Obscurin: A multitasking muscle giant

Journal of Muscle Research and Cell Motility

Volumn 26, Issue 6-8, 2005, Pages 419-426

  Kontrogianni Konstantopoulos, Aikaterini ^a   Bloch, Robert J ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; ANKYRIN I; CONNECTIN; GIANT PROTEIN; MEMBRANE PROTEIN; MUSCLE PROTEIN; MYOSIN; NEBULIN; OBSCURIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; GENE OVEREXPRESSION; MUSCLE CONTRACTILITY; MUSCLE DEVELOPMENT; MUSCLE FIBRIL; MYOFILAMENT; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; SARCOMERE; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; VERTEBRATE;

ANIMALS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MICROSCOPY, IMMUNOELECTRON; MUSCLE FIBERS; MUSCLE FIBERS, SKELETAL; MUSCLE PROTEINS; MUSCLE, SKELETAL; MYOFIBRILS; RATS; SARCOMERES; SARCOPLASMIC RETICULUM;

VERTEBRATA;

EID: 33745698388     PISSN: 01424319     EISSN: 15732657     Source Type: Journal    
DOI: 10.1007/s10974-005-9024-7     Document Type: Conference Paper

References (27)

1. Bagnato P, Barone V, Giacomello E, Rossi D and Sorrentino V (2003) Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles. J Cell Biol 160: 245-253.
2. Bang ML, Centner T, Fornoff F, Geach AJ, Gotthardt M, McNabb M, Witt CC, Labeit D, Gregorio CC, Granzier H and Labeit D (2001) The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system. Circ Res 89: 1065-1072.
3. Benian GM, Tinley TL, Tang X and Borodovsky M (1996) The Caenorhabditis elegans gene unc-89, required for muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains. J Cell Biol 132: 835-848.
4. Borisov AB, Raeker MO, Kontrogianni-Konstantopoulos A, Yang K, Kurnit DM, Bloch RJ and Russell MW (2003) Rapid response of cardiac obscurin gene cluster to aortic stenosis: differential activation of Rho-GEF and MLCK and involvement in hypertrophic growth. Biochem Biophys Res Commun 310: 910-918.
5. Brockington M, Sewry CA, Herrmann R, Naom I, Dearlove A, Rhodes M, Topaloglu H, Dubowitz V, Voit T and Muntoni F (2000) Assignment of a form of congenital muscular dystrophy with secondary merosin deficiency to chromosome 1q42. Am J Hum Genet 66: 428-435.
6. Clark KA, McElhinny AS, Beckerle MS and Gregorio CC (2002) Striated muscle cytoarchitecture: an intricate web of form and function. Annu Rev Cell Dev Biol 18: 637-706.
7. Flashman E, Redwood C, Moolman-Smook J and Watkins H (2004) Cardiac myosin binding protein C: its role in physiology and disease. Circ Res 94: 1279-1289.
8. Gautel M, Mues A and Young P (1999) Control of sarcomeric assembly: the flow of information on titin. Rev Physiol Biochem Pharmacol 138: 97-137.
9. Kontrogianni-Konstantopoulos A, Catino DH, Strong JC, Randall WR and Bloch RJ (2004) Obscurin regulates the organization of myosin into A bands. Am J Physiol Cell Physiol 287: C209-C217.
10. Kontrogianni-Konstantopoulos A, Catino DH, Strong JC and Bloch RJ (2006) De novo myofibrillogenesis in C2C12 cells: evidence for the independent assembly of M-lines and Z-disks. Am J Physiol Cell Physiol 290: C626-C637.
11. Kontrogianni-Konstantopoulos A, Jones EM, Van Rossum DB and Bloch RJ (2003) Obscurin is a ligand for small ankyrin 1 in skeletal muscle. Mol Biol Cell 14: 1138-1148.
12. Kruger M, Wright J and Wang K (1991) Nebulin as a length regulator of thin filaments of vertebrate skeletal muscles: correlation of thin filament length, nebulin size, and epitope profile. J Cell Biol 115: 97-107.
13. Labeit S, Kolmerer B and Linke WA (1997) The giant protein titin. Emerging roles in physiology and pathophysiology. Circ Res 80: 290-294.
14. Makarenko I, Opitz CA, Leake MC, Neagoe C, Kulke M, Gwathmey JK, Del Monte F, Hajjar RJ, and Linke WA (2004) Passive stiffness changes due to upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts. Circ Res 95: 708-716.
15. McElhinny AS, Kazmierski ST, Labeit S and Gregorio CC (2003) Nebulin: the nebulous, multifunctional giant of striated muscle. Trends Cardiovasc Med 13: 195-201.
16. Porter NC, Resneck WG, O'Neill A, Van Rossum DB, Stone MR and Bloch RJ (2005) Association of small ankyrin 1 with the sarcoplasmic reticulum. Memb Mol Biol 22: 421-432.
17. Russell MW, Raeker MO, Korytkowski KA and Sonneman KJ (2002) Identification, tissue expression and chromosomal localization of human Obscurin-MLCK, a member of the titin and Dbl families of myosin light chain kinases. Gene 282: 237-246.
18. Sanger JW, Chowrashi P, Shaner NC, Spalthoff S, Wang J, Freeman NL and Sanger JM (2002) Myofibrillogenesis in skeletal muscle cells. Clin Orthop Related Res 403S: S153-S162.
19. Small TM, Gernert KM, Flaherty DB, Mercer KB, Borodovsky M and Benian GM (2004) Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains. J Mol Biol 342: 91-108.
20. Trombitas K, Greaser M, Labeit S, Jin JP, Kellermayer M, Helmes M and Granzier H (1998) Titin extensibility in situ: entropic elasticity of permanently folded and permanently unfolded molecular segments. J Cell Biol 140: 853-859.
21. Trombitas K, Jin JP and Granzier H (1995) The mechanically active domain of titin in cardiac muscle. Circ Res 77: 856-861.
22. Wang (1996) Titin/connectin and nebulin: giant protein rulers of muscle structure and function. Adv Biophys 33: 123-134.
23. Winegrad S (1999) Cardiac myosin binding protein C. Circ Res 84: 1117-1126.
24. Winegrad S (2000) Myosin binding protein C, a potential regulator of cardiac contractility. Circ Res 86: 6-7.
25. Wu Y, Bell SP, Trombitas K, Witt CC, Labeit S, LeWinter MM and Granzier H (2002) Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness. Circulation 106: 1384-1389.
26. Young P, Ehler E and Gautel M (2001) Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly. J Cell Biol 154: 123-136.
27. Zhou D, Birkenmeier CS, Williams MW, Sharp JJ, Barker JE and Bloch RJ (1997) Small, membrane-bound alternatively spliced forms of ankyrin-1 associated with the sarcoplasmic reticulum of mammalian skeletal muscle. J Cell Biol 136: 621-631.