Activity of β3-β4 loop of the PH domain is required for the membrane targeting of SWAP-70

IUBMB Life

Volumn 59, Issue 2, 2007, Pages 99-103

  Fukui, Yasuhisa ^a   Wakamatsu, Isamu ^a   Tachikawa, Hiroyuki ^a   Okamura, Yoshihiko ^a   Tanaka, Takayuki ^a   Ihara, Sayoko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

pH domain; PI 3 kinase; Plasma membrane; PtdIns(3,4,5)P3; Ruffling; Translocation

Indexed keywords

GREEN FLUORESCENT PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HYBRID PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; SWAP 70 PROTEIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; NUCLEAR PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5-TRIPHOSPHATE; POLYPHOSPHOINOSITIDE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CONTROLLED STUDY; MUTATION; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; WILD TYPE; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT;

ANIMALS; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; DNA-BINDING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; NUCLEAR PROTEINS; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT;

EID: 34047199720     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1080/15216540701222880     Document Type: Article

References (15)

1. Sivalenka, R. R., and Jessberger, R. (2004) SWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migration. Mol. Cell. Biol. 24, 10277-10288.
2. Pearce, G., Angeli, V., Randolph, G. J., Junt, T., von Andrian, U., Schnittler, H. J., and Jessberger, R. (2006) Signaling protein SWAP-70 is required for efficient B cell homing to lymphoid organs. Nature Immunol. 7, 827-834.
3. Ihara, S., Oka, T., and Fukui, Y. (2006) Direct binding of SWAP-70 to non-muscle actin is required for membrane ruffling. J. Cell Sci. 119, 500-507.
4. 3 binding proteins. Biochim. Biophys. Acta 1402, 292-302.
5. Shinohara, M., Terada, Y., Iwamatsu, A., Shinohara, A., Mochizuki, N., Higuchi, M., Gotoh, Y., Ihara, S., Nagata, S., Itoh, H., Fukui, Y., and Jessberger, R. (2002) SWAP-70 is a guanine nucleotide exchange factor that mediates signaling of membrane ruffling. Nature 416, 759-763.
6. Borggrefe, T., Keshavarzi, S., Gross, B., Wabl, M., and Jessberger, R. (2001) Impaired IgE response in SWAP-70-deficient mice. Eur. J. Immunol. 31, 2467-2475.
7. Lemmon, M. A. (2004) Pleckstrin homology domains: not just for phosphoinositides. Biochem. Soc. Trans. 32, 707-711.
8. Maffucci, T., and Falasca, M. (2001) Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism. FEBS Lett. 506, 173-179.
9. Shaw, G. (1996) The pleckstrin homology domain: an intriguing multifunctional protein module. BioEssays 18, 35-46.
10. Wakamatsu, I., Ihara, S., and Fukui, Y. (2006) Mutational analysis on the function of the SWAP-70 PH domain. Mol. Cell. Biochem. 293, 137-145.
11. Tanaka, K., Horiguchi, K., Yoshida, T., Takeda, M., Fujisawa, H., Takeuchi, K., Umeda, M., Kato, S., Ihara, S., Nagata, S., and Fukui, Y. (1999) Evidence that a phosphatidylinositol 3,4,5-trisphosphate binding protein can function in nucleus. J. Biol. Chem. 274, 3919-3922.
12. Sato, M., Ueda, Y., Takagi, T., and Umezawa, Y. (2003) Production of PtdInsP3 at endomembranes is triggered by receptor endocytosis. Nature Cell Biol. 5, 1016-1022.
13. 2. FEBS Lett. 473, 222-226.
14. Tuzi, S., Uekama, N., Okada, M., Yamaguchi, S., Saito, H., and Yagisawa, H. (2003) Structure and dynamics of the phospholipase C-delta1 pleckstrin homology domain located at the lipid bilayer surface. J. Biol. Chem. 278, 28019-28025.
15. Rovina, P., Jaritz, M., Hofinger, S., Graf, C., Devay, P., Billich, A., Baumruker, T., and Bornancin, F. (2006) A critical beta6-beta7 loop in the pleckstrin homology domain of ceramide kinase. Biochem J. 400, 255-265.