A glycosylated complex of gadolinium, a new potential contrast agent for magnetic resonance angiography?

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 8, 2007, Pages 2246-2249

  Yu, G ^a   Yamashita, M ^a   Aoshima, K ^a   Takahashi, M ^a   Oshikawa, T ^b   Takayanagi, H ^c   Laurent, S ^d   Burtea, C ^d   Vander Elst, L ^d   Muller, R N ^d  

^a SHIZUOKA UNIVERSITY   (Japan)

^b NUMAZU COLLEGE OF TECHNOLOGY   (Japan)

^c MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^d NMR   (Belgium)

Author keywords

Contrast agent; Gd complexes; MRI

Indexed keywords

GADOLINIUM; OXYGEN 17; PROTON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; LIVER; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; NONHUMAN; RAT; SPLEEN;

ANIMALS; CONTRAST MEDIA; DENDRIMERS; GADOLINIUM; GLYCOSYLATION; LIVER; MAGNETIC RESONANCE ANGIOGRAPHY; MOLECULAR WEIGHT; OXYGEN ISOTOPES; PHARMACOKINETICS; PROTONS; RATS; SPLEEN; TISSUE DISTRIBUTION;

RATTUS;

EID: 33947725270     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.067     Document Type: Article

References (20)

1. Wang S.J., Brechbiel M., and Wiener E.C. Invest. Radiol. 38 10 (2003) 662
2. 20
3. Vander Elst L., Maton F., Laurent S., Seghi F., Chapelle F., and Muller R.N. Magn. Reson. Med. 38 (1997) 604
4. Botteman F., Nicolle G., Vander Elst L., Laurent S., Merbach A.E., and Muller R.N. Eur. J. Inorg. Chem. (2002) 2686
5. Laurent S., Vander Elst L., and Muller R.N. Contrast Med. Mol. Imaging 1 (2006) 128
6. Powell D.H., Ni Dhubhghaill O.M., Pubanz D., Helm L., Lebedev Y.S., Schlaepfer W., and Merbach A.E. J. Am. Chem. Soc. 118 (1996) 9333
7. Muller, R.N.; Declercq, D.; Vallet, P; Giberto, F.; Daminet, B.; Fischer, H.W.; Maton, F.; Van Haverbeke, Y. Proc. ESMRMB, 7th Annual Congress, Strasbourg, 1990; p. 394.
8. Vallet, P. Ph. D. Thesis, University of Mons-Hainaut in Belgium, 1992.
9. Solomon I. Phys. Rev. 99 (1955) 559
10. Bloembergen N.J. Chem. Phys. 27 (1957) 572
11. Freed J.H. J. Chem. Phys. 68 (1978) 4034
12. Vander Elst L., Sessoye A., Laurent S., and Muller R.N. Helv. Chim. Acta 88 (2005) 574
13. Burtea C., Laurent S., Colet J.-M., Vander Elst L., and Muller RN. Invest. Radiol. 38 (2003) 320
14. Cabella C., Geninatti Crich S., Corpillo D., Barge A., Ghirelli C., Bruno E., Lorusso V., Uggen F., and Aime S. Contrast Med. Mol. Imaging 1 (2006) 23
15. Laurent S., Vander Elst L., Copoix F., and Muller R.N. Invest. Radiol. 36 (2001) 115
16. 5 is equal to 0.88 as compared to 0.49 and 0.10 for Gd-DTPA and Gd-DTPA-BMA, respectively.
17. McMurry T.J., Parmelee D.J., Sajiki H., Scott D.M., Outellet H.S., Walovitch RC., Tyeklàr Z., Dumas S., Bernard P., Nadler S., Midelfort K., Greenfield M., Troughton J., and Lauffer R.B. J. Med. Chem. 45 (2002) 3465
18. Prata M.I.M., Santos A.C., Torres S., André J.P., Martins J.A., Neves M., Garcìa-Martín M.L., Rodrigues T.B., López-Larrubia P., Cerdán S., and Geraldes C.F.G.C. Contrast Med. Mol. Imaging 1 (2006) 246
19. Okuhata Y. Adv. Drug Deliv. Rev. 37 (1999) 121
20. Barge A., Cravotto G., Gianolio E., and Fedeli F. Contrast Med. Mol. Imaging 1 (2006) 184