Effects of acute and weekly episodic exposures to anatoxin-a on the motor activity of rats: Comparison with nicotine

Toxicology

Volumn 234, Issue 1-2, 2007, Pages 83-89

  MacPhail, R C ^a   Farmer, J D ^a   Jarema, K A ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Anatoxin a; Episodic exposure; Motor activity; Nicotine; Rat

Indexed keywords

ANATOXIN A; NICOTINE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYANOBACTERIUM; EXPOSURE; ISOMER; MALE; MOTOR ACTIVITY; NERVOUS SYSTEM; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIZATION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; GANGLIONIC STIMULANTS; INJECTIONS, SUBCUTANEOUS; MALE; MOTOR ACTIVITY; NICOTINE; NICOTINIC AGONISTS; RATS; RATS, LONG-EVANS; STEREOISOMERISM; TIME FACTORS; TROPANES;

CYANOBACTERIA; RATTUS;

EID: 34047167869     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.02.001     Document Type: Article

References (37)

1. Adeyemo O.M., and Siren A.L. Cardio-respiratory changes and mortality in the conscious rat induced by (+)- and (+/-)-anatoxin-a. Toxicon. 30 (1992) 899-905
2. Azevedo S.M.F.O., Chernoff N., Falconer I.R., Gage M., Hilborn E.D., Hooth M.J., Jensen K., MacPhail R., Rogers E., Shaw G.R., and Stewart I. Health effects of harmful cyanobacterial blooms. In: Hudnell H.K. (Ed). Advances in Experimental Medicine and Biology (2007), Springer Press, New York
3. Booze R.M., Welch M.A., Wood M.L., Billings K.A., Apple S.R., and Mactutus C.F. Behavioral sensitization following repeated intravenous nicotine administration: gender differences and gonadal hormones. Phamacol. Biochem. Behav. 64 (1999) 827-839
4. Carmichael W.W. The toxins of cyanobacteria. Sci. Am. 270 (1994) 78-86
5. Carmichael W.W. Health effects of toxin-producing cyanobacteria: "the cyanoHABs. Hum. Ecol. Risk Assess. 7 (2001) 1393-1407
6. Carmichael W.W., Biggs D.F., and Gorham P.R. Toxicology and pharmacological action of anabena flos-aquae toxin. Science 187 (1975) 542-544
7. Carmichael W.W., and Falconer I.R. Diseases related to freshwater blue-green algal toxins, and control measures. In: Falconer I.R. (Ed). Algal Toxins in Seafood and Drinking Water (1993), Academic Press, New York 187-209
8. Chorus I., and Bartram J. Toxic Cyanobacteria in Water: A Guide to Their Public Health Consequences Monitoring and Management (1999), E & FN Spon, New York
9. Clarke P.B.S., and Kumar R. The effects of nicotine on locomotor activity in non-tolerant and tolerant rats. Br. J. Pharmacol. 78 (1983) 329-337
10. Codd G.A., Morrison L.F., and Metcalf J.S. Cyanobacterial toxins: risk management for health protection. Toxicol. Appl. Pharmacol. 203 (2005) 264-272
11. Cox P.A., Banack S.A., Murch S.J., Rasmussen U., Tien G., Bidigare R.R., Metcalf J.S., Morrison L.F., Codd G.A., and Bergman B. Diverse taxa of cyanobacteria produce B-N-methylamino-l-alanine, a neurotoxic amino acid. Proc. Natl. Acad Sci. U.S.A. 102 (2005) 5074-5078
12. Daly J.W. Nicotinic agonists, antagonists, and modulators from natural sources. Cell. Mol. Neurobiol. 25 (2005) 513-552
13. Damaj M.I., and Flores C.M. Nicotinic cholinergic receptors as targets in pain control. In: Levin E.D. (Ed). Nicotinic Receptors in the Nervous System (2002), CRC Press, New York 113-141
14. Fawell J.K., Mitchell R.E., Hill R.E., and Everett D.J. The toxicity of cyanobacterial toxins in the mouse: II Anatoxin-a. Hum. Exp. Toxicol. 18 (1999) 168-173
15. Flores C.M., Rogers S.W., Pabreza L.A., Wolfe B.B., and Kellar K.J. A subtype of nicotinic cholinergic receptor in rat brain is composed of a4 and B2 subunits and is up-regulated by chronic nicotine treatment. Mol. Pharmacol. 41 (1992) 31-37
16. Gordon C.J., Rowsey P.J., and Yang Y.L. Effect of repeated nicotine exposure on core temperature and motor activity in male and female rats. J. Therm. Biol. 27 (2002) 485-492
17. Grottick A.J., Trube G., Corrigall W.A., Huwyler J., Malherbe P., Wyler R., and Higgins G.A. Evidence that nicotinic a7 receptors are not involved in the hyperlocomotor and rewarding effects of nicotine. J. Pharmacol. Exp. Ther. 294 (2000) 1112-1119
18. Haider S., Naithani V., Viswanathan P., and Kakkar P. Cyanobacterial toxins: a growing environmental concern. Chemosphere 52 (2003) 1-21
19. HARRNESS. In: Ramsdell J.S., Anderson D.M., and Gilbert P.M. (Eds). Harmful Algal Research and Response: A National Environmental Strategy 2005-2015 (2005), Ecological Society of America, Washington, DC 1-96
20. Kanyt L., Stolerman I.P., Chandler C.J., Saigusa T., and Pogun S. Influence of sex and female hormones on nicotine-induced changes in locomotor activity in rats. Pharmacol. Biochem. Behav. 62 (1999) 179-187
21. Kofuji P., Aracava Y., Swanson K.L., Aronstam R.S., Rapoport H., and Alburquerque E.X. Activation and blockade of the acetylcholine receptor-ion channel by the agonists (+)-anatoxin-a, the N-methyl derivative and the enantiomer. J. Pharmacol. Exp. Ther. 252 (1990) 517-525
22. Ksir C., Hakan R.L., and Kellar K.J. Chronic nicotine and locomotor activity: influences of exposure dose and test dose. Psychopharmacol 92 (1987) 25-29
23. MacPhail, R.C., Farmer, J.D., Jarema, K.A. Sensitization and tolerance with episodic (weekly) nicotine on motor activity in rats. Neurotoxicol. Teratol., doi:10.1016/j.ntt.2006.11.012, in press.
24. MacPhail R.C., and Jarema K.A. Prospects on behavioral studies of marine and freshwater toxins. Neurotoxicol. Teratol. 27 (2005) 695-699
25. Menzaghi F., Whelan K.T., Risbrough V.B., Rao T.S., and Lloyd G.K. Effects of a novel cholinergic ion channel agonist SIB-1765F on locomotor activity in rats. J. Pharmacol. Exp. Ther. 280 (1997) 384-392
26. Miller D., Wilkins L., Bardo M., Crooks P., and Dwoskin L. Once weekly administration of nicotine produces long-lasting locomotor sensitization in rats via a nicotinic receptor-mediated mechanism. Psychopharmacology 156 (2001) 469-476
27. Paerl H.W., Fulton R.S., Moisander P.H., and Dyble J. Harmful freshwater algal blooms, with an emphasis on cyanobacteria. Sci. World 1 (2001) 76-113
28. Patocka J., and Stredab L. Brief review of natural nonprotein neurotoxins. ASA Newslett. 89 (2002) 16-23
29. Potter A., and Newhouse P.A. Clinical methodologies in the examination of nicotinic effects on cognition. In: Levin E.D. (Ed). Nicotinic Receptors in the Nervous System (2002), CRC Press, New York 261-277
30. Spivak C.E., Witkop B., and Albuqueruqe E.X. Anatoxin-a: A novel, potent agonist at the nicotinic receptor. Mol. Pharmacol. 18 (1980) 384-394
31. Stolerman I.P. Inter-species consistency in the behavioral pharamacology of nicotine dependence. Behav. Pharmacol. 10 (1999) 559-580
32. Stolerman I.P., Albuquerque E.X., and Garcha H.S. Behavioural effects of anatoxin, a potent nicotinic agonist, in rats. Neuropharmacol. 31 (1992) 311-314
33. Stolerman I.P., Fink R., and Jarvik M.E. Acute and chronic tolerance to nicotine measured by activity in rats. Psychopharmacology 30 (1973) 329-342
34. Swanson K.L., Allen C.N., Aronstam R.S., Rapoport H., and Albuquerque E.X. Molecular mecanisms of the potent and stereospecific nicotinic receptor agonist (+)-anatoxin-a. Mol. Pharmacol. 29 (1986) 250-257
35. Thomas P., Stephens M., Wilkie G., Amar M., Lunt G.G., Whiting P., Gallagher T., Pereira E., Alkondon M., Albuquerque E.X., and Wonnacott S. (+)-Anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors. J. Neurochem. 60 (1993) 2308-2311
36. 3H]nicotine binding by the enantiomers of nicotine, nornicotine and anatoxin-a in membranes and solubilized preparations of different brain regions of rat. Naunyn-Schmiedeberg's Arch. Pharmacol. 348 (1993) 28-34
37. Zhang X., Stjernlof P., and Nordberg A. Anatoxin-a a potent ligand for nicotinic cholinergic receptors in rat brain. Eur. J. Pharmacol. 135 (1987) 457-458