Hypoxemic reperfusion exacerbates the neurological injury sustained during neonatal deep hypothermic circulatory arrest: a model of cyanotic surgical repair

European Journal of Cardio-thoracic Surgery

Volumn 31, Issue 5, 2007, Pages 907-915

  Hickey, Edward J ^a,b   You, Xiaomang ^a   Kaimaktchiev, Vassil ^a   Ungerleider, Ross M ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Cardiopulmonary bypass; Cerebral protection; Congenital; Cyanotic

Indexed keywords

ACID; BASE;

ACID BASE BALANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL OXYGEN TENSION; ARTICLE; ARTIFICIAL VENTILATION; BRAIN EDEMA; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN NECROSIS; BRAIN PERFUSION; CARDIOPULMONARY BYPASS; CELL LOSS; CONTROLLED STUDY; CYANOTIC HEART DISEASE; DEEP HYPOTHERMIC CIRCULATORY ARREST; DISEASE EXACERBATION; DISEASE SEVERITY; HISTOPATHOLOGY; HYPOXEMIA; INOTROPISM; MEAN ARTERIAL PRESSURE; MEDICAL PARAMETERS; NERVE CELL LESION; NEWBORN; NEWBORN PERIOD; NONHUMAN; OPERATION DURATION; OXYGENATION; PIGLET; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RANDOMIZATION; REPERFUSION; SCORING SYSTEM; SURGICAL RISK; SURVIVAL; WARMING; ANIMAL; BRAIN; BRAIN CIRCULATION; DISEASE MODEL; FLUORESCENCE MICROSCOPY; HEART MUSCLE REPERFUSION; METHODOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SWINE;

ANIMALS; ANIMALS, NEWBORN; ANOXEMIA; BRAIN; BRAIN ISCHEMIA; CARDIOPULMONARY BYPASS; CEREBROVASCULAR CIRCULATION; CIRCULATORY ARREST, DEEP HYPOTHERMIA INDUCED; DISEASE MODELS, ANIMAL; MICROSCOPY, FLUORESCENCE; MYOCARDIAL REPERFUSION; SWINE;

EID: 34047126431     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcts.2007.01.006     Document Type: Article

References (28)

1. Molina J.E., Einzig S., Mastri A.R., Bianco R.W., Marks J.A., Rasmussen T.M., and Clack R.M. Brain damage in profound hypothermia. Perfusion versus circulatory arrest. J Thorac Cardiovasc Surg 87 4 (1984) 596-604
2. Wypij D., Newburger J.W., Rappaport L.A., duPlessis A.J., Jonas R.A., Wernovsky G., Lin M., and Bellinger D.C. The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: the Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg 126 5 (2003) 1397-1403
3. Langley S.M., Chai P.J., Tsui S.S., Jaggers J.J., and Ungerleider R.M. The effects of a leukocyte-depleting filter on cerebral and renal recovery after deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg 119 6 (2000) 1262-1269
4. Rimpilainen J., Pokela M., Kiviluoma K., Anttila V., Vainionpää V., Hirvonen J., Ohtonen P., Mennander A., Remes E., and Juvonen T. Leukocyte filtration improves brain protection after a prolonged period of hypothermic circulatory arrest: a study in a chronic porcine model. J Thorac Cardiovasc Surg 120 6 (2000) 1131-1141
5. del Zoppo G.J., Schmid-Schonbein G.W., Mori E., Copeland B.R., and Chang C.M. Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke 22 10 (1991) 1276-1283
6. Hossmann K.A. Reperfusion of the brain after global ischemia: hemodynamic disturbances. Shock 8 2 (1997) 95-101 discussion 2-3
7. Jones Jr. M.D., Traystman R.J., Simmons M.A., and Molteni R.A. Effects of changes in arterial O2 content on cerebral blood flow in the lamb. Am J Physiol 240 2 (1981) H209-H215
8. Borgstrom L., Johannsson H., and Siesjo B.K. The relationship between arterial po2 and cerebral blood flow in hypoxic hypoxia. Acta Physiol Scand 93 3 (1975) 423-432
9. Johannsson H., and Siesjo B.K. Cerebral blood flow and oxygen consumption in the rat in hypoxic hypoxia. Acta Physiol Scand 93 2 (1975) 269-276
10. O'Rourke M.M., Nork K.M., and Kurth C.D. Altered brain oxygen extraction with hypoxia and hypotension following deep hypothermic circulatory arrest. Acta Neurochir Suppl 70 (1997) 78-79
11. Kirshbom P.M., Jacobs M.T., Tsui S.S., DiBernardo L.R., Schwinn D.A., Ungerleider R.M., and Gaynor J.W. Effects of cardiopulmonary bypass and circulatory arrest on endothelium-dependent vasodilation in the lung. J Thorac Cardiovasc Surg 111 6 (1996) 1248-1256
12. Tsui S.S., Kirshbom P.M., Davies M.J., Jacobs M.T., Kern F.H., Gaynor J.W., Greeley W.J., and Ungerleider R.M. Thromboxane A2-receptor blockade improves cerebral protection for deep hypothermic circulatory arrest. Eur J Cardiothorac Surg 12 2 (1997) 228-235
13. Tsui S.S., Kirshbom P.M., Davies M.J., Jacobs M.T., Greeley W.J., Kern F.H., Gaynor J.W., and Ungerleider R.M. Nitric oxide production affects cerebral perfusion and metabolism after deep hypothermic circulatory arrest. Ann Thorac Surg 61 6 (1996) 1699-1707
14. O'Rourke M.M., Nork K.M., and Kurth C.D. Neonatal cerebral oxygen regulation after hypothermic cardiopulmonary bypass and circulatory arrest. Crit Care Med 28 1 (2000) 157-162
15. Tsui S.S., Schultz J.M., Shen I., and Ungerleider R.M. Postoperative hypoxemia exacerbates potential brain injury after deep hypothermic circulatory arrest. Ann Thorac Surg 78 1 (2004) 188-196 discussion -96
16. Schmued L., Albertson C., and Slikker W. Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Research 751 (1997) 37-46
17. Cammermeyer J. The importance of avoiding the "dark" neurons in experimental neuropathology. Acta Neuropathol 1 (1961) 245-270
18. Martin L.J., Sieber F.E., and Traystman R.J. Apoptosis and necrosis occur in separate neuronal populations in hippocampus and cerebellum after ischemia and are associated with differential alterations in metabotropic glutamate receptor signaling pathways. J Cereb Blood Flow Metab 20 1 (2000) 153-167
19. Leffler C., Busija D., Mirro R., Armstead W., and Beasley D. Effects of ischemia on brain blood flow and oxygen consumption. Am J Physiol 257 pt6 (1989) H1917-H1926
20. Armstead W., Mirro R., Zuckerman S., Shibata M., and Leffler C. Transforming growth factor-beta attenuates ischemia-induced alterations in cerebrovascular response. Am J Physiol 264 pt2 (1993) H381-H385
21. Bottiger B.W., Krumnikl J.J., Gass P., Schmitz B., Motsch J., and Martin E. The cerebral 'no-reflow' phenomenon after cardiac arrest in rats-influence of low-flow reperfusion. Resuscitation 34 1 (1997) 79-87
22. Langley S.M., Chai P.J., Miller S.E., Mault J.R., Jaggers J.J., Tsui S.S., Lodge A.J., Lefurgey A., and Ungerleider R.M. Intermittent perfusion protects the brain during deep hypothermic circulatory arrest. Ann Thorac Surg 68 1 (1999) 4-12 discussion -3
23. Priestley M.A., Golden J.A., O'Hara I.B., McCann J., and Kurth C.D. Comparison of neurologic outcome after deep hypothermic circulatory arrest with alpha-stat and pH-stat cardiopulmonary bypass in newborn pigs. J Thorac Cardiovasc Surg 121 2 (2001) 336-343
24. Shum-Tim D., Nagashima M., Shinoka T., Bucerius J., Nollert G., Lidov H.G., Laussen P.C., and Jonas R.A. Postischemic hyperthermia exacerbates neurologic injury after deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg 116 5 (1998) 780-792
25. Ye J., Yang L., Del Bigio M.R., Filgueiras C.L., Ede M., Summers R., Salerno T.A., and Deslauriers R. Neuronal damage after hypothermic circulatory arrest and retrograde cerebral perfusion in the pig. Ann Thorac Surg 61 5 (1996) 1316-1322
26. Corno A.F., Milano G., Samaja M., Tozzi P., and von Segesser L.K. Chronic hypoxia: a model for cyanotic congenital heart defects. J Thorac Cardiovasc Surg 124 1 (2002) 105-112
27. Mault J.R., Ohtake S., Klingensmith M.E., Heinle J.S., Greeley W.J., and Ungerleider R.M. Cerebral metabolism and circulatory arrest: effects of duration and strategies for protection. Ann Thorac Surg 55 1 (1993) 57-63 discussion -4
28. Nollert G., Nagashima M., Bucerius J., Shin'oka T., Lidov H.G., du Plessis A., and Jonas R.A. Oxygenation strategy and neurologic damage after deep hypothermic circulatory arrest. II. hypoxic versus free radical injury. J Thorac Cardiovasc Surg 117 6 (1999) 1172-1179