Non-covalent complexes between bis-β-carbolines and double-stranded DNA: A study by electrospray ionization FT-ICR mass spectrometry (I)

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 9, 2007, Pages 2549-2553

  Dong, Xiaochun ^a   Xu, Ying ^a,b   Afonso, Carlos ^b   Jiang, Weiqun ^a   Laronze, Jean Yves ^c   Wen, Ren ^a   Tabet, Jean Claude ^b  

^a FUDAN UNIVERSITY   (China)

^b Centre National de la Recherche Scientifique   (France)

^c UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

Bis carbolines; DNA; Mass spectrometry; Non covalent interaction

Indexed keywords

ALKALOID DERIVATIVE; ANTINEOPLASTIC AGENT; BIS BETA CARBOLINE DERIVATIVE; CARBOLINE DERIVATIVE; DOUBLE STRANDED DNA; OLIGODEOXYNUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; DNA BINDING; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE;

ALKALOIDS; ANIMALS; BINDING, COMPETITIVE; CARBOLINES; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; CYCLOTRONS; DNA; DRUG DESIGN; MASS SPECTROMETRY; MICE; MODELS, CHEMICAL; MOLECULAR CONFORMATION; SPECTROMETRY, FLUORESCENCE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 33947714244     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.02.010     Document Type: Article

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11. Mass spectra were obtained on a hydrid QqFT/ICR (ApexQe, Brucker) equipped with an ApolloII orthogonal ESI source. Solutions were infused at a rate of 120 μL/h. The image signal was amplified and digitized using 1M data points.
12. UV-vis absorption and fluorescence spectra were measured on Shimadzu UV-260 UV/vis Spectrophotometer and Hitachi Spectrofluorophotometer F-3000, respectively.
13. Single-strands oligodeoxynucleotide were purchased from DNA Technology A/S (Denmark).
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16. a) were derived from the analysis of the relationship between the fluorescence intensity changes and the compound concentrations by Scatchard method.