Nucleus accumbens serotonin transporters in alcoholics measured by whole-hemisphere autoradiography

Alcohol

Volumn 40, Issue 3, 2006, Pages 177-184

  Storvik, Markus ^a   Tiihonen, Jari ^a   Haukijärvi, Tuija ^a   Tupala, Erkki ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Alcohol induced disorders; Autoradiography; Ethanol induced nervous system disorders; Human brain; Serotonin; Transporters

Indexed keywords

ALCOHOL; CITALOPRAM; SEROTONIN TRANSPORTER;

ADULT; AGED; ALCOHOLISM; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; CADAVER; CINGULATE GYRUS; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HEMISPHERE; HUMAN; HUMAN TISSUE; MALE; NUCLEUS ACCUMBENS; STATISTICAL SIGNIFICANCE;

ADULT; AGED; ALCOHOLISM; AUTORADIOGRAPHY; BINDING SITES; CASE-CONTROL STUDIES; CITALOPRAM; FEMALE; FINLAND; HUMANS; MALE; MIDDLE AGED; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; TRITIUM;

EID: 34047105847     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.alcohol.2006.12.005     Document Type: Article

References (35)

1. Altman D.G. Practical Statistics for Medical Research (1999), CRC Press LLC, Boca Raton, FL 455-460
2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. (1994), American Psychiatric Press, Washington, DC
3. 3H]citalopram as markers of the human brain 5-HT uptake site, a nonalcoholic comparison study. J Neural Transm Gen Sect 97 (1994) 27-40
4. Brown P., and Molliver M.E. Dual serotonin (5-HT) projections to the nucleus accumbens core and shell, relation of the 5-HT transporter to amphetamine-induced neurotoxicity. J Neurosci 20 (2000) 1952-1963
5. Budygin E.A., Brodie M.S., Sotnikova T.D., Mateo Y., John C.E., Cyr M., Gainetdinov R.R., and Jones S.R. Dissociation of rewarding and dopamine transporter-mediated properties of amphetamine. Proc Natl Acad Sci USA 101 (2004) 7781-7786
6. Cardinal R.N., Parkinson J.A., Hall J., and Everitt B.J. The contribution of the amygdala, nucleus accumbens, and prefrontal cortex to emotion and motivated behaviour. Int Congr Ser 1250 (2003) 347-370
7. Clarke H.F., Dalley J.W., Crofts H.S., Robbins T.W., and Roberts A.C. Cognitive inflexibility after prefrontal serotonin depletion. Science 304 (2004) 878-880
8. Clarke H.F., Walker S.C., Crofts H.S., Dalley J.W., Robbins T.W., and Roberts A.C. Prefrontal serotonin depletion affects reversal learning but not attentional set shifting. J Neurosci 25 (2005) 532-538
9. Cloninger C.R., Sigvardsson S., Gilligan S.B., von Knorring A.L., Reich T., and Bohman M. Genetic heterogeneity and the classification of alcoholism. Adv Alcohol Subst Abuse 7 (1988) 3-16
10. Cloninger C.R. The psychobiological regulation of social cooperation. Nat Med 1 (1995) 623-625
11. Cohen J. Statistical Power Analysis for the Behavioural Sciences. 2nd ed. (1988), Lawrence Erlbaum Associates Publishers, Hillsdale, NJ 40
12. de Deurwaerdere P., and Spampinato U. Role of serotonin(2A) and serotonin(2B/2C) receptor subtypes in the control of accumbal and striatal dopamine release elicited in vivo by dorsal raphe nucleus electrical stimulation. J Neurochem 73 (1999) 1033-1042
13. de Deurwaerdere P., Stinus L., and Spampinato U. Opposite change of in vivo dopamine release in the rat nucleus accumbens and striatum that follows electrical stimulation of dorsal raphe nucleus, role of 5-HT3 receptors. J Neurosci 18 (1998) 6528-6538
14. Franken I.H.A. Drug craving and addiction, integrating psychological and neuropsychopharmacological approaches. Prog Neuro-Psychopharmacol Biol Psychiatry 27 (2003) 563-579
15. Gorwood P., Batel P., Ades J., Hamon M., and Boni C. Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior. Biol Psychiatry 48 4 (2000) 259-264
16. Heinz A., Jones D.W., Gorey J.G., Bennet A., Suomi S.J., Weinberger D.R., and Higley J.D. Serotonin transporter availability correlates with alcohol intake in non-human primates. Mol Psychiatry 8 (2003) 231-234
17. Heinz A., Ragan P., Jones D.W., Hommer D., Williams W., Knable M.B., Gorey J.G., Doty L., Geyer C., Lee K.S., Coppola R., Weinberger D.R., and Linnoila M. Reduced central serotonin transporters in alcoholism. Am J Psychiatry 155 (1998) 1544-1549
18. Hesse S., Barthel H., Murai T., Muller U., Muller D., Seese A., Kluge R., and Sabri O. Is correction for age necessary in neuroimaging studies of the central serotonin transporter?. Eur J Nucl Med Mol Imaging 30 (2003) 427-430
19. Kakiuchi T., Tsukada H., Fukumoto D., and Nishitama S. Effects of aging on serotonin transporter availability and its response to fluvoxamine in the living brain, PET study with [(11)C](+)McN5652 and [(11)C](-)McN5652 in conscious monkeys. Synapse 40 (2001) 170-179
20. Koob G.F., and Le Moal M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24 (2001) 97-129
21. Mantere T., Tupala E., Hall H., Särkioja T., Räsänen P., Bergström K., Callaway J., and Tiihonen J. Serotonin transporter distribution and density in the cerebral cortex of alcoholic and nonalcoholic comparison subjects, a whole-hemisphere autoradiography study. Am J Psychiatry 159 (2002) 599-606
22. Mash D.C., Staley J.K., Izenwasser S., Basile M., and Ruttenber A.J. Serotonin transporters upregulate with chronic cocaine use. J Chem Neuroanat 20 (2000) 271-280
23. Repo-Tiihonen E., Virkkunen M., and Tiihonen J. Mortality of antisocial male criminals. J Forensic Psychiatry 12 3 (2001) 677-683
24. Ryding E., Lindstrom M., Bradvik B., Grabowski M., Bosson P., Traskman-Bendz L., and Rosen I. A new model for separation between brain dopamine and serotonin transporters in 123I-beta-CIT SPECT measurements, normal values and sex and age dependence. Eur J Nucl Med Mol Imaging 31 (2004) 1114-1118
25. Self D.W., and Nestler E.J. Molecular mechanisms of drug reinforcement and addiction. Annu Rev Neurosci 18 (1995) 463-495
26. Strother W.N., Lumeng L., Li T.K., and McBride W.J. Dopamine and serotonin content in select brain regions of weanling and adult alcohol drinking rat lines. Pharmacol Biochem Behav 80 (2005) 229-237
27. Tiihonen J., Kuikka J., Bergström K., Hakola P., Karhu J., Ryynänen O.-P., and Föhr J. Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics. Nat Med 7 (1995) 654-657
28. Träskman-Bendz L. Whole brain serotonin- and dopamine transporters in suicide attempters and controls. Iceland Med J 48 (2003) 22
29. Tupala E., Hall H., Bergstrom K., Mantere T., Räsänen P., Särkioja T., Hiltunen J., and Tiihonen J. Different effect of age on dopamine transporters in the dorsal and ventral striatum of controls and alcoholics. Synapse 48 (2003) 205-211
30. Tupala E., Hall H., Bergstrom K., Sarkioja T., Rasanen P., Mantere T., Callaway J., Hiltunen J., and Tiihonen J. Dopamine D(2)/D(3)-receptor and transporter densities in nucleus accumbens and amygdala of type 1 and 2 alcoholics. Mol Psychiatry 6 3 (2001) 261-267
31. Tupala E., Hall H., Halonen P., and Tiihonen J. Cortical dopamine D2 receptors in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography. Synapse 54 (2004) 129-137
32. Tupala E., Hall H., Mantere T., Räsänen P., Särkioja T., and Tiihonen J. Dopamine receptors and transporters in the brain reward circuits of type 1 and 2 alcoholics measured with human whole hemisphere autoradiography. Neuroimage 19 (2003) 145-155
33. Tupala T., Hall H., Särkioja T., Räsänen P., and Tiihonen J. Dopamine-transporter density in nucleus accumbens of type-1 alcoholics. Lancet 355 (2000) 380
34. Tupala E., Kuikka J.T., Hall H., Bergström K., Särkioja T., Räsänen P., Mantere T., Hiltunen J., Vepsäläinen J., and Tiihonen J. Measurement of the striatal dopamine transporter density and heterogeneity in type 1 alcoholics using human whole hemisphere autoradiography. Neuroimage 14 (2001) 87-94
35. Zar J. Biostatistical Analysis. 2nd ed. (1984), Prentice-Hall Inc, Englewood Cliffs, NJ pp. 310-317