Nitric oxide production affects cerebral perfusion and metabolism after deep hypothermic circulatory arrest

Annals of Thoracic Surgery

Volumn 61, Issue 6, 1996, Pages 1699-1707

  Tsui, Steven S L ^a,b   Kirshbom, Paul M ^a   Davies, Michael J ^a   Jacobs, Michael T ^a   Greeley, William J ^a   Kern, Frank H ^a   Gaynor, J William ^a   Ungerleider, Ross M ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b PAPWORTH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; BRAIN CIRCULATION; BRAIN OXYGEN CONSUMPTION; BRAIN PERFUSION; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; HEART ARREST; INDUCED HYPOTHERMIA; INTRAARTERIAL DRUG ADMINISTRATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SWINE; SYSTEMIC VASCULAR RESISTANCE; WARMING;

EID: 0029996676     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/0003-4975(96)00197-X     Document Type: Article

References (22)

1. Newburger JW, Jonas RA, Wernovsky G, et al. A comparison of the perioperative neurologic effects of hypothermic circulatory arrest versus low-flow cardiopulmonary bypass in infant heart surgery. N Engl J Med 1993;329:1057-64.
2. Bellinger D, Jonas R, Rappaport L, et al. Developmental and neurologic status of children after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary by-pass. N Engl J Med 1995;332:549-55.
3. Greeley WJ, Ungerleider RM, Kern FH, Brusino FG, Smith LR, Reves JG. Effects of cardiopulmonary bypass on cerebral blood flow in neonates, infants, and children. Circulation 1989;80(Suppl 1):209-15.
4. Greeley WJ, Kern FH, Ungerleider RM, et al. The effects of hypothermic cardiopulmonary bypass and total circulatory arrest on cerebral metabolism in neonates, infants, and children. J Thorac Cardiovasc Surg 1991;101:783-94.
5. Mault JR, Ohtake S, Klingensmith ME, Heinle JS, Greeley WJ, Ungerleider RM. Cerebral metabolism and circulatory arrest: effects of duration and strategies for protection. Ann Thorac Surg 1993;55:57-64.
6. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6.
7. Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988; 333:664-6.
8. Iadecola C, Pelligrino DA, Moskowitz MA, Lassen NA. Nitric oxide synthase inhibition and cerebrovascular regulation. J Cereb Blood Flow Metab 1994;14:175-92.
9. Meadow W, Rudinsky B, Bell A, Lozon M, Randle C, Hipps R. The role of prostaglandins and endothelium-derived relaxation factor in the regulation of cerebral blood flow and cerebral oxygen utilization in the piglet: operationalizing the concept of an essential circulation. Pediatr Res 1994;35: 649-56.
10. G-nitro-L-arginine and L-arginine on regional cerebral blood flow in the cat. J Physiol (Lond) 1992;449:183-96.
11. Morikawa E, Rosenblatt S, Moskowitz MA. L-Arginine dilates rat pial arterioles by nitric oxide-dependent mechanisms and increases blood flow during focal cerebral ischaemia. Br J Pharmacol 1992;107:905-7.
12. G-mono-methyl-L-arginine reversibly decreases cerebral blood flow in piglets. Crit Care Med 1994;22:384-92.
13. Heymann MA, Payne BD, Hoffman JIE, Rudolph AM. Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Dis 1977;20:55-79.
14. Wang Q, Kjaer T, Jorgensen MB, et al. Nitric oxide does not act as a mediator coupling cerebral blood flow to neural activity following somatosensory stimuli in rats. Neurol Res 1993;15:33-6.
15. Iadecola C, Xu X. Nitro-L-arginine attenuates hypercapnic cerebrovasodilation without affecting cerebral metabolism. Am J Physiol 1994;266(Pt 2):R518-25.
16. Iadecola C, Zhang F. Nitric oxide-dependent and -independent components of cerebrovasodilation elicited by hypercapnia. Am J Physiol 1994;266(2 Pt 2):R546-52.
17. Zhang F, Iadecola C. Nitroprusside improves blood flow and reduces brain damage after focal ischaemia. NeuroReport 1993;4:559-62.
18. Bredt DS, Hwang PM, Snyder SH. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 1990;347:714-8.
19. Katusic ZS, Vanhoutte PM. Anoxic contractions in isolated canine cerebral arteries: contribution of endothelium-derived factors, metabolites of arachidonic acid, and calcium entry. J Cardiovasc Pharmacol 1986;8(Suppl 8):S97-101.
20. Klaas M, Wadsworth R. Contraction followed by relaxation in response to hypoxia in the sheep isolated middle cerebral artery. Eur J Pharmacol 1989;168:187-92.
21. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985;312:159-63.
22. Marshall JJ, Kontos HA. Endothelium-derived relaxing factors. A perspective from in vivo data. Hypertension 1990;16: 371-86.