M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: Serominic compounds

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 9, 2007, Pages 2649-2655

  Suckling, Colin J ^a   Murphy, John A ^a   Khalaf, Abedawn I ^a   Zhou, Sheng ze ^a   Lizos, Dimitris E ^a   van Nhien, Albert Nguyen ^a   Yasumatsu, Hiroshi ^b,c   McVie, Allan ^b   Young, Louise C ^a   McCraw, Corinna ^a   Waterman, Peter G ^a   Morris, Brian J ^b,d   Pratt, Judith A ^a,b   Harvey, Alan L ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

5HT7 receptor antagonist; Amidines; Anti schizophrenic; M4 receptor agonist; Tetrahydroisoquinolines

Indexed keywords

AMIDINE; DOPAMINE 2 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M4 RECEPTOR AGONIST; MUSCARINIC RECEPTOR; NATURAL PRODUCT; NEUROLEPTIC AGENT; PHENCYCLIDINE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PSYCHEDELIC AGENT; SB 2598741; SEROTONIN 7 RECEPTOR; SEROTONIN 7 RECEPTOR ANTAGONIST; SEROTONIN RECEPTOR; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; AMPHETAMINE; ATROPINE; MUSCARINIC AGENT;

ARTICLE; BRAIN METABOLISM; CENTRAL NERVOUS SYSTEM; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG TARGETING; LIGAND BINDING; NEUROCHEMISTRY; NONHUMAN; RECEPTOR AFFINITY; SCHIZOPHRENIA; ANIMAL; BRAIN; CHEMISTRY; CONFORMATION; DRUG DESIGN; DRUG EFFECT; HUMAN; KINETICS; METABOLISM; METHODOLOGY; RAT; SYNTHESIS;

RATTUS;

AMPHETAMINE; ANIMALS; ANTIPSYCHOTIC AGENTS; ATROPINE; BRAIN; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; KINETICS; MOLECULAR CONFORMATION; MUSCARINIC AGONISTS; RATS; RECEPTOR, MUSCARINIC M4; SCHIZOPHRENIA;

EID: 33947726368     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.093     Document Type: Article

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