Clinicopathological significance of aminopeptidase N/CD13 expression in human gastric carcinoma

Hepato-Gastroenterology

Volumn 54, Issue 73, 2007, Pages 36-40

  Kawamura, Junichiro ^a   Shimada, Yutaka ^a,d   Kitaichi, Hidenori ^b   Komoto, Izumi ^a,e   Hashimoto, Yosuke ^a   Kaganoi, Junichi ^a   Miyake, Masayuki ^c   Yamasaki, Seiji ^a   Kondo, Kan ^a   Imamura, Masayuki ^a,e  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

^c Kitano Hospital   (Japan)

^d HYOGO COLLEGE OF MEDICINE   (Japan)

^e Osaka Saiseikai Noe Hospital   (Japan)

Author keywords

Aminopeptidase N (APN) CD13; Bestatin; Gastric cancer; Immunohistochemistry; Tumor invasion and metastasis

Indexed keywords

MICROSOMAL AMINOPEPTIDASE; MONOCLONAL ANTIBODY;

ADULT; AGED; ARTICLE; CANCER SURGERY; CANCER SURVIVAL; CANCER TISSUE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STOMACH CARCINOMA;

AGED; ANTIGENS, CD13; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; STOMACH NEOPLASMS;

EID: 34047143135     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Werner M, Becker KF, Keller G, Hofler H: Gastric adenocarcinoma: pathomorphology and molecular pathology. J Cancer Res Clin Oncol 2001; 127:207-216.
2. Quaroni A, Nichols BL, Quaroni E, Hurst K, Herrera L, Weiser MM, Hamilton SR: Expression and different polarity of aminopeptidase N in normal human colonic mucosa and colonic tumors. Int J Cancer 1992; 51:404-411.
3. Real FX, Xu M, Vila MR, de Bolos C: Intestinal brush-border-associated enzymes: co-ordinated expression in colorectal cancer. Int J Cancer 1992; 51:173-181.
4. Moore JH, Lesser EJ, Erdody DH, Natale RB, Orringer MB, Beer DG: Intestinal differentiation and p53 gene alterations in Barrett's esophagus and esophageal adenocarcinoma. Int J Cancer 1994; 56:487-493.
5. Menrad A, Speicher D, Wacker J, Herlyn M: Biochemical and functional characterization of aminopeptidase N expressed by human melanoma cells. Cancer Res 1993; 53:1450-1455.
6. Umezawa H: New microbial secondary metabolites under preclinical development for cancer treatment. Recent Results Cancer Res 1978; 63:120-134.
7. Umezawa H: Recent studies on antibiotics and small molecular immunomodulators with potential usefulness in treating lung cancer: Part II - Small molecular weight immunomodulators produced by microorganisms. Int J Clin Pharmacol Ther Toxicol 1982; 20:19-23.
8. Blomgren H, Esposti PL, Naslund I, Johansen L, Lemming O: Adjuvant bestatin (Ubenimex) treatment following full-dose local irradiation for bladder carcinoma. Acta Oncol 1990; 29:809-812.
9. Mouritzen C: Bestatin as adjuvant treatment in operated stage I and stage II non- small cell lung cancer. European Lung Cancer Study Group. Acta Oncol 1990; 29:817-820.
10. Ota K, Ogawa N: Randomized controlled study of chemoim munotherapy with bestatin of acute nonlymphocytic leukemia in adults. Biomed Pharmacother 1990; 44:93-101.
11. Yasumitsu T, Ohshima S, Nakano N, Kotake Y, Tominaga S: Bestatin in resected lung cancer. A randomized clinical trial. Acta Oncol 1990; 29:827-831.
12. Niimoto M, Hattori T: Prospective randomized controlled study on bestatin in resectable gastric cancer. Biomed Pharmacother 1991; 45:121-124.
13. Sobin L, Wittekind C: TNM classification of malignant tumors. 5th Edition. In: Stomach. New York, Wiley-Liss, Inc. 1997; pp. 59-62.
14. Hashida H, Takabayashi A, Kanai M, Adachi M, Kondo K, Kohno N, Yamaoka Y, Miyake M: Aminopeptidase N is in-volved in cell motility and angiogenesis: its clinical significance in human colon cancer. Gastroenterology 2002; 122:376-386.
15. Osborn M, Mazzoleni G, Santini D, Marrano D, Martinelli G, Weber K: Villin, intestinal brush border hydrolases and keratin polypeptides in intestinal metaplasia and gastric cancer; an immunohistologic study emphasizing the different degrees of intestinal and gastric differentiation in signet ring cell carcinomas. Virchows Arch A Pathol Anat Histopathol 1988; 413:303-312.
16. Bogenrieder T, Finstad CL, Freeman RH, Papandreou CN, Scher HI, Albino AP, Reuter VE, Nanus DM: Expression and localization of aminopeptidase A, aminopeptidase N, and dipeptidyl peptidase IV in benign and malignant human prostate tissue. Prostate 1997; 33:225-232.
17. Ishii K, Usui S, Yamamoto H, Sugimura Y, Tatematsu M, Hirano K: Decreases of metallothionein and aminopeptidase N in renal cancer tissues. J Biochem (Tokyo) 2001; 129:253-258.
18. Sobol RE, Mick R, Royston I, Davey FR, Ellison RR, Newman R, Cuttner J, Griffin JD, Collins H, Nelson DA, et al: Clinical importance of myeloid antigen expression in adult acute lymphoblastic leukemia N Engl J Med 1987; 316:1111-1117.
19. Fujii H, Nakajima M, Saiki I, Yoneda J, Azuma I, Tsuruo T: Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13. Clin Exp Metastasis 1995; 13:337-344.
20. Saiki I, Fujii H, Yoneda J, Abe F, Nakajima M, Tsuruo T, Azuma I: Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation. Int J Cancer 1993; 54:137-143.
21. Ino K, Goto S, Okamoto T, Nomura S, Nawa A, Isobe K, Mizutani S, Tomoda Y: Expression of aminopeptidase N on human choriocarcinoma cells and cell growth suppression by the inhibition of aminopeptidase N activity. Jpn J Cancel Res 1994; 85:927-933.
22. Saiki I, Murata J, Watanabe K, Fujii H, Abe F, Azuma I: Inhibition of tumor cell invasion by ubenimex (bestatin) in vitro. Jpn J Cancer Res 1989; 80:873-878.
23. Iwahashi M, Tanimura H, Yamaue H, Tani M, Noguchi K, Mizobata S, Tsunoda T, Tamai M, Hotta T, Arii K, et al: Ubenimex treatment enhances the susceptibility of gastric cancer cell lines to lymphokine-activated killer cells. Anticancer Res 1994; 14:1563-1568.