Inhibition of caveolar uptake, SV40 infection, and β1-integrin signaling by a nonnatural glycosphingolipid stereoisomer

Journal of Cell Biology

Volumn 176, Issue 7, 2007, Pages 895-901

  Singh, Raman Deep ^a   Holicky, Eileen L ^a   Cheng, Zhi Jie ^a   Kim, Seong Youl ^a   Wheatley, Christine L ^a   Marks, David L ^a   Bittman, Robert ^b   Pagano, Richard E ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEXTRO LACTOSYL N OCTANOYL LEVO THREO SPINGOSINE; BETA1 INTEGRIN; GLYCOSPHINGOLIPID; MEMBRANE LIPID; MEMBRANE PROTEIN; SMALL INTERFERING RNA; SPHINGOSINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CAVEOLA; CONTROLLED STUDY; ENDOCYTOSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIMIAN VIRUS 40; SKIN FIBROBLAST; STEREOCHEMISTRY; VIRUS INFECTION;

ANTIGENS, CD; ANTIGENS, CD29; CAVEOLAE; CELL LINE; CELL MEMBRANE; DOWN-REGULATION; ENDOCYTOSIS; GLYCOSPHINGOLIPIDS; HELA CELLS; HUMANS; LACTOSYLCERAMIDES; MEMBRANE MICRODOMAINS; MOLECULAR CONFORMATION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SIMIAN VIRUS 40; STEREOISOMERISM; VIRUS INTERNALIZATION;

EID: 33947717534     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200609149     Document Type: Article

References (32)

1. Anderson, H.A., Y. Chen, and L.C. Norkin. 1996. Bound simian virus 40 translocates to caveolin-enriched membrane domains, and its entry is inhibited by drugs that selectively disrupt caveolae. Mol. Biol. Cell. 7:1825-1834.
2. Arias-Salgado, E.G., S. Lizano, S. Sarkar, J.S. Brugge, M.H. Ginsberg, and S.J. Shattil. 2003. Src kinase activation by direct interaction with the integrin β cytoplasmic domain. Proc. Natl. Acad. Sci. USA. 100:13298-13302.
3. Birkle, S., G. Zeng, L. Gao, R.K. Yu, and J. Aubry. 2003. Role of tumor-associated gangliosides in cancer progression. Biochimie. 85:455-463.
4. Chen, Y., and L.C. Norkin. 1999. Extracellular simian virus 40 transmits a signal that promotes virus enclosure within caveolae. Exp. Cell Res. 246:83-90.
5. Cheng, Z.J., R.D. Singh, D.L. Marks, and R.E. Pagano. 2006a. Membrane microdomains, caveolae, and caveolar endocytosis of sphingolipids. Mol. Membr. Biol. 23:101-110.
6. Cheng, Z.J., R.D. Singh, D.K. Sharma, E.L. Holicky, K. Hanada, D.L. Marks, and R.E. Pagano. 2006b. Distinct mechanisms of clathrin-independent endocytosis have unique sphingolipid requirements. Mol. Biol. Cell. 17:3197-3210.
7. Guerrera, M., and S. Ladisch. 2003. N-butyldeoxynojirimycin inhibits murine melanoma cell ganglioside metabolism and delays tumor onset. Cancer Lett. 201:31-40.
8. Johannes, L., and C. Lamaze. 2002. Clathrin-dependent or not: is it still the question? Traffic. 3:443-451.
9. Kirkham, M., and R.G. Parton. 2005. Clathrin-independent endocytosis: new insights into caveolae and non-caveolar lipid raft carriers. Biochim. Biophys. Acta. 1746:349-363.
10. Kirkham, M., A. Fujita, R. Chadda, S.J. Nixon, T.V. Kurzchalia, D.K. Sharma, R.E. Pagano, J.F. Hancock, S. Mayor, and R.G. Parton. 2005. Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles. J. Cell Biol. 168:465-476.
11. Lamaze, C., A. Dujeancourt, T. Baba, C.G. Lo, A. Benmerah, and A. Dautry-Varsat. 2001. Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway. Mol. Cell. 7:661-671.
12. London, E., and D.A. Brown. 2000. Insolubility of lipids in triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts). Biochim. Biophys. Acta. 1508:182-195.
13. Luque, A., M. Gomez, W. Puzon, Y. Takada, F. Sanchez-Madrid, and C. Cabanas. 1996. Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355-425) of the common beta 1 chain. J. Biol. Chem. 271:11067-11075.
14. Memmo, L.M., and P. McKeown-Longo. 1998. The alphavbeta5 integrin functions as an endocytic receptor for vitronectin. J. Cell Sci. 111:425-433.
15. Mineo, C., and R.G. Anderson. 2001. Potocytosis. Robert Feulgen Lecture. Histochem. Cell Biol. 116:109-118.
16. Nichols, B.J., and J. Lippincott-Schwartz. 2001. Endocytosis without clathrin coats. Trends Cell Biol. 11:406-412.
17. Parton, R.G., B. Joggerst, and K. Simons. 1994. Regulated internalization of caveolae. J. Cell Biol. 127:1199-1215.
18. Pelkmans, L., and A. Helenius. 2002. Endocytosis via caveolae. Traffic. 3:311-320.
19. Pelkmans, L., J. Kartenbeck, and A. Helenius. 2001. Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER. Nat. Cell Biol. 3:473-483.
20. Pelkmans, L., E. Fava, H. Grabner, M. Hannus, B. Habermann, E. Krausz, and M. Zerial. 2005. Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Nature. 436:78-86.
21. Rajendran, L., and K. Simons. 2005. Lipid rafts and membrane dynamics. J. Cell Sci. 118:1099-1102.
22. Sabharanjak, S., P. Sharma, R.G. Parton, and S. Mayor. 2002. GPI-anchored proteins are delivered to recycling endosomes via a distinct cdc42-regulated, clathrin-independent pinocytic pathway. Dev. Cell. 2:411-423.
23. Sharma, D.K., J.C. Brown, A. Choudhury, T.E. Peterson, E. Holicky, D.L. Marks, R. Simari, R.G. Parton, and R.E. Pagano. 2004. Selective stimulation of caveolar endocytosis by glycosphingolipids and cholesterol. Mol. Biol. Cell. 15:3114-3122.
24. Sharma, D.K., J.C. Brown, Z. Cheng, E.L. Holicky, D.L. Marks, and R.E. Pagano. 2005. The glycosphingolipid, lactosylceramide, regulates beta1-integrin clustering and endocytosis. Cancer Res. 65:8233-8241.
25. Simons, K., and R. Ehehalt. 2002. Cholesterol, lipid rafts, and disease. J. Clin. Invest. 110:597-603.
26. Singh, R.D., V. Puri, J.T. Valiyaveettil, D.L. Marks, R. Bittman, and R.E. Pagano. 2003. Selective caveolin-1-dependent endocytosis of glycosphingolipids. Mol. Biol. Cell. 14:3254-3265.
27. Singh, R.D., Y. Liu, C.L. Wheatley, E.L. Holicky, A. Makino, D.L. Marks, T. Kobayashi, G. Subramaniam, R. Bittman, and R.E. Pagano. 2006. Caveolar endocytosis and microdomain association of a glycosphingolipid analog is dependent on its sphingosine stereochemistry. J. Biol. Chem. 281:30660-30668.
28. Stang, E., J. Kartenbeck, and R.G. Parton. 1997. Major histocompatibility complex class I molecules mediate association of SV40 with caveolae. Mol. Biol. Cell. 8:47-57.
29. Tagawa, A., A. Mezzacasa, A. Hayer, A. Longatti, L. Pelkmans, and A. Helenius. 2005. Assembly and trafficking of caveolar domains in the cell: caveolae as stable, cargo-triggered, vesicular transporters. J. Cell Biol. 170:769-779.
30. Tsai, B., J.M. Gilbert, T. Stehle, W. Lencer, T.L. Benjamin, and T.A. Rapoport. 2003. Gangliosides are receptors for murine polyoma virus and SV40. EMBO J. 22:4346-4355.
31. Upla, P., V. Marjomaki, P. Kankaanpaa, J. Ivaska, T. Hyypia, F.G. Van Der Goot, and J. Heino. 2004. Clustering induces a lateral redistribution of α2β1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization. Mol. Biol. Cell. 15:625-636.
32. Waheed, A.A., Y. Shimada, H.F. Heijnen, M. Nakamura, M. Inomata, M. Hayashi, S. Iwashita, J.W. Slot, and Y. Ohno-Iwashita. 2001. Selective binding of perfringolysin O derivative to cholesterol-rich membrane microdomains (rafts). Proc. Natl. Acad. Sci. USA. 98:4926-4931.