Multiple cellular electrophysiological effects of a novel antiarrhythmic furoquinoline derivative HA-7 [N-benzyl-7-methoxy-2,3,4,9-tetrahydrofuro[2,3-b] quinoline-3,4-dione] in guinea pig cardiac preparations

Journal of Pharmacology and Experimental Therapeutics

Volumn 316, Issue 1, 2006, Pages 380-391

  Chang, Gwo Jyh ^a   Su, Ming Jai ^b   Kuo, Sheng Chu ^c   Lin, Tsung Ping ^c   Lee, Ying Shiung ^d  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

9 BENZYL 2,3,4,9 TETRAHYDRO 7 METHOXYFURO[2,3 B]QUINOLINE 3,4 DIONE; ANTIARRHYTHMIC AGENT; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL CYCLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HEART; HEART ATRIOVENTRICULAR NODE; HEART ATRIUM FIBRILLATION; HEART PAPILLARY MUSCLE; HEART VENTRICLE FIBRILLATION; IC 50; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; WHOLE CELL;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ATRIAL FIBRILLATION; CALCIUM CHANNELS, L-TYPE; ELECTROCARDIOGRAPHY; ELECTROMYOGRAPHY; ELECTROPHYSIOLOGY; FURANS; GUINEA PIGS; HEART; HEART ATRIA; HEART CONDUCTION SYSTEM; HEART VENTRICLES; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; PAPILLARY MUSCLES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; QUINOLONES; SODIUM CHANNELS;

EID: 29244481636     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.092106     Document Type: Article

References (36)

1. Abrahamsson C, Carlsson L, and Duker G (1996) Lidocaine and nisoldipine attenuate almokalant-induced dispersion of repolarization and early afterdepolarizations in vitro. J Cardiovasc Electrophysiol 7:1074-1081.
2. Amos GJ, Abrahamsson C, Duker G, Hondeghem L, Palmer M, and Carlsson L (2001) Potassium and calcium current blocking properties of the novel antiarrhythmic agent H 345/52: implications for proarrhythmic potential. Cardiovasc Res 49:351-360.
3. + current, on repolarization in human and guinea pig ventricular myocytes. Cardiovasc Res 38:441-450.
4. Campbell TJ (1987) Cellular electrophysiological effects of D- and DL-sotalol in guinea-pig sinoatrial node, atrium and ventricle and human atrium: differential tissue sensitivity. Br J Pharmacol 90:593-599.
5. Carmeliet E (1985) Electrophysiologic and voltage clamp analysis of the effects of sotalol on isolated cardiac muscle and Purkinje fibers. J Pharmacol Exp Ther 232:817-825.
6. Chang GJ, Su MJ, Hung LM, and Lee SS (2002) Cardiac electrophysiologic and antiarrhythmic actions of a pavine alkaloid derivative, O-methyl- neocaryachine, in rat heart. Br J Pharmacol 136:459-471.
7. Echt DS, Liebson PR, Mitchel LB, Peters RW, Obias-Manno D, Barker AH, and The CAST Investigators (1991) Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med 324:781-788.
8. Ganz LI and Friedman PL (1995) Supraventricular tachycardia. N Engl J Med 332:162-173.
9. Hamill OP, Marty A, Neher E, Sakmann B, and Sigworth FJ (1981) Improved patch-clamp techniques for high resolution current recording from cells and cellfree membrane patches. Pflügers Arch Eur J Physiol 391:85-100.
10. Hohnloser SH and Woosley RL (1994) Sotalol. N Engl J Med 331:31-38.
11. Hondeghem LM and Snyders DJ (1990) Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence. Circulation 81:686-690.
12. Hume JR and Uehara A (1985) Ionic basis of the different action potential configurations of single guinea-pig atrial and ventricular myocytes. J Physiol (Lond) 368:525-544.
13. Isenberg G and Klöckner U (1982) Calcium tolerant ventricular myocytes prepared by preincubation in a "KB medium." Pflügers Arch Eur J Physiol 395:6-18.
14. Josephson IR, Sanchez-Chapula J, and Brown AM (1984) Early outward current in rat ventricular cells. Circ Res 54:157-162.
15. + current by dofetilide. Circ Res 72:75-83.
16. Kabell G, Buchanan LV, Gibson JK, and Belardinelli L (1994) Effects of adenosine on atrial refractoriness and arrhythmias. Cardiovasc Res 28:1385-1389.
17. Katritsis D and Camm AJ (1993) New class III antiarrhythmic drugs. Eur Heart J 14:93-99.
18. + current in human ventricular myocytes. Circ Res 78:689-696.
19. + channels as a mechanism of action of clofilium and d-sotalol in isolated guinea-pig ventricular heart cells. Br J Pharmacol 128:301-312.
20. Manning AS and Hearse DJ (1984) Reperfusion-induced arrhythmias: mechanism and prevention. J Mol Cell Cardiol 16:497-518.
21. Mátyus P, Varro A, Papp GJ, Wamhoff H, Varga I, and Virág L (1997) Antiarrhythmic agents: current status and perspectives. Med Res Rev 17:427-451.
22. Meijler FL, Jalife J, Beaumont J, and Vaidya D (1996) AV nodal function during atrial fibrillation: the role of electrotonic modulation of propagation. J Cardiovasc Electrophysiol 7:843-861.
23. Nattel S (2002) New ideas about atrial fibrillation 50 years on. Nature (Lond) 415:219-226.
24. Pogwizd SM and Corr PB (1987) Electrophysiologic mechanisms underlying arrhythmias due to reperfusion of ischemic myocardium. Circulation 76:404-426.
25. Sager PT, Uppal P, Follmer C, Antimisiaris M, Pruitt C, and Singh BN (1993) Frequency-dependent electrophysiologic effects of amiodarone in humans. Circulation 88:1063-1071.
26. Sanguinetti MC and Bennett PB (2003) Antiarrhythmic drug target choices and screening. Circ Res 93:491-499.
27. + current. Differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol 96:195-215.
28. Schmitt C, Brachmann J, Karch M, Waldecker B, Navarrete L, Montero M, Beyer T, and Kubler W (1991) Reverse use-dependent effects of sotalol demonstrated by recording monophasic action potentials of the right ventricle. Am J Cardiol 68:1183-1187.
29. Schram G, Pourrier M, Melnyk P, and Nattel S (2002) Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function. Circ Res 90:939-950.
30. Singh BN and Nademanee K (1985) Control of cardiac arrhythmias by selective lengthening of repolarization: theoretic considerations and clinical observations. Am Heart J 109:421-430.
31. Su MJ, Chang GJ, Wu MH, and Kuo SC (1997) Electrophysiological basis for the antiarrhythmic action and positive inotropy of HA-7, a furoquinoline alkaloid derivative, in rat heart. Br J Pharmacol 122:1285-1298.
32. Tamargo J, Caballero R, Gómez R, Valenzuela C, and Delpón E (2004) Pharmacology of cardiac potassium channels. Cardiovasc Res 62:9-33.
33. van der Hooft CS, Heeringa J, van Herpen G, Kors JA, Kingma JH, and Stricker BHC (2004) Drug-induced atrial fibrillation. J Am Coll Cardiol 44:2117-2124.
34. Waldo AL, Camm AJ, deRuyter H, Friedman PL, MacNeil DJ, Pauls JF, Pitt B, Pratt CM, Schwartz PJ, and Veltri EP (1996) Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol. Lancet 348:7-12.
35. Watanabe Y, Hara Y, Tamagawa M, and Nakaya H (1996) Inhibitory effect of amiodarone on the muscarinic acetylcholine receptor-operated potassium current in guinea pig atrial cells. J Pharmacol Exp Ther 279:617-624.
36. Yang T, Tande PM, and Refsum H (1992) Electromechanical action of dofetilide and D-sotalol during simulated metabolic acidosis in isolated guinea pig ventricular muscle. J Cardiovasc Pharmacol 20:889-894.