Specific methylation and epoxidation of sinenxan A by Mucor genevensis and the multi-drug resistant tumor reversal activities of the metabolites

Journal of Molecular Catalysis B: Enzymatic

Volumn 46, Issue 1-4, 2007, Pages 8-13

  Yang, Lin ^a,b   Qu, Runjiang ^a   Dai, Jungui ^a   Chen, Xiaoguang ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b MINZU UNIVERSITY OF CHINA   (China)

Author keywords

Biotransformation; Mucor genevensis; Taxanes; Tumor MDR reversal activity

Indexed keywords

MUCOR GENEVENSIS; MULTI-DRUG RESISTANCE (MDR); TAXANE; TUMOR CELLS; TUMOR MDR REVERSAL ACTIVITY;

EPOXIDATION; METABOLITES; METHYLATION; TISSUE CULTURE; TUMORS;

CATALYSTS;

10BETA HYDROXY 2ALPHA,5ALPHA,14BETA TRIACETOXY 4BETA,20 EPOXYTAXA 11(12) ENE; 10BETA HYDROXY 2ALPHA,5ALPHA,14BETA TRIACETOXYTAXA 4(20),11 DIENE; 10BETA METHOXY 2ALPHA,5ALPHA,14BETA TRIACETOXYTAXA 4(20),11 DIENE; 2ALPHA,5ALPHA,10BETA,14BETA TETRAACETOXY 4BETA,20 EPOXYTAXA 11(12) ENE; 2ALPHA,5ALPHA,10BETA,14BETA TETRAACETOXYTAXA 4(20),11 DIENE; 6ALPHA HYDROXY 2ALPHA,5ALPHA,10BETA,14BETA TETRAACETOXY 4BETA,20 EPOXYTAXA 11(12) ENE; 6ALPHA HYDROXY 2ALPHA,5ALPHA,10BETA,14BETA TETRAACETOXYTAXA 4(20),11 DIENE; 6ALPHA,10BETA DIHYDROXY 2ALPHA,5ALPHA,14BETA TRIACETOXYTAXA 4(20),11 DIENE; 9ALPHA HYDROXY 2ALPHA,5ALPHA,10BETA,14BETA TETRAACETOXYTAXA 4(20),11 DIENE; 9ALPHA,10BETA DIHYDROXY 2ALPHA,5ALPHA,14BETA TRIACETOXYTAXA 4(20),11 DIENE; 9ALPHA,10BETA O (PROPANE 2,2 DIYL) 2ALPHA,5ALPHA,14BETA TRIACETOXYTAXA 4(20),11 DIENE; PACLITAXEL; TAXOID; UNCLASSIFIED DRUG; VERAPAMIL;

ARTICLE; BIOTRANSFORMATION; CALLUS CULTURE; CHEMICAL ANALYSIS; CONTROLLED STUDY; EPOXIDATION; HUMAN; HUMAN CELL; METHYLATION; MUCOR; MULTIDRUG RESISTANCE; SPECTROSCOPY; TISSUE CULTURE; TUMOR CELL;

MUCOR GENEVENSIS; TAXUS;

EID: 34047095358     PISSN: 13811177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcatb.2007.01.007     Document Type: Article

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