Interleukin-18/interleukin-10 ratio is an independent predictor of recurrent coronary events during a 1-year follow-up in patients with acute coronary syndrome

International Journal of Cardiology

Volumn 117, Issue 3, 2007, Pages 333-339

  Chalikias, Georgios K ^a   Tziakas, Dimitrios N ^a   Kaski, Juan Carlos ^b   Kekes, Angelos ^a   Hatzinikolaou, Eleni I ^a   Stakos, Dimitrios A ^a   Tentes, Ioannis K ^a   Kortsaris, Alexandros X ^a   Hatseras, Dimitrios I ^a  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

ACS prognosis; Acute coronary syndrome; Inflammation; Interleukin 10; Interleukin 18

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 18;

ACUTE CORONARY SYNDROME; ADULT; AGED; ARTICLE; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE COURSE; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HEART DEATH; HEART INFARCTION; HOSPITAL READMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; RECURRENCE RISK; UNSTABLE ANGINA PECTORIS;

AGED; ANGINA, UNSTABLE; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTERLEUKIN-10; INTERLEUKIN-18; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PREDICTIVE VALUE OF TESTS; RECURRENCE; TIME FACTORS;

EID: 33947729561     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2006.05.017     Document Type: Article

References (28)

1. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 340 (1999) 115-126
2. Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 104 (2001) 365-372
3. Tedgui A., and Mallat Z. Interleukin-10: an anti-atherogenic cytokine?. Eur J Clin Invest 31 (2001) 1-2
4. Mallat Z., Besnard S., Duriez M., et al. Protective role of interleukin-10 in atherosclerosis. Circ Res 85 (1999) e17-e24
5. Pinderski Oslund L.J., Hedrick C.C., et al. Interleukin-10 blocks atherosclerotic events in vitro and in vivo. Atheroscler Thromb Vasc Biol 19 (1999) 2847-2853
6. Mallat Z., Henry P., Alouani S., et al. Increased plasma concentrations of interleukin-18 in acute coronary syndromes. Heart 88 (2002) 467-469
7. Smith D.A., Irving S.D., Sheldon J., Cole D., and Kaski J.C. Serum levels of the anti inflammatory cytokine interleukin-10 are decreased in patients with unstable angina. Circulation 104 (2001) 746-749
8. Blankenberg S., Tiret L., Bickel C., et al. Interleukin 18 is a strong predictor of cardiovascular death in stable and unstable angina. Circulation 106 (2002) 24-30
9. Heeschen C., Dimmeler S., Hamm C.W., et al. Serum level of the anti inflammatory cytokine interleukin-10 is an important prognostic determinant in patients with acute coronary syndromes. Circulation 107 (2003) 2109-2114
10. Waehre T., Halvorsen B., Damas J.K., et al. Inflammatory imbalance between IL-10 and TNF-α in unstable angina potential plaque stabilizing effects of IL-10. Eur J Clin Invest 32 (2002) 803-810
11. Chalikias G.K., Tziakas D.N., Kaski J.C., et al. Interleukin-18:Interleukin-10 ratio and in-hospital adverse events in patients with acute coronary syndrome. Atherosclerosis 182 (2005) 135-143
12. Alam S.E., Nasser S.S., Fernainy K.E., Habib A.A., and Badr K.F. Cytokine imbalance in acute coronary syndrome. Curr Opin Pharmacol 4 (2004) 166-170
13. Myocardial infarction redefined-a consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. Eur Heart J 21 (2000) 1502-1513
14. Braunwald E. Unstable angina: a classification. Circulation 80 (1989) 410-414
15. Ledue T.B., Weiner D.L., Sipe J.D., Poulin S.E., Collins M.F., and Rifai N. Analytical evaluation of particle enhanced immunonephelometric assays for C-reactive protein, serum amyloid A and mannose-binding protein in human serum. Ann Clin Biochem 35 (1998) 745-753
16. Wang P., Wu P., Siegel M.I., Egan R.W., and Billah M.M. Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes: IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J Biol Chem 270 (1995) 9558-9563
17. Lacraz S., Nicol L.P., Chicheportiche R., Welgus H.G., and Dayer J.M. IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes. J Clin Invest 96 (1995) 2304-2310
18. Lindmark E., Tenno T., Chen J., and Siegbahn A. IL-10 inhibits LPS-induced human monocyte tissue factor expression in whole blood. Br J Haematol 102 (1998) 597-604
19. Terkeltaub R.A. IL-10: an "Immunologic scalpel" for atherosclerosis?. Arterioscler Thromb Vasc Biol 19 (1999) 2823-2825
20. Ajuebor M.N., Das A.M., Virag L., Flower R.J., Szabo C., and Peretti M. Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10. J Immunol 162 (1999) 1685-1691
21. Mallat Z., Heymes C., Ohan J., Faggin E., Leseche G., and Tedgui A. Expression of interleukin-10 in advanced human atherosclerotic plaques. Arterioscler Thromb Vasc Biol 19 (1999) 611-616
22. Okamura H., Tsutsi H., Komatsu T., et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 378 (1995) 88-91
23. Vidal-Vanaclocha F., Fantuzzi G., Mendoza L., et al. IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1. Proc Natl Acad Sci U S A 97 (2000) 734-739
24. Puren A.J., Fantuzzi G., Gu Y., Su M.S., and Dinarello C.A. Interleukin-18 (IFN gamma-inducing factor) induces IL-8 and IL-1 beta via TNF-alpha production from non-CD14+ human blood mononuclear cells. J Clin Invest 101 (1998) 711-721
25. Mallat Z., Corbaz A., Scoazec A., et al. Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability. Circulation 104 (2001) 1598-1603
26. Brennan F.M. Interleukin-10 and arthritis. Rheumatology 38 (1999) 293-297
27. Papadakis K.A., and Targan S.R. Role of cytokines in the pathogenesis of inflammatory bowel disease. Annu Rev Med 51 (2000) 298
28. Uyemura K., Demer L.L., Castle S.C., et al. Cross regulatory roles of interleukin-12 and interleukin-10 in atherosclerosis. J Clin Invest 97 (1996) 2130-2138