Different obscurin isoforms localize to distinct sites at sarcomeres

FEBS Letters

Volumn 581, Issue 8, 2007, Pages 1549-1554

  Bowman, Amber L ^a   Kontrogianni Konstantopoulos, Aikaterini ^a   Hirsch, Sara S ^a   Geisler, Sarah B ^b   Gonzalez Serratos, Hugo ^a   Russell, Mark W ^b   Bloch, Robert J ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

I band; M line; Obscurin; Stretch; Z disk

Indexed keywords

OBSCURIN A; OBSCURIN B; PHOSPHOTRANSFERASE; PROTEIN; RHO FACTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; MUSCLE LENGTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SARCOMERE; SKELETAL MUSCLE;

ANIMALS; MUSCLE PROTEINS; MUSCLE, SKELETAL; PROTEIN ISOFORMS; SARCOMERES;

EID: 34047110229     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.03.011     Document Type: Article

References (22)

1. Young P., Ehler E., and Gautel M. Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly. J. Cell Biol. 154 (2001) 123-136
2. Russell M.W., Raeker M.O., Korytkowski K.A., and Sonneman K.J. Identification, tissue expression and chromosomal localization of human Obscurin-MLCK, a member of the titin and Dbl families of myosin light chain kinases. Gene 282 (2002) 237-246
3. Bang M.L., Centner T., Fornoff F., Geach A.J., Gotthardt M., McNabb M., Witt C.C., Labeit D., Gregorio C.C., Granzier H., and Labeit S. The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system. Circ. Res. 89 (2001) 1065-1072
4. Fukuzawa A., Idowu S., and Gautel M. Complete human gene structure of obscurin: implications for isoform generation by differential splicing. J. Muscle Res. Cell Motil. 26 (2006) 427-434
5. Kontrogianni-Konstantopoulos A., and Bloch R.J. Obscurin: a multitasking muscle giant. J. Muscle Res. Cell Motil. 26 (2006) 419-426
6. Sutter S.B., Raeker M.O., Borisov A.B., and Russell M.W. Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases. Dev. Genes Evol. 214 (2004) 352-359
7. Bagnato P., Barone V., Giacomello E., Rossi D., and Sorrentino V. Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles. J. Cell Biol. 160 (2003) 245-253
8. Borisov A.B., Kontrogianni-Konstantopoulos A., Bloch R.J., Westfall M.V., and Russell M.W. Dynamics of obscurin localization during differentiation and remodeling of cardiac myocytes: obscurin as an integrator of myofibrillar structure. J. Histochem. Cytochem. 52 (2004) 1117-1127
9. Kontrogianni-Konstantopoulos A., Jones E.M., Van Rossum D.B., and Bloch R.J. Obscurin is a ligand for small ankyrin 1 in skeletal muscle. Mol. Biol. Cell 14 (2003) 1138-1148
10. Borisov A.B., Raeker M.O., Kontrogianni-Konstantopoulos A., Yang K., Kurnit D.M., Bloch R.J., and Russell M.W. Rapid response of cardiac obscurin gene cluster to aortic stenosis: differential activation of Rho-GEF and MLCK and involvement in hypertrophic growth. Biochem. Biophys. Res. Commun. 310 (2003) 910-918
11. Kontrogianni-Konstantopoulos A., Catino D.H., Strong J.C., and Bloch R.J. De novo myofibrillogenesis in C2C12 cells: evidence for the independent assembly of M bands and Z disks. Am. J. Physiol. Cell Physiol. 290 (2006) C626-C637
12. Kontrogianni-Konstantopoulos A., Catino D.H., Strong J.C., Sutter S., Borisov A.B., Pumplin D.W., Russell M.W., and Bloch R.J. Obscurin modulates the assembly and organization of sarcomeres and the sarcoplasmic reticulum. FASEB J. 20 (2006) 2102-2111
13. Small T.M., Gernert K.M., Flaherty D.B., Mercer K.B., Borodovsky M., and Benian G.M. Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains. J. Mol. Biol. 342 (2004) 91-108
14. Frangioni J.V., and Neel B.G. Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins. Anal. Biochem. 210 (1993) 179-187
15. Mercado-Pimentel M.E., Jordan N.C., and Aisemberg G.O. Affinity purification of GST fusion proteins for immunohistochemical studies of gene expression. Protein Exp. Purif. 26 (2002) 260-265
16. Raeker M.O., Su F., Geisler S.B., Borisov A.B., Kontrogianni-Konstantopoulos A., Lyons S.E., and Russell M.W. Obscurin is required for the lateral alignment of striated myofibrils in zebrafish. Dev. Dyn. 235 (2006) 2018-2029
17. Kontrogianni-Konstantopoulos A., Catino D.H., Strong J.C., Randall W.R., and Bloch R.J. Obscurin regulates the organization of myosin into A bands. Am. J. Physiol. Cell Physiol. 287 (2004) C209-C217
18. Brown L.M., Gonzalez-Serratos H., and Huxley A.F. Sarcomere and filament lengths in passive muscle fibres with wavy myofibrils. J. Muscle Res. Cell Motil. 5 (1984) 293-314
19. Brown L.M., Gonzalez-Serratos H., and Huxley A.F. Structural studies of the waves in striated muscle fibres shortened passively below their slack length. J. Muscle Res. Cell Motil. 5 (1984) 273-292
20. Borisov A.B., Sutter S.B., Kontrogianni-Konstantopoulos A., Bloch R.J., Westfall M.V., and Russell M.W. Essential role of obscurin in cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing. Histochem. Cell Biol. 125 (2006) 227-238
21. Linke W.A., Ivemeyer M., Olivieri N., Kolmerer B., Ruegg J.C., and Labeit S. Towards a molecular understanding of the elasticity of titin. J. Mol. Biol. 261 (1996) 62-71
22. Faulkner G., Lanfranchi G., and Valle G. Telethonin and other new proteins of the Z-disc of skeletal muscle. IUBMB Life 51 (2001) 275-282