The effect of a phosphodiester linking group on albumin binding, blood half-life, and relaxivity of intravascular diethylenetriaminepentaacetato aquo gadolinium(III) MRI contrast agents

Journal of Medicinal Chemistry

Volumn 45, Issue 16, 2002, Pages 3465-3474

  McMurry, Thomas J ^a   Parmelee, David J ^a   Sajiki, Hironao ^a   Scott, Daniel M ^a   Ouellet, Hillori S ^a   Walovitch, Richard C ^a   Tyeklár, Zoltán ^a   Dumas, Stéphane ^a   Bernard, Paul ^a   Nadler, Samuel ^a   Midelfort, Katarina ^a   Greenfield, Matthew ^a   Troughton, Jeffrey ^a   Lauffer, Randall B ^a  

^a EPIX Medical Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIS(N METHYL DEXTRO GLUCAMINE)[2 (OCTYLDIETHYLENETRIAMINE)DIETHYLENETRIAMINEPENTAACETATO](AQUO)GADOLINIUM; CONTRAST MEDIUM; DIETHYLENETRIAMINEPENTAACETATOAQUO GADOLINIUM DERIVATIVE; PENTETIC ACID DERIVATIVE; TRIS(N METHYL DEXTRO GLUCAMINE)[2 (OCTYLPHOSPHONOOXYMETHYL)DIETHYLENETRIAMINEPENTAACETATO](AQUO)GADOLINIUM; TRISODIUM[2 [(4,4 DIPHENYLCYCLOHEXYL)PHOSPHONOOXYMETHYL]DIETHYLENETRIAMINEPENTAACETATO](AQUO)GADOL INIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; BINDING AFFINITY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG PROTEIN BINDING; HYDROPHILICITY; MALE; MOLECULAR SIZE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; RELAXATION TIME; STRUCTURE ACTIVITY RELATION;

ANIMALS; CONTRAST MEDIA; GADOLINIUM; GADOLINIUM DTPA; HALF-LIFE; MAGNETIC RESONANCE IMAGING; MALE; ORGANOMETALLIC COMPOUNDS; PHOSPHORIC ACID ESTERS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036682251     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0102351     Document Type: Article

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