Interleukin-6, interleukin-10 and heat shock protein-90 expression in renal epithelial neoplasias and surrounding normal-appearing renal parenchyma

International Journal of Immunopathology and Pharmacology

Volumn 20, Issue 1, 2007, Pages 37-46

  Cardillo, Maria Rosaria ^a   Ippoliti, F ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

HSP 90; IL 10; IL 6; Immunohistochemistry; Renal cell carcinoma

Indexed keywords

BIOLOGICAL MARKER; HEAT SHOCK PROTEIN 90; INTERLEUKIN 10; INTERLEUKIN 6; TUMOR MARKER;

ADULT; AGED; ARTICLE; BENIGN TUMOR; CANCER GROWTH; CANCER STAGING; CONTROLLED STUDY; CYTOKINE PRODUCTION; GLEASON SCORE; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KIDNEY CARCINOMA; KIDNEY TUMOR; MAJOR CLINICAL STUDY; NEPHRECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 33947732393     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463200702000105     Document Type: Article

References (45)

1. Jacobsohn K.M. and C.G. Wood. 2006. Adjuvant therapy for renal cell carcinoma. Semin. Oncol. 33:576.
2. Agnieszka M. and S.P. Hardev. 2003. Renal-cell carcinoma: tumor markers, T-cell epitopes, and potential for new therapies. Lancet Oncol. 4:215.
3. Eble J.N., G. Sauter, J.I. Epstein and I.A. Sesterhen. 2004. Pathology and genetics of Tumours of the Urinary System and Male genital Organs. WHO IARC Press Lyon p. 12.
4. Havranek E., W.M. Howell, H.M. Fussell, J.A. Whelan, M.A. Whelan and H.S. Pandha. 2005. An interleukin-10 promoter polymorphism may influence tumor development in renal cell carcinoma. J. Urol. 173:709.
5. Cardillo M.R., D. Lazzereschi, O. Gandini, F. Di Silverio and G. Colletta. 2001. Transforming growth factor-β pathway in human renal cell carcinoma and surrounding normal-appearing renal parenchyma. Anal. Quant. Cytol. Histol. 23:109.
6. Cardillo M.R., P. Sale and F. Di Silverio. 2000. Heat shock protein-90, IL-6 and IL-10 in bladder cancer. Anticancer Res. 20:4579.
7. Cardillo M.R. and F. Ippoliti. 2006. IL-6, IL-10 and HSP-90 expression in tissue microarrays from human prostate cancer assessed by computer-assisted image analysis. Anticancer Res. 26:3409.
8. Nagata J., H. Kijima, H. Hatanaka, T. Tokunaga, A. Takagi, T. Mine, H. Yamazaki, M. Nakamura and Y. Ueyama. 2002. Correlation between interleukin 10 and vascular endothelial growth factor expression in human esophageal cancer. Int. J. Mol. Med. 10:169.
9. Culig Z., H. Steiner, G. Bartsch and A. Hobish. 2005. Interleukin-6 regulation of prostate cancer cell growth. J. Cell. Biochem. 95:497.
10. Morcellin S., E. Wang and F.M. Marincola. 2004. Cytokines and immune response in the tumor microenvironment. J. Immunother. 24:392.
11. Mocellin S., F.M. Marincola and H.A. Young. 2005 Interleukin-10 and the immune response against cancer: a counterpoint. J. Leukoc. Biol. 78:1043.
12. Roncarolo M.G., R. Bacchetta, C. Bordignon, S. Narula and M.K. Levings. 2001. Type 1 T regulatory cells. Review. Immunol. Rev. 182:68.
13. Isaacs J.S., W. Xu and L. Neckers. 2003. Heat shock protein 90 as a molecular target for cancer therapeutics. Cancer Cell 3:213.
14. Cullinan S.B. and L. Whitesell. 2006. Heat shock protein 90: a unique chemotherapeutic target. Review Semin. Oncol. 33:457.
15. Burrows F., H. Zhang and A. Kamal. 2004. Hsp90 activation and cell cycle regulation. Cell Cycle 3:1530.
16. Drysdale M.J., P.A. Brough, A. Massey, M.R. Jensen and J. Schoepfer. 2006. Targeting Hsp90 for the treatment of cancer. Review. Curr. Opin. Drug Discov. Devel. 9:483.
17. Zhang H. and F. Burrows. 2004. Targeting multiple signal transduction pathways through inhibition of Hsp90. J. Mol. Med. 82:488.
18. Chen Y. and J. Ding. 2004. Heat shock protein 90: novel target for cancer therapy. Ai Zheng 23:968.
19. Luo L.Y., I. Herrera, E.P. Soosaipillai and E.P. Diamandis. 2002. Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of ovarian carcinoma expression library. Br. J. Cancer 87:339.
20. Lim S.O., S.G. Park, J.H. Yoo, Y.M. Park, H.J. Kim, K.T. Jang, J.W. Cho, B.C. Yoo, G.H. Jung and C.K. Park. 2005. Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules. World J. Gastroenterol. 11:2072.
21. Schueller G., J. Kettenbach, R. Sedivy, H. Bergmeister, A. Stift, J. Fried, M. Gnant and J. Lammer. 2004. Expression of heat shock proteins in human hepatocellular carcinoma after radiofrequency ablation in animal. Oncol. Rep. 12:495.
22. Ibrahim N.O., T. Hahn, C. Franke, D.P. Stlehl, R. Wirthner, R.H. Wenger and D.M. Katschinski. 2005. Induction of the hypoxia-inducible factor system by low levels of heat shock protein 90 inhibitors. Cancer Res. 65:11094.
23. Isaacs J.S., Y.J. Jung, E.G. Mimnaugh, A. Martinez and F. Cuttitta. 2002. HSP90 regulates a von Hippel Lindau-independent hypoxia-inducibile factor-1α-degradative pathway. J. Biol. Chem. 277:29936.
24. Ramirez U., N. Uribe, R. Garcia-Torres, C. Castro, J. Rubio, G. Gambaand and N.A. Bobadilla. 2004. Upregulation and intrarenal redistribution of heat shock proteins 90alpha and 90beta by low-sodium diet in the rat. Cell Stress Chaperones 9:198.
25. Whitesell L. and S.L. Lindquist. 2005. HSP90 and the chaperoning of cancer. Nat. Rev. Cancer 5:761.
26. Angelo L.S., M. Talpaz and R. Kurzrock. 2002. Autocrine interleukin-6 production in renal cell carcinoma: evidence for involvement of p53. Cancer Res. 62:932.
27. Alberti L., T. Bachelot, A. Due, C. Biota and J.Y. Blay. 2005. A spliced isoform of interleukin 6 mRNA produced by renal cell carcinoma encodes for an interleukin 6 inhibitor. Cancer Res. 65:2.
28. Yoshida N., S. Ikemoto, K. Narika, K. Sugimura, S. Wada, R. Yasumoto, T. Kishimoto and T. Nakatani. 2002. Interleukin-6, tumor necrosis factor α and interleukin -1β in patients with renal cell carcinoma. Br. J. Cancer 86:1396.
29. American Joint Committeee on Cancer. Cancer Staging Manual 6th ed. 2002 Philadelphia: Lippincott-Raven.
30. Fuhrmann S.A., L.C. Lasky and C. Limas. 1982 Prognostic significance of morphologic parameters in renal cell carcinoma. Am. J. Surg. Pathol. 6:655.
31. Cardillo M.R., F. Di Silverio and V. Gentile. 2005. Quantitative immunohistochemical and in situ hybridization analysis of metalloproteinases in prostatic cancer. Anticancer Res. 26:3.
32. Konig B., F. Steinbach, B. Janocha, A. Drynda, M. Stumm, C. Philipp, E.P. Allhoff and W. Konig. 1999. The differential expression of proinflammatory cytokines IL-6, IL-8 and TNF-alpha in renal cell carcinoma. Anticancer Res. 19:1519.
33. Chang S.G., S.J. Lee, J.I. Kim, J.C. Jung, J.H. Kim and R.M. Hoffman. 1997. Interleukin-6 production in primary histoculture by normal human kidney and renal tumor tissues. Anticancer Res. 17:113.
34. Mourad W.A., B.R. Nestok, G.Y. Saleh, K. Silez, R.F. Power and L.D. Jewell. 1994. Dysplastic tubular epithelium in "normal"kidney associated with renal cell carcinoma. Am. J. Surg. Pathol. 18:1117.
35. Lahn M., P. Fisch, G. Kohlerv, R. Kunzmann, I. Hentrich, H. Jesuiter, D. Behringer, B. Muschal, H. Veelken, P. Kulmburg, D.N. Iklé and A. Lindermann. 1999. Pro-inflammatory and T cell inhibitory cytokines are secreted at high levels in tumor cell cultures oh human renal cell carcinoma. Eur. Urol. 35:70.
36. Knoefel B., K. Nuske, T. Steiner, K. Junker, H. Kosmehl, K. Rebstock, D. Reinhold and U. Junker. 1997. Renal cell carcinomas produce IL-6, IL-10, IL-11 and TGF-β1 in primary cultures and modulate T lymphocyte blast transformation. J. Interferon Cytokine Res. 17:95.
37. Uwatoko N., T. Tokunaga, H. Hatanaka, H. Osada, T. Kawakami, H. Yamakazi, Y. Abe, H. Kijima, Y. Ueyama and M. Nakamura. 2002. Expression of interleukin-10 is inversely correlated with distant metastasis of renal cell carcinoma. Int. J. Oncol. 20:729.
38. Ikemoto S., K. Sugimura, N. Yoshida, N. Wada, S. Wada, K. Yamamoto and T. Kishimoto. 2000. TNFα, IL-1β and IL-6 production by peripheral blood monocytes in patients with renal cell carcinoma. Anticancer Res. 20:317.
39. Negrier S., D. Perol, C. Menetrier-Caux, B. Escudier, M. Pallardy, A. Ravaud, J.Y. Douillard, C. Chevreau, C. Lasset and J.Y. Bay. 2004. Interleukin-6, Interleukin-10, and vascular endothelial growth factor in metastatic renal cell carcinoma: prognostic value of interleukin-6 from the groupe francais d'immunologie. J. Clin. Oncol. 22:2371.
40. Basturk B., I. Yavascaoglu, H. Vuruskan, G. Goral, B. Oktay and B. Oral. 2005. Cytokine gene polymorphisms as potential risk and protective factors in renal cell carcinoma. Cytokine 30:41.
41. Olive C., C. Cheung, D. Nicol and M.C. Falk. 1998. Expression of cytokine mRNA transcripts in renal cell carcinoma. Immunol. Cell. Biol. 76:357.
42. Onishi T., Y. Ohisi, K. Imagawa, Y. Ohomoto and K. Murata. 1999. An assessment of immunological environment based on intratumoral cytokine production in renal cell carcinoma. BJU Int. 83:488.
43. Sato N., T. Yamamoto, Y. Sekine, T. Yumioka, A. Junicho, H. Fuse and T. Matsuda. 2003. Involvement of heat-shock protein 90 in the interleuki-6-mediated signaling pathway through STAT3. Biochem. Biophys. Res. Commun. 300:847.
44. Pieper M., H.D. Rupprecht, K.M. Bruch, E. De Heer and H.O. Schocklmann. 2000. Requirement of heat shock protein 90 in mesangial cell mitogenesis. Kidney Int. 58:2377.
45. Healy D.A., N.G. Docherty, M. Murphy, J.M. Fitzpatrick and R.W. Warton. 2006. Heat shock-induced protection of renal proximal tubular epithelial cells from cold storage and rewarming injury. J. Am. Soc. Nephrol. 17:805.