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Volumn 21, Issue 4, 2007, Pages 395-408

Inducing a mode of NK-resistance to suppression by stress and surgery: A potential approach based on low dose of poly I-C to reduce postoperative cancer metastasis

Author keywords

Immunity; Metastasis; Natural killer; Poly I C; Stress; Surgery

Indexed keywords

POLYINOSINIC POLYCYTIDYLIC ACID;

EID: 34047095585     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2006.12.002     Document Type: Article
Times cited : (26)

References (59)
  • 1
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou L., Holt A.C., Medzhitov R., and Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413 6857 (2001) 732-738
    • (2001) Nature , vol.413 , Issue.6857 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 3
    • 33746874801 scopus 로고    scopus 로고
    • Autologous control of a highly malignant syngeneic CRNK-16 leukemia in the rat: a role for NK cells
    • Avraham R., Inbar S., Rosenne E., and Ben-Eliyahu S. Autologous control of a highly malignant syngeneic CRNK-16 leukemia in the rat: a role for NK cells. Cancer Immunol. Immunother. 55 11 (2006) 1348-1357
    • (2006) Cancer Immunol. Immunother. , vol.55 , Issue.11 , pp. 1348-1357
    • Avraham, R.1    Inbar, S.2    Rosenne, E.3    Ben-Eliyahu, S.4
  • 4
    • 34047251646 scopus 로고    scopus 로고
    • Avraham, R., Schwartz, Y., Rosenne, E., Melamed, R.,Ben-Eliyahu, S. (2004). IL-12-based immunotherapy reduces post-surgery immunosuppression and metastasis, and increases survival from experimental leukemia. Paper presented at the Psychoneuroimmunology Research Society, Titisee, Germany.
  • 5
    • 0020526354 scopus 로고
    • In vivo role of natural killer cells: involvement of large granular lymphocytes in the clearance of tumor cells in anti-asialo GM1-treated rats
    • Barlozzari T., Reynolds C.W., and Herberman R.B. In vivo role of natural killer cells: involvement of large granular lymphocytes in the clearance of tumor cells in anti-asialo GM1-treated rats. J. Immunol. 131 2 (1983) 1024-1027
    • (1983) J. Immunol. , vol.131 , Issue.2 , pp. 1024-1027
    • Barlozzari, T.1    Reynolds, C.W.2    Herberman, R.B.3
  • 7
    • 0000404702 scopus 로고
    • In vivo assessment of natural killer cell activity in rats
    • Ben-Eliyahu S., and Page G.G. In vivo assessment of natural killer cell activity in rats. Prog. Neuroendocrinemmunol. 5 (1992) 199-214
    • (1992) Prog. Neuroendocrinemmunol. , vol.5 , pp. 199-214
    • Ben-Eliyahu, S.1    Page, G.G.2
  • 8
    • 0033559181 scopus 로고    scopus 로고
    • Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity
    • Ben-Eliyahu S., Page G.G., Yirmiya R., and Shakhar G. Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity. Int. J. Cancer 80 6 (1999) 880-888
    • (1999) Int. J. Cancer , vol.80 , Issue.6 , pp. 880-888
    • Ben-Eliyahu, S.1    Page, G.G.2    Yirmiya, R.3    Shakhar, G.4
  • 9
    • 0034532188 scopus 로고    scopus 로고
    • Suppression of NK cell activity and of resistance to metastasis by stress: a role for adrenal catecholamines and beta-adrenoceptors
    • Ben-Eliyahu S., Shakhar G., Page G.G., Stefanski V., and Shakhar K. Suppression of NK cell activity and of resistance to metastasis by stress: a role for adrenal catecholamines and beta-adrenoceptors. Neuroimmunomodulation 8 3 (2000) 154-164
    • (2000) Neuroimmunomodulation , vol.8 , Issue.3 , pp. 154-164
    • Ben-Eliyahu, S.1    Shakhar, G.2    Page, G.G.3    Stefanski, V.4    Shakhar, K.5
  • 10
    • 0032863471 scopus 로고    scopus 로고
    • Hypothermia in barbiturate-anesthetized rats suppresses natural killer cell activity and compromises resistance to tumor metastasis: a role for adrenergic mechanisms
    • Ben-Eliyahu S., Shakhar G., Rosenne E., Levinson Y., and Beilin B. Hypothermia in barbiturate-anesthetized rats suppresses natural killer cell activity and compromises resistance to tumor metastasis: a role for adrenergic mechanisms. Anesthesiology 91 3 (1999) 732-740
    • (1999) Anesthesiology , vol.91 , Issue.3 , pp. 732-740
    • Ben-Eliyahu, S.1    Shakhar, G.2    Rosenne, E.3    Levinson, Y.4    Beilin, B.5
  • 11
    • 0025744988 scopus 로고
    • Stress increases metastatic spread of a mammary tumor in rats: evidence for mediation by the immune system
    • Ben-Eliyahu S., Yirmiya R., Liebeskind J.C., Taylor A.N., and Gale R.P. Stress increases metastatic spread of a mammary tumor in rats: evidence for mediation by the immune system. Brain. Behav. Immun. 5 2 (1991) 193-205
    • (1991) Brain. Behav. Immun. , vol.5 , Issue.2 , pp. 193-205
    • Ben-Eliyahu, S.1    Yirmiya, R.2    Liebeskind, J.C.3    Taylor, A.N.4    Gale, R.P.5
  • 12
    • 0021194533 scopus 로고
    • Interferon inhibits agonist-induced cyclic AMP accumulation in human lymphocytes
    • Davis V.L., Earp H.S., and Stempel D.A. Interferon inhibits agonist-induced cyclic AMP accumulation in human lymphocytes. Am. Rev. Respir. Dis. 130 2 (1984) 167-170
    • (1984) Am. Rev. Respir. Dis. , vol.130 , Issue.2 , pp. 167-170
    • Davis, V.L.1    Earp, H.S.2    Stempel, D.A.3
  • 13
    • 0035103406 scopus 로고    scopus 로고
    • Effects of in vitro treatment with fluticasone propionate on natural killer and lymphokine-induced killer activity in asthmatic and healthy individuals
    • Di Lorenzo G., Esposito Pellitteri M., Drago A., Di Blasi P., Candore G., Balistreri C., Listi F., and Caruso C. Effects of in vitro treatment with fluticasone propionate on natural killer and lymphokine-induced killer activity in asthmatic and healthy individuals. Allergy 56 4 (2001) 323-327
    • (2001) Allergy , vol.56 , Issue.4 , pp. 323-327
    • Di Lorenzo, G.1    Esposito Pellitteri, M.2    Drago, A.3    Di Blasi, P.4    Candore, G.5    Balistreri, C.6    Listi, F.7    Caruso, C.8
  • 14
    • 2442575839 scopus 로고    scopus 로고
    • Catecholaminergic control of NK cell cytolytic activity regulatory factors in the spleen
    • Dokur M., Boyadjieva N., and Sarkar D.K. Catecholaminergic control of NK cell cytolytic activity regulatory factors in the spleen. J. Neuroimmunol. 151 1-2 (2004) 148-157
    • (2004) J. Neuroimmunol. , vol.151 , Issue.1-2 , pp. 148-157
    • Dokur, M.1    Boyadjieva, N.2    Sarkar, D.K.3
  • 15
    • 0028304710 scopus 로고
    • Polyinosinic: polycytidylic acid is a potent activator of endothelial cells
    • Doukas J., Cutler A.H., and Mordes J.P. Polyinosinic: polycytidylic acid is a potent activator of endothelial cells. Am. J. Pathol. 145 1 (1994) 137-147
    • (1994) Am. J. Pathol. , vol.145 , Issue.1 , pp. 137-147
    • Doukas, J.1    Cutler, A.H.2    Mordes, J.P.3
  • 16
    • 8344239652 scopus 로고    scopus 로고
    • A review of recent findings involving interleukin-2-based cancer therapy
    • Eklund J.W., and Kuzel T.M. A review of recent findings involving interleukin-2-based cancer therapy. Curr. Opin. Oncol. 16 6 (2004) 542-546
    • (2004) Curr. Opin. Oncol. , vol.16 , Issue.6 , pp. 542-546
    • Eklund, J.W.1    Kuzel, T.M.2
  • 17
    • 0025232854 scopus 로고
    • The effects of 16,16-dimethyl PGE2 and phosphodiesterase inhibitors on Con A blastogenic responses and NK cytotoxic activity of mouse spleen cells
    • Ellis N.K., Duffie G.P., Young M.R., and Wepsic H.T. The effects of 16,16-dimethyl PGE2 and phosphodiesterase inhibitors on Con A blastogenic responses and NK cytotoxic activity of mouse spleen cells. J. Leukoc. Biol. 47 4 (1990) 371-377
    • (1990) J. Leukoc. Biol. , vol.47 , Issue.4 , pp. 371-377
    • Ellis, N.K.1    Duffie, G.P.2    Young, M.R.3    Wepsic, H.T.4
  • 18
    • 14044267522 scopus 로고    scopus 로고
    • Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus
    • Guillot L., Le Goffic R., Bloch S., Escriou N., Akira S., Chignard M., and Si-Tahar M. Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J. Biol. Chem. 280 7 (2005) 5571-5580
    • (2005) J. Biol. Chem. , vol.280 , Issue.7 , pp. 5571-5580
    • Guillot, L.1    Le Goffic, R.2    Bloch, S.3    Escriou, N.4    Akira, S.5    Chignard, M.6    Si-Tahar, M.7
  • 19
    • 0023505325 scopus 로고
    • Toxicity of polyinosinic-polycytidylic acid admixed with poly-l-lysine and solubilized with carboxymethylcellulose in mice
    • Hartmann D., Schneider M.A., Lenz B.F., and Talmadge J.E. Toxicity of polyinosinic-polycytidylic acid admixed with poly-l-lysine and solubilized with carboxymethylcellulose in mice. Pathol. Immunopathol. Res. 6 1 (1987) 37-50
    • (1987) Pathol. Immunopathol. Res. , vol.6 , Issue.1 , pp. 37-50
    • Hartmann, D.1    Schneider, M.A.2    Lenz, B.F.3    Talmadge, J.E.4
  • 21
    • 0030801212 scopus 로고    scopus 로고
    • IL-1 beta alters beta-adrenergic receptor adenylyl cyclase system function in human airway epithelial cells
    • Kelsen S.G., Anakwe O., Aksoy M.O., Reddy P.J., and Dhanasekaran N. IL-1 beta alters beta-adrenergic receptor adenylyl cyclase system function in human airway epithelial cells. Am. J. Physiol. 273 3 Pt 1 (1997) L694-L700
    • (1997) Am. J. Physiol. , vol.273 , Issue.3 PART 1
    • Kelsen, S.G.1    Anakwe, O.2    Aksoy, M.O.3    Reddy, P.J.4    Dhanasekaran, N.5
  • 24
    • 0029861298 scopus 로고    scopus 로고
    • Mechanisms of impaired beta-adrenoceptor-induced airway relaxation by interleukin-1beta in vivo in the rat
    • Koto H., Mak J.C., Haddad E.B., Xu W.B., Salmon M., Barnes P.J., and Chung K.F. Mechanisms of impaired beta-adrenoceptor-induced airway relaxation by interleukin-1beta in vivo in the rat. J. Clin. Invest. 98 8 (1996) 1780-1787
    • (1996) J. Clin. Invest. , vol.98 , Issue.8 , pp. 1780-1787
    • Koto, H.1    Mak, J.C.2    Haddad, E.B.3    Xu, W.B.4    Salmon, M.5    Barnes, P.J.6    Chung, K.F.7
  • 26
    • 0019988560 scopus 로고
    • Regulation of human natural killing. II. Protective effect of interferon on NK cells from suppression by PGE2
    • Leung K.H., and Koren H.S. Regulation of human natural killing. II. Protective effect of interferon on NK cells from suppression by PGE2. J. Immunol. 129 4 (1982) 1742-1747
    • (1982) J. Immunol. , vol.129 , Issue.4 , pp. 1742-1747
    • Leung, K.H.1    Koren, H.S.2
  • 27
    • 0021328683 scopus 로고
    • Regulation of human natural killing. III. Mechanism for interferon induction of loss of susceptibility to suppression by cyclic AMP elevating agents
    • Leung K.H., and Koren H.S. Regulation of human natural killing. III. Mechanism for interferon induction of loss of susceptibility to suppression by cyclic AMP elevating agents. J. Immunol. 132 3 (1984) 1445-1450
    • (1984) J. Immunol. , vol.132 , Issue.3 , pp. 1445-1450
    • Leung, K.H.1    Koren, H.S.2
  • 28
    • 0018245695 scopus 로고
    • Phase I-II trials of poly IC stabilized with poly-l-lysine
    • Levine A.S., and Levy H.B. Phase I-II trials of poly IC stabilized with poly-l-lysine. Cancer Treat. Rep. 62 11 (1978) 1907-1912
    • (1978) Cancer Treat. Rep. , vol.62 , Issue.11 , pp. 1907-1912
    • Levine, A.S.1    Levy, H.B.2
  • 29
    • 0033563118 scopus 로고    scopus 로고
    • A novel animal model for hemangiomas: inhibition of hemangioma development by the angiogenesis inhibitor TNP-470
    • Liekens S., Verbeken E., Vandeputte M., De Clercq E., and Neyts J. A novel animal model for hemangiomas: inhibition of hemangioma development by the angiogenesis inhibitor TNP-470. Cancer Res. 59 10 (1999) 2376-2383
    • (1999) Cancer Res. , vol.59 , Issue.10 , pp. 2376-2383
    • Liekens, S.1    Verbeken, E.2    Vandeputte, M.3    De Clercq, E.4    Neyts, J.5
  • 32
    • 0027389065 scopus 로고
    • Regulation of natural killer cell activity by transforming growth factor-beta and prostaglandin E2
    • Malygin A.M., Meri S., and Timonen T. Regulation of natural killer cell activity by transforming growth factor-beta and prostaglandin E2. Scand. J. Immunol. 37 1 (1993) 71-76
    • (1993) Scand. J. Immunol. , vol.37 , Issue.1 , pp. 71-76
    • Malygin, A.M.1    Meri, S.2    Timonen, T.3
  • 33
    • 0029089972 scopus 로고
    • Polyinosinic acid: polycytidylic acid promotes T helper type 1-specific immune responses by stimulating macrophage production of interferon-alpha and interleukin-12
    • Manetti R., Annunziato F., Tomasevic L., Gianno V., Parronchi P., Romagnani S., and Maggi E. Polyinosinic acid: polycytidylic acid promotes T helper type 1-specific immune responses by stimulating macrophage production of interferon-alpha and interleukin-12. Eur. J. Immunol. 25 9 (1995) 2656-2660
    • (1995) Eur. J. Immunol. , vol.25 , Issue.9 , pp. 2656-2660
    • Manetti, R.1    Annunziato, F.2    Tomasevic, L.3    Gianno, V.4    Parronchi, P.5    Romagnani, S.6    Maggi, E.7
  • 34
    • 1642422416 scopus 로고    scopus 로고
    • Toll-like receptor 3: a link between toll-like receptor, interferon and viruses
    • Matsumoto M., Funami K., Oshiumi H., and Seya T. Toll-like receptor 3: a link between toll-like receptor, interferon and viruses. Microbiol. Immunol. 48 3 (2004) 147-154
    • (2004) Microbiol. Immunol. , vol.48 , Issue.3 , pp. 147-154
    • Matsumoto, M.1    Funami, K.2    Oshiumi, H.3    Seya, T.4
  • 35
    • 12344326829 scopus 로고    scopus 로고
    • Marginating pulmonary-NK activity and resistance to experimental tumor metastasis: suppression by surgery and the prophylactic use of a beta-adrenergic antagonist and a prostaglandin synthesis inhibitor
    • Melamed R., Rosenne E., Shakhar K., Schwartz Y., Abudarham N., and Ben-Eliyahu S. Marginating pulmonary-NK activity and resistance to experimental tumor metastasis: suppression by surgery and the prophylactic use of a beta-adrenergic antagonist and a prostaglandin synthesis inhibitor. Brain. Behav. Immun. 19 2 (2005) 114-126
    • (2005) Brain. Behav. Immun. , vol.19 , Issue.2 , pp. 114-126
    • Melamed, R.1    Rosenne, E.2    Shakhar, K.3    Schwartz, Y.4    Abudarham, N.5    Ben-Eliyahu, S.6
  • 36
    • 0037097549 scopus 로고    scopus 로고
    • Protein kinase R regulates double-stranded RNA induction of TNF-alpha but not IL-1 beta mRNA in human epithelial cells
    • Meusel T.R., Kehoe K.E., and Imani F. Protein kinase R regulates double-stranded RNA induction of TNF-alpha but not IL-1 beta mRNA in human epithelial cells. J. Immunol. 168 12 (2002) 6429-6435
    • (2002) J. Immunol. , vol.168 , Issue.12 , pp. 6429-6435
    • Meusel, T.R.1    Kehoe, K.E.2    Imani, F.3
  • 37
    • 0036833427 scopus 로고    scopus 로고
    • Early postoperative compensatory anti-inflammatory response syndrome is associated with septic complications after major surgical trauma in patients with cancer
    • Mokart D., Capo C., Blache J.L., Delpero J.R., Houvenaeghel G., Martin C., and Mege J.L. Early postoperative compensatory anti-inflammatory response syndrome is associated with septic complications after major surgical trauma in patients with cancer. Br. J. Surg. 89 11 (2002) 1450-1456
    • (2002) Br. J. Surg. , vol.89 , Issue.11 , pp. 1450-1456
    • Mokart, D.1    Capo, C.2    Blache, J.L.3    Delpero, J.R.4    Houvenaeghel, G.5    Martin, C.6    Mege, J.L.7
  • 38
    • 0027945834 scopus 로고
    • The role of LGL/NK cells in surgery-induced promotion of metastasis and its attenuation by morphine
    • Page G.G., Ben-Eliyahu S., and Liebeskind J.C. The role of LGL/NK cells in surgery-induced promotion of metastasis and its attenuation by morphine. Brain. Behav. Immun. 8 3 (1994) 241-250
    • (1994) Brain. Behav. Immun. , vol.8 , Issue.3 , pp. 241-250
    • Page, G.G.1    Ben-Eliyahu, S.2    Liebeskind, J.C.3
  • 39
    • 0027264039 scopus 로고
    • Morphine attenuates surgery-induced enhancement of metastatic colonization in rats
    • Page G.G., Ben Eliyahu S., Yirmiya R., and Liebeskind J.C. Morphine attenuates surgery-induced enhancement of metastatic colonization in rats. Pain 54 1 (1993) 21-28
    • (1993) Pain , vol.54 , Issue.1 , pp. 21-28
    • Page, G.G.1    Ben Eliyahu, S.2    Yirmiya, R.3    Liebeskind, J.C.4
  • 42
    • 0035501605 scopus 로고    scopus 로고
    • Diurnal changes in lung tumor clearance and their relation to NK cell cytotoxicity in the blood and spleen
    • Shakhar G., Bar-Ziv I., and Ben-Eliyahu S. Diurnal changes in lung tumor clearance and their relation to NK cell cytotoxicity in the blood and spleen. Int. J. Cancer 94 3 (2001) 401-406
    • (2001) Int. J. Cancer , vol.94 , Issue.3 , pp. 401-406
    • Shakhar, G.1    Bar-Ziv, I.2    Ben-Eliyahu, S.3
  • 43
    • 0032055982 scopus 로고    scopus 로고
    • In vivo beta-adrenergic stimulation suppresses natural killer activity and compromises resistance to tumor metastasis in rats
    • Shakhar G., and Ben-Eliyahu S. In vivo beta-adrenergic stimulation suppresses natural killer activity and compromises resistance to tumor metastasis in rats. J. Immunol. 160 7 (1998) 3251-3258
    • (1998) J. Immunol. , vol.160 , Issue.7 , pp. 3251-3258
    • Shakhar, G.1    Ben-Eliyahu, S.2
  • 44
    • 1542649477 scopus 로고    scopus 로고
    • Potential prophylactic measures against postoperative immunosuppression: could they reduce recurrence rates in oncological patients?
    • Shakhar G., and Ben-Eliyahu S. Potential prophylactic measures against postoperative immunosuppression: could they reduce recurrence rates in oncological patients?. Ann. Surg. Oncol. 10 8 (2003) 972-992
    • (2003) Ann. Surg. Oncol. , vol.10 , Issue.8 , pp. 972-992
    • Shakhar, G.1    Ben-Eliyahu, S.2
  • 45
    • 33846633686 scopus 로고    scopus 로고
    • Shakhar, G., Abudarham, N., Melamed, R., Schwartz, Y., Rosenne, E., Ben-Eliyahu, S. 2006. Amelioration of operation-induced suppression of marginating pulmonary NK activity using poly IC: a potential approach to reduce post operative metastasis. Ann. Surg. Oncol. PMID 17091332 (in press).
  • 46
    • 0036568525 scopus 로고    scopus 로고
    • Kinetics of the early recruitment of leukocyte subsets at the sites of tumor cells in the lungs: natural killer (NK) cells rapidly attract monocytes but not lymphocytes in the surveillance of micrometastasis
    • Shingu K., Helfritz A., Kuhlmann S., Zielinska-Skowronek M., Jacobs R., Schmidt R.E., Pabst R., and von Horsten S. Kinetics of the early recruitment of leukocyte subsets at the sites of tumor cells in the lungs: natural killer (NK) cells rapidly attract monocytes but not lymphocytes in the surveillance of micrometastasis. Int. J. Cancer 99 1 (2002) 74-81
    • (2002) Int. J. Cancer , vol.99 , Issue.1 , pp. 74-81
    • Shingu, K.1    Helfritz, A.2    Kuhlmann, S.3    Zielinska-Skowronek, M.4    Jacobs, R.5    Schmidt, R.E.6    Pabst, R.7    von Horsten, S.8
  • 47
    • 0027512228 scopus 로고
    • Tumor necrosis factor produces homologous desensitization of lymphocyte beta 2-adrenergic responses
    • Singh M., Notterman D.A., and Metakis L. Tumor necrosis factor produces homologous desensitization of lymphocyte beta 2-adrenergic responses. Circ. Shock 39 4 (1993) 275-278
    • (1993) Circ. Shock , vol.39 , Issue.4 , pp. 275-278
    • Singh, M.1    Notterman, D.A.2    Metakis, L.3
  • 48
    • 16244369167 scopus 로고    scopus 로고
    • Strategies for the prevention and treatment of peritoneal carcinomatosis from gastrointestinal cancer
    • Sugarbaker P.H. Strategies for the prevention and treatment of peritoneal carcinomatosis from gastrointestinal cancer. Cancer Invest. 23 2 (2005) 155-172
    • (2005) Cancer Invest. , vol.23 , Issue.2 , pp. 155-172
    • Sugarbaker, P.H.1
  • 49
    • 0032127376 scopus 로고    scopus 로고
    • Natural killer cell activity in patients with hepatocellular carcinoma: a new prognostic indicator after hepatectomy
    • Taketomi A., Shimada M., Shirabe K., Kajiyama K., Gion T., and Sugimachi K. Natural killer cell activity in patients with hepatocellular carcinoma: a new prognostic indicator after hepatectomy. Cancer 83 1 (1998) 58-63
    • (1998) Cancer , vol.83 , Issue.1 , pp. 58-63
    • Taketomi, A.1    Shimada, M.2    Shirabe, K.3    Kajiyama, K.4    Gion, T.5    Sugimachi, K.6
  • 50
    • 0035123548 scopus 로고    scopus 로고
    • Prognostic significance of natural killer cell activity in patients with gastric carcinoma: a multivariate analysis
    • Takeuchi H., Maehara Y., Tokunaga E., Koga T., Kakeji Y., and Sugimachi K. Prognostic significance of natural killer cell activity in patients with gastric carcinoma: a multivariate analysis. Am. J. Gastroenterol. 96 2 (2001) 574-578
    • (2001) Am. J. Gastroenterol. , vol.96 , Issue.2 , pp. 574-578
    • Takeuchi, H.1    Maehara, Y.2    Tokunaga, E.3    Koga, T.4    Kakeji, Y.5    Sugimachi, K.6
  • 53
    • 1342343087 scopus 로고    scopus 로고
    • A phase II trial of interleukin-12 in patients with advanced cervical cancer: clinical and immunologic correlates. Eastern Cooperative Oncology Group study E1E96
    • Wadler S., Levy D., Frederickson H.L., Falkson C.I., Wang Y., Weller E., Burk R., Ho G., and Kadish A.S. A phase II trial of interleukin-12 in patients with advanced cervical cancer: clinical and immunologic correlates. Eastern Cooperative Oncology Group study E1E96. Gynecol. Oncol. 92 3 (2004) 957-964
    • (2004) Gynecol. Oncol. , vol.92 , Issue.3 , pp. 957-964
    • Wadler, S.1    Levy, D.2    Frederickson, H.L.3    Falkson, C.I.4    Wang, Y.5    Weller, E.6    Burk, R.7    Ho, G.8    Kadish, A.S.9
  • 54
    • 0034758549 scopus 로고    scopus 로고
    • Surgical strategies and minimal residual disease detection
    • Weitz J., and Herfarth C. Surgical strategies and minimal residual disease detection. Semin. Surg. Oncol. 20 4 (2001) 329-333
    • (2001) Semin. Surg. Oncol. , vol.20 , Issue.4 , pp. 329-333
    • Weitz, J.1    Herfarth, C.2
  • 55
    • 0025647947 scopus 로고
    • Effects of beta-adrenergic receptor activation, cholera toxin and forskolin on human natural killer cell function
    • Whalen M.M., and Bankhurst A.D. Effects of beta-adrenergic receptor activation, cholera toxin and forskolin on human natural killer cell function. Biochem. J. 272 2 (1990) 327-331
    • (1990) Biochem. J. , vol.272 , Issue.2 , pp. 327-331
    • Whalen, M.M.1    Bankhurst, A.D.2
  • 56
    • 4143131229 scopus 로고    scopus 로고
    • Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activity
    • Whitmore M.M., DeVeer M.J., Edling A., Oates R.K., Simons B., Lindner D., and Williams B.R. Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activity. Cancer Res. 64 16 (2004) 5850-5860
    • (2004) Cancer Res. , vol.64 , Issue.16 , pp. 5850-5860
    • Whitmore, M.M.1    DeVeer, M.J.2    Edling, A.3    Oates, R.K.4    Simons, B.5    Lindner, D.6    Williams, B.R.7
  • 57
    • 0346749331 scopus 로고    scopus 로고
    • Natural killer cells and cancer
    • Wu J., and Lanier L.L. Natural killer cells and cancer. Adv. Cancer Res. 90 (2003) 127-156
    • (2003) Adv. Cancer Res. , vol.90 , pp. 127-156
    • Wu, J.1    Lanier, L.L.2
  • 59
    • 0031969264 scopus 로고    scopus 로고
    • Angiogenesis and tumor metastasis
    • Zetter B.R. Angiogenesis and tumor metastasis. Annu. Rev. Med. 49 (1998) 407-424
    • (1998) Annu. Rev. Med. , vol.49 , pp. 407-424
    • Zetter, B.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.