med. J. Malaysia 58:17-20.
21. Shimura, S., T. Sasaki, H. Sasaki, and T. Takishima. 1988. Chemical properties of bronchorrhea sputum in bronchial asthma. Chest 94:1211-1215.