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Volumn 28, Issue 4, 2007, Pages 865-874

Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 2;

EID: 34047176475     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgl206     Document Type: Article
Times cited : (137)

References (48)
  • 1
    • 0024151078 scopus 로고
    • Cancer Alcohol Drinking
    • International Agency for Research on In: IARC, Lyon
    • International Agency for Research on Cancer (1988) Alcohol Drinking. In: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 44. IARC, Lyon, pp. 153-246.
    • (1988) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans , vol.44 , pp. 153-246
  • 3
    • 0028557504 scopus 로고
    • Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenase in individual variation of alcohol metabolism
    • Mizoi,Y., Yamamoto,K., Ueno,Y., Fukunaga,T. and Harada,S. (1994) Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenase in individual variation of alcohol metabolism. Alcohol Alcohol., 29, 707-710.
    • (1994) Alcohol Alcohol. , vol.29 , pp. 707-710
    • Mizoi, Y.1    Yamamoto, K.2    Ueno, Y.3    Fukunaga, T.4    Harada, S.5
  • 4
    • 33744775674 scopus 로고    scopus 로고
    • Alcohol dehydrogenase 2 His47Arg polymorphism influences drinking habit independently of aldehyde dehydrogenase 2 Glu487Lys polymorphism: Analysis of 2,299 Japanese subjects
    • Matsuo,K., Wakai,K., Hirose,K., Saito,T. and Tajima,K. (2006) Alcohol dehydrogenase 2 His47Arg polymorphism influences drinking habit independently of aldehyde dehydrogenase 2 Glu487Lys polymorphism: analysis of 2,299 Japanese subjects. Cancer Epidemiol. Biomarkers Prev., 15, 1009-1013.
    • (2006) Cancer Epidemiol. Biomarkers Prev. , vol.15 , pp. 1009-1013
    • Matsuo, K.1    Wakai, K.2    Hirose, K.3    Saito, T.4    Tajima, K.5
  • 5
    • 0033361760 scopus 로고    scopus 로고
    • Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism
    • Chen,C.C., Lu,R.B., Chen,Y.C., Wang,M.F., Chang,Y.C., Li,T.K. and Yin,S.J. (1999) Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. Am. J. Hum. Genet., 65, 795-807.
    • (1999) Am. J. Hum. Genet. , vol.65 , pp. 795-807
    • Chen, C.C.1    Lu, R.B.2    Chen, Y.C.3    Wang, M.F.4    Chang, Y.C.5    Li, T.K.6    Yin, S.J.7
  • 6
    • 0032744951 scopus 로고    scopus 로고
    • Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to esophageal cancer in Japanese alcoholics
    • Yokoyama,A., Muramatsu,T., Ohmori,T., Kumagai,Y., Higuchi,S. and Ishii,H. (1999) Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to esophageal cancer in Japanese alcoholics. Alcohol. Clin. Exp. Res., 23, 1705-1710.
    • (1999) Alcohol. Clin. Exp. Res. , vol.23 , pp. 1705-1710
    • Yokoyama, A.1    Muramatsu, T.2    Ohmori, T.3    Kumagai, Y.4    Higuchi, S.5    Ishii, H.6
  • 7
    • 0345492001 scopus 로고    scopus 로고
    • Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men
    • Yokoyama,T., Yokoyama,A., Kato,H. et al. (2003) Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men. Cancer Epidemiol. Biomark. Prev., 12, 1227-1233.
    • (2003) Cancer Epidemiol. Biomark. Prev. , vol.12 , pp. 1227-1233
    • Yokoyama, T.1    Yokoyama, A.2    Kato, H.3
  • 8
    • 0037505866 scopus 로고    scopus 로고
    • Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers
    • Yokoyama,A. and Omori,T. (2003) Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers. Jpn. J. Clin. Oncol., 33, 111-121.
    • (2003) Jpn. J. Clin. Oncol. , vol.33 , pp. 111-121
    • Yokoyama, A.1    Omori, T.2
  • 9
    • 0035090650 scopus 로고    scopus 로고
    • Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics
    • Yokoyama,A., Muramatsu,T., Omori,T., Yokoyama,T., Matsushita,S., Higuchi,S., Maruyama,K. and Ishii,H. (2001) Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics. Carcinogenesis, 22, 433-439.
    • (2001) Carcinogenesis , vol.22 , pp. 433-439
    • Yokoyama, A.1    Muramatsu, T.2    Omori, T.3    Yokoyama, T.4    Matsushita, S.5    Higuchi, S.6    Maruyama, K.7    Ishii, H.8
  • 10
    • 0036848436 scopus 로고    scopus 로고
    • Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferees M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma
    • Yokoyama,A., Kato,H., Yokoyama,T. et al. (2002) Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferees M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma. Carcinogenesis, 23, 1851-1859.
    • (2002) Carcinogenesis , vol.23 , pp. 1851-1859
    • Yokoyama, A.1    Kato, H.2    Yokoyama, T.3
  • 11
    • 26244461447 scopus 로고    scopus 로고
    • Relationship between genetic polymorphisms of alcohol and aldehyde dehydrogenases and esophageal squamous cell carcinoma risk in males
    • Wu,C.F., Wu,D.C., Hsu,H.K., Kao,E.L., Lee,J.M., Lin,C.C. and Wu,M.T. (2005) Relationship between genetic polymorphisms of alcohol and aldehyde dehydrogenases and esophageal squamous cell carcinoma risk in males. World J. Gastroenterol., 11, 5103-5108.
    • (2005) World J. Gastroenterol. , vol.11 , pp. 5103-5108
    • Wu, C.F.1    Wu, D.C.2    Hsu, H.K.3    Kao, E.L.4    Lee, J.M.5    Lin, C.C.6    Wu, M.T.7
  • 13
    • 0037027753 scopus 로고    scopus 로고
    • Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population
    • Boonyaphiphat,P., Thongsuksai,P., Sriplung,H. and Puttawibul,P. (2002) Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population. Cancer Lett., 186, 193-199.
    • (2002) Cancer Lett. , vol.186 , pp. 193-199
    • Boonyaphiphat, P.1    Thongsuksai, P.2    Sriplung, H.3    Puttawibul, P.4
  • 14
    • 33646232977 scopus 로고    scopus 로고
    • Evidence for an important role of alcohol- and aldehyde metabolizing genes in cancers of the upper aerodigestive tract
    • Hashibe,M., Boffetta,P., Zaridze,D. et al. (2006) Evidence for an important role of alcohol- and aldehyde metabolizing genes in cancers of the upper aerodigestive tract. Cancer Epidemiol. Biomarkers Prev., 15, 696-703.
    • (2006) Cancer Epidemiol. Biomarkers Prev. , vol.15 , pp. 696-703
    • Hashibe, M.1    Boffetta, P.2    Zaridze, D.3
  • 15
    • 33845350410 scopus 로고    scopus 로고
    • Alcohol and aldehyde dehydrogenase gene polymorphisms and multiple cancers associated with esophageal squamous cell carcinoma in Japanese alcoholics
    • (in Japanese with English abstract)
    • Yokoyama,A., Omori,T. and Yokoyama,T. (2003) Alcohol and aldehyde dehydrogenase gene polymorphisms and multiple cancers associated with esophageal squamous cell carcinoma in Japanese alcoholics. I to Cho, 38, 339-348, (in Japanese with English abstract).
    • (2003) I to Cho , vol.38 , pp. 339-348
    • Yokoyama, A.1    Omori, T.2    Yokoyama, T.3
  • 16
    • 0036716815 scopus 로고    scopus 로고
    • Multiple cancers associated with esophageal and oropharyngolaryngeal squamous cell carcinoma and the aldehyde dehydrogenase-2 genotype in male Japanese drinkers
    • Yokoyama,A., Watanabe,H., Fukuda,H., Haneda,T., Kato,H., Yokoyama,T., Muramatsu,T., Igaki,H. and Tachimori,Y. (2002) Multiple cancers associated with esophageal and oropharyngolaryngeal squamous cell carcinoma and the aldehyde dehydrogenase-2 genotype in male Japanese drinkers. Cancer Epidemiol. Biomarkers Prev., 11, 895-900.
    • (2002) Cancer Epidemiol. Biomarkers Prev. , vol.11 , pp. 895-900
    • Yokoyama, A.1    Watanabe, H.2    Fukuda, H.3    Haneda, T.4    Kato, H.5    Yokoyama, T.6    Muramatsu, T.7    Igaki, H.8    Tachimori, Y.9
  • 17
    • 19844374583 scopus 로고    scopus 로고
    • Risk of multiple squamous cell carcinomas both in the esophagus and the head and neck region
    • Muto,M., Takahashi,M., Ohtsu,A., Ebihara,S., Yoshida,S. and Esumi,H. (2005) Risk of multiple squamous cell carcinomas both in the esophagus and the head and neck region. Carcinogenesis, 26, 1008-1012.
    • (2005) Carcinogenesis , vol.26 , pp. 1008-1012
    • Muto, M.1    Takahashi, M.2    Ohtsu, A.3    Ebihara, S.4    Yoshida, S.5    Esumi, H.6
  • 19
    • 0033990662 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 2 and glutathione S- transferase M1 polymorphism in relation to the risk for oral cancer in Japanese drinkers
    • Nomura,T., Noma,H., Shibahara,T., Yokoyama,A., Muramatsu,T. and Ohmori,T. (2000) Aldehyde dehydrogenase 2 and glutathione S- transferase M1 polymorphism in relation to the risk for oral cancer in Japanese drinkers. Oral Oncol., 36, 42-46.
    • (2000) Oral Oncol. , vol.36 , pp. 42-46
    • Nomura, T.1    Noma, H.2    Shibahara, T.3    Yokoyama, A.4    Muramatsu, T.5    Ohmori, T.6
  • 20
    • 0031709015 scopus 로고    scopus 로고
    • Alcohol-related cancers and aldehyde dehydrogenase- 2 in Japanese alcoholics
    • Yokoyama,A., Muramatsu,T., Ohmori,T. et al. (1998) Alcohol-related cancers and aldehyde dehydrogenase- 2 in Japanese alcoholics. Carcinogenesis, 19, 1383-1387.
    • (1998) Carcinogenesis , vol.19 , pp. 1383-1387
    • Yokoyama, A.1    Muramatsu, T.2    Ohmori, T.3
  • 21
    • 0022543084 scopus 로고
    • Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases and their relationship to alcohol metabolism and alcoholism
    • Bosron,W.F. and Li,T.K. (1986) Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases and their relationship to alcohol metabolism and alcoholism. Hepatology, 6, 502-510.
    • (1986) Hepatology , vol.6 , pp. 502-510
    • Bosron, W.F.1    Li, T.K.2
  • 22
    • 0027731405 scopus 로고
    • New strategy for detection of ALDH2 mutant
    • Harada,S. and Zhang,S. (1993) New strategy for detection of ALDH2 mutant. Alcohol Alcohol. 28 (Suppl), 11-13.
    • (1993) Alcohol Alcohol. , vol.28 , Issue.SUPPL. , pp. 11-13
    • Harada, S.1    Zhang, S.2
  • 23
    • 0023990035 scopus 로고
    • Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification
    • Xu,Y., Carr,L.G., Bosron,W.F. and Li,T.K. (1988) Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification. Genomics, 2, 209-214.
    • (1988) Genomics , vol.2 , pp. 209-214
    • Xu, Y.1    Carr, L.G.2    Bosron, W.F.3    Li, T.K.4
  • 24
    • 0022014717 scopus 로고
    • Allyl compounds, aldehydes, epoxides and peroxides
    • International Agency for Research on Cancer In: IARC, Lyon
    • International Agency for Research on Cancer (1985) Allyl compounds, aldehydes, epoxides and peroxides. In: IARC Monographs on the Evaluation on the Carcinogenic Risk of Chemicals to Humans. Vol. 36. IARC, Lyon, pp. 101-132.
    • (1985) IARC Monographs on the Evaluation on the Carcinogenic Risk of Chemicals to Humans , vol.36 , pp. 101-132
  • 25
    • 0031416803 scopus 로고    scopus 로고
    • Detection of DNA adducts of acetaldehyde in peripheral white blood cells of alcohol abusers
    • Fang,J.L. and Vaca,C.E. (1997) Detection of DNA adducts of acetaldehyde in peripheral white blood cells of alcohol abusers. Carcinogenesis, 18, 627-632.
    • (1997) Carcinogenesis , vol.18 , pp. 627-632
    • Fang, J.L.1    Vaca, C.E.2
  • 27
    • 0029979542 scopus 로고    scopus 로고
    • Expression and activities of class IV alcohol dehydrogenase and class III aldehyde dehydrogenase in human mouth
    • Dong,Y.J., Peng,T.K. and Yin,S.J. (1996) Expression and activities of class IV alcohol dehydrogenase and class III aldehyde dehydrogenase in human mouth. Alcohol, 13, 257-262.
    • (1996) Alcohol , vol.13 , pp. 257-262
    • Dong, Y.J.1    Peng, T.K.2    Yin, S.J.3
  • 29
    • 0021715188 scopus 로고
    • Human liver alcohol dehydrogenase: Purification and kinetic characterization of the β2β2, β2β1, αβ2 and β2γ1 'oriental' isozymes
    • Yin,S.J., Bosron,W.F., Magnes,L.J. and Li,T.K. (1984) Human liver alcohol dehydrogenase: Purification and kinetic characterization of the β2β2, β2β1, αβ2 and β2γ1 'oriental' isozymes. Biochemistry, 23, 5847-5853.
    • (1984) Biochemistry , vol.23 , pp. 5847-5853
    • Yin, S.J.1    Bosron, W.F.2    Magnes, L.J.3    Li, T.K.4
  • 31
    • 0031418672 scopus 로고    scopus 로고
    • High acetaldehyde levels in saliva after ethanol consumption: Methodological aspects and pathogenetic implication
    • Homann,N., Jousimies-Somer,H., Jokelainen,K., Heine,R. and Salaspuro,M. (1997) High acetaldehyde levels in saliva after ethanol consumption: methodological aspects and pathogenetic implication. Carcinogenesis, 18, 1739-1743.
    • (1997) Carcinogenesis , vol.18 , pp. 1739-1743
    • Homann, N.1    Jousimies-Somer, H.2    Jokelainen, K.3    Heine, R.4    Salaspuro, M.5
  • 32
    • 0343526349 scopus 로고    scopus 로고
    • High salivary acetaldehyde after a moderate dose of alcohol in ALDH2 deficient subjects: Strong evidence for local carcinogenetic action of acetaldehyde
    • Väkeväinen,S., Tillonen,J., Agarwal,D.P., Srivastava,N. and Salaspuro,M. (2000) High salivary acetaldehyde after a moderate dose of alcohol in ALDH2 deficient subjects: Strong evidence for local carcinogenetic action of acetaldehyde. Alcohol. Clin. Exp. Res., 24, 873-877.
    • (2000) Alcohol. Clin. Exp. Res. , vol.24 , pp. 873-877
    • Väkeväinen, S.1    Tillonen, J.2    Agarwal, D.P.3    Srivastava, N.4    Salaspuro, M.5
  • 34
    • 26544468034 scopus 로고    scopus 로고
    • Enhanced expression of cytochrome p450 2E1 in the oropharyngeal mucosa in alcoholics with cancer
    • [Abstract]. (abstract no. 458)
    • Baumgarten,G., Waldherr,R., Stickel,F., Simanowski,U.A., Ingelmann-Sundverg,M. and Seitz,H.K. (1996) Enhanced expression of cytochrome p450 2E1 in the oropharyngeal mucosa in alcoholics with cancer [Abstract]. Alcohol. Clin. Exp. Res., 20 (Suppl 2), 80A, (abstract no. 458).
    • (1996) Alcohol. Clin. Exp. Res. , vol.20 , Issue.SUPPL. 2
    • Baumgarten, G.1    Waldherr, R.2    Stickel, F.3    Simanowski, U.A.4    Ingelmann-Sundverg, M.5    Seitz, H.K.6
  • 35
    • 21344451677 scopus 로고    scopus 로고
    • Expression of aldehyde dehydrogenase 2 in the normal esophageal epithelium and alcohol consumption in patients with esophageal cancer
    • Morita,M., Oyama,T., Kagawa,N. et al. (2005) Expression of aldehyde dehydrogenase 2 in the normal esophageal epithelium and alcohol consumption in patients with esophageal cancer. Front. Biosci., 10, 2319-2324.
    • (2005) Front. Biosci. , vol.10 , pp. 2319-2324
    • Morita, M.1    Oyama, T.2    Kagawa, N.3
  • 36
    • 0034965647 scopus 로고    scopus 로고
    • Functional relevance of human ADH polymorphism
    • Eriksson,C.J.P., Fukunaga,T., Sarkola,T. et al. (2001) Functional relevance of human ADH polymorphism. Alcohol. Clin. Exp. Res., 25 (5 Suppl. ISBRA), 157S-163S.
    • (2001) Alcohol. Clin. Exp. Res. , vol.25 , Issue.5 SUPPL. ISBRA
    • Eriksson, C.J.P.1    Fukunaga, T.2    Sarkola, T.3
  • 37
    • 9144228670 scopus 로고    scopus 로고
    • Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer
    • Brennan,P., Lewis,S., Hashibe,M. et al. (2004) Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer. Am. J. Epidemiol., 159, 1-16.
    • (2004) Am. J. Epidemiol. , vol.159 , pp. 1-16
    • Brennan, P.1    Lewis, S.2    Hashibe, M.3
  • 38
    • 0030691111 scopus 로고    scopus 로고
    • Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers
    • Harty,L.C., Caparoso,N.E., Hayes,R.B. et al. (1997) Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers. J. Natl Cancer Inst., 89, 1698-1705.
    • (1997) J. Natl Cancer Inst. , vol.89 , pp. 1698-1705
    • Harty, L.C.1    Caparoso, N.E.2    Hayes, R.B.3
  • 39
    • 33645232958 scopus 로고    scopus 로고
    • Alcohol dehydrogenase 1*C1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers
    • Homann,N., Stickel,F., König,I.R. et al. (2006) Alcohol dehydrogenase 1*C1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers. Int. J. Cancer, 118, 1998-2002.
    • (2006) Int. J. Cancer , vol.118 , pp. 1998-2002
    • Homann, N.1    Stickel, F.2    König, I.R.3
  • 41
    • 0011409298 scopus 로고    scopus 로고
    • Calvados-related upper-intestinal tract cancer; further evidence for the local carcinogenic activity of acetaldehyde
    • [Abstract]. abstract no. 2299
    • Visapää,J.P. (2001) Calvados-related upper-intestinal tract cancer; further evidence for the local carcinogenic activity of acetaldehyde [Abstract]. Gut, 49 (Suppl 4), abstract no. 2299.
    • (2001) Gut , vol.49 , Issue.SUPPL. 4
    • Visapää, J.P.1
  • 42
    • 3843085335 scopus 로고    scopus 로고
    • Synergistic effect of alcohol drinking and smoking on in vivo acetaldehyde concentration in saliva
    • Salaspuro,V. and Salaspuro,M. (2004) Synergistic effect of alcohol drinking and smoking on in vivo acetaldehyde concentration in saliva. Int. J. Cancer, 111, 480-483.
    • (2004) Int. J. Cancer , vol.111 , pp. 480-483
    • Salaspuro, V.1    Salaspuro, M.2
  • 44
    • 33745161859 scopus 로고    scopus 로고
    • Association between fruit and vegetable consumption and oral cancer: A meta-analysis of observational studies
    • Pavia,M., Pileggi,C., Nobile,C.G and Angellio,I.F. (2006) Association between fruit and vegetable consumption and oral cancer: A meta-analysis of observational studies. Am. J. Clin. Nutr., 83, 1126-1134.
    • (2006) Am. J. Clin. Nutr. , vol.83 , pp. 1126-1134
    • Pavia, M.1    Pileggi, C.2    Nobile, C.G.3    Angellio, I.F.4
  • 45
    • 0030963846 scopus 로고    scopus 로고
    • DNA damage, DNA repair, and alcohol toxicity-a review
    • Brooks,P.J. (1997) DNA damage, DNA repair, and alcohol toxicity-a review. Alcohol. Clin. Exp. Res., 21, 1073-1082.
    • (1997) Alcohol. Clin. Exp. Res. , vol.21 , pp. 1073-1082
    • Brooks, P.J.1
  • 47
    • 17444426291 scopus 로고    scopus 로고
    • Epidemiological evidence that acetaldehyde plays a significant role in the development of decreased serum folate concentration and elevated mean corpuscular volume in alcohol drinkers
    • Yokoyama,T., Saito,K., Lwin,H., Yoshiike,N., Saito,K., Yamamoto,A., Matsushita,Y., Date,C. and Tanaka,H. (2005) Epidemiological evidence that acetaldehyde plays a significant role in the development of decreased serum folate concentration and elevated mean corpuscular volume in alcohol drinkers. Alcohol. Clin. Exp. Res., 29, 622-630.
    • (2005) Alcohol. Clin. Exp. Res. , vol.29 , pp. 622-630
    • Yokoyama, T.1    Saito, K.2    Lwin, H.3    Yoshiike, N.4    Saito, K.5    Yamamoto, A.6    Matsushita, Y.7    Date, C.8    Tanaka, H.9
  • 48
    • 0024499678 scopus 로고
    • Cleavage of folates during ethanol metabolism. Role of acetaldehyde/xanthine oxidase-generated superoxide
    • Shaw,S., Jayatilleke,E., Herbert,V. and Colman,N. (1989) Cleavage of folates during ethanol metabolism. Role of acetaldehyde/xanthine oxidase-generated superoxide. Biochem. J., 257, 277-280.
    • (1989) Biochem. J. , vol.257 , pp. 277-280
    • Shaw, S.1    Jayatilleke, E.2    Herbert, V.3    Colman, N.4


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