Heterodimeric Amino Acid Transporters in the Placenta - A Workshop Report

Placenta

Volumn 28, Issue SUPPL., 2007, Pages

  Regnault, T R H ^a   Kudo, Y ^b   Glazier, J ^c   Roos, S ^d   Lewis, R M ^e   Jansson, T ^f  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b HIROSHIMA UNIVERSITY   (Japan)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

^e UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^f UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Amino acid; Heterodimeric amino acid transport; Homocysteine; Leucine; mTOR; Placenta; System L; System y+

Indexed keywords

AMINO ACID; AMINO ACID TRANSPORTER; HOMOCYSTEINE; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA;

AMINO ACID TRANSPORT; ARTICLE; BLOOD PLACENTA BARRIER; CYTOTROPHOBLAST; FETUS CIRCULATION; FETUS GROWTH; GENE EXPRESSION; HUMAN; INTRAUTERINE GROWTH RETARDATION; MICROVILLUS; MOLECULAR BIOLOGY; PLACENTA; PLACENTA CIRCULATION; PLACENTAL TRANSFER; PREECLAMPSIA; PREGNANCY COMPLICATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SYNCYTIOTROPHOBLAST; TROPHOBLAST;

AMINO ACID TRANSPORT SYSTEMS; ANIMALS; DIMERIZATION; FEMALE; HOMOCYSTEINE; HUMANS; LEUCINE; PLACENTA; PREGNANCY;

EID: 33947727050     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.placenta.2007.02.003     Document Type: Article

References (20)

1. Broer S., and Wagner C.A. Structure-function relationships of heterodimeric amino acid transporters. Cell Biochem Biophys 36 2-3 (2002) 155-168
2. Kudo Y., and Boyd C.A. Heterodimeric amino acid transporters: expression of heavy but not light chains of CD98 correlates with induction of amino acid transport systems in human placental trophoblast. J Physiol 523 Pt 1 (2000) 13-18
3. Kanai Y., and Endou H. Heterodimeric amino acid transporters: molecular biology and pathological and pharmacological relevance. Curr Drug Metab 2 4 (2001) 339-354
4. Jansson T. Amino acid transporters in the human placenta. Pediatr Res 49 2 (2001) 141-147
5. Regnault T.R.H., de Vrijer B., and Battaglia F.C. Transport and metabolism of amino acids in placenta. Endocrine 19 1 (2002) 23-41
6. Verrey F., Closs E.I., Wagner C.A., Palacin M., Endou H., and KanaiCATs Y. HATs: the SLC7 family of amino acid transporters. Pflugers Arch 447 5 (Feb 2004) 532-542
7. Babu E., Kanai Y., Chairoungdua A., Kim K., Iribe Y., Tangtrongsup S., et al. Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem 278 44 (2003) 43838-43845
8. Bodoy S., Martin L., Zorzano A., Palacin M., Estevez R., and Bertran J. Identification of LAT4, a novel amino acid transporter with system L activity. J Biol Chem 280 12 (2005) 12002-12011
9. Okamoto Y., Sakata M., Ogura K., Yamamoto T., Yamaguchi M., Tasaka K., et al. Expression and regulation of 4F2hc and hLAT1 in human trophoblasts. Am J Physiol Cell Physiol 282 1 (Jan 2002) C196-C204
10. Kudo Y., and Boyd C.A. Characterisation of L-tryptophan transporters in human placenta: a comparison of brush border and basal membrane vesicles. J Physiol 531 Pt 2 (Mar 1 2001) 405-416
11. Prasad P.D., Wang H., Huang W., Kekuda R., Rajan D.P., Leibach F.H., et al. Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function. Biochem Biophys Res Commun 255 2 (1999) 283-288
12. +L. A candidate gene for lysinuric protein intolerance. J Biol Chem 273 49 (1998) 32437-32445
13. +L induced in Xenopus laevis oocytes by human choriocarcinoma cell (JAR) mRNA is functionally related to the heavy chain of the 4F2 cell surface antigen. Biochemistry 34 27 (1995) 8744-8751
14. Vollset S.E., Refsum H., Irgens L.M., Emblem B.M., Tverdal A., Gjessing H.K., et al. Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study. Am J Clin Nutr 71 4 (2000) 962-968
15. Malinow M.R., Rajkovic A., Duell P.B., Hess D.L., and Upson B.M. The relationship between maternal and neonatal umbilical cord plasma homocyst(e)ine suggests a potential role for maternal homocyst(e)ine in fetal metabolism. Am J Obstet Gynecol 178 2 (1998) 228-233
16. Cetin I., Corbetta C., Sereni L.P., Marconi A.M., Bozzetti P., Pardi G., et al. Umbilical amino acid concentrations in normal and growth-retarded fetuses sampled in utero by cordocentesis. Am J Obstet Gynecol 162 1 (1990) 253-261
17. Jansson T., Scholtbach V., and Powell T.L. Placental transport of leucine and lysine is reduced in intrauterine growth restriction. Pediatr Res 44 4 (Oct 1998) 532-537
18. Thomas G., and Hall M.N. TOR signalling and control of cell growth. Curr Opin Cell Biol 9 6 (Dec 1997) 782-787
19. Kim D.H., Sarbassov D.D., Ali S.M., King J.E., Latek R.R., Erdjument-Bromage H., et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110 2 (2002) 163-175
20. Meier C., Ristic Z., Klauser S., and Verrey F. Activation of system L heterodimeric amino acid exchangers by intracellular substrates. EMBO J 21 4 (2002) 580-589