메뉴 건너뛰기




Volumn 7, Issue 3, 2007, Pages 285-295

Treatment of acute myeloid leukemia in older patients

Author keywords

Acute myeloid leukemia; Cytogenetics; Elderly; Low dose cytabine; Novel agents

Indexed keywords

4 [6 METHOXY 7 [3 (1 PIPERIDINYL)PROPOXY] 4 QUINAZOLINYL] 1 PIPERAZINECARBOXYLIC ACID (4 ISOPROPOXYPHENYL)AMIDE; ANTHRACYCLINE DERIVATIVE; ANTHRAQUINONE; ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; CEP 701; CYTARABINE; CYTOTOXIC AGENT; DAUNORUBICIN; DOXORUBICIN; ETOPOSIDE; GEMTUZUMAB OZOGAMICIN; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYDROXYUREA; IDARUBICIN; INTERFERON; LONAFARNIB; MIDOSTAURIN; MITOXANTRONE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RETINOIC ACID; SUNITINIB; TIOGUANINE; TIPIFARNIB; UNINDEXED DRUG; VALPROIC ACID; VALSPODAR; VORINOSTAT; ZOSUQUIDAR;

EID: 33947677691     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/14737140.7.3.285     Document Type: Review
Times cited : (24)

References (81)
  • 2
    • 33646199707 scopus 로고    scopus 로고
    • Treatment of older patients with acute myeloid leukemia - New agents
    • Burnett AK, Mohite U. Treatment of older patients with acute myeloid leukemia - new agents. Semin. Hematol 43(2), 96-106 (2006).
    • (2006) Semin. Hematol , vol.43 , Issue.2 , pp. 96-106
    • Burnett, A.K.1    Mohite, U.2
  • 3
    • 34249340637 scopus 로고    scopus 로고
    • Chromosome aberrations, gene mutations and expression changes, and prognosis in adult acute myeloid leukemia
    • In: American Society of Hematology, DC, USA
    • Mrozek K, Bloomfield CD. Chromosome aberrations, gene mutations and expression changes, and prognosis in adult acute myeloid leukemia. In: The American Society of Hematology Education Program Book. American Society of Hematology, DC, USA 169-177 (2006).
    • (2006) The American Society of Hematology Education Program Book , pp. 169-177
    • Mrozek, K.1    Bloomfield, C.D.2
  • 4
    • 0031005627 scopus 로고    scopus 로고
    • Acute myeloid leukemia in the elderly: Assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy
    • A Southwest Oncology Group study
    • Leith CP, Kopecky KJ, Godwin J et al. Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group study. Blood 89(9), 3323-3329 (1997).
    • (1997) Blood , vol.89 , Issue.9 , pp. 3323-3329
    • Leith, C.P.1    Kopecky, K.J.2    Godwin, J.3
  • 5
    • 77950836730 scopus 로고    scopus 로고
    • Effects of initial treatment on survival among elderly AML patients: Findings from the SEER-Medicare database
    • Menzin J. Effects of initial treatment on survival among elderly AML patients: findings from the SEER-Medicare database. Blood 108(11), A558 (2006).
    • (2006) Blood , vol.108 , Issue.11
    • Menzin, J.1
  • 6
    • 33745199587 scopus 로고    scopus 로고
    • Fifty years of clinical research by the Leukemia Committee of the Cancer and Leukemia Group B
    • Larson R. Fifty years of clinical research by the Leukemia Committee of the Cancer and Leukemia Group B. Clin. Cancer Res. 12(Suppl. 11), 3556-3563 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , Issue.SUPPL. 11 , pp. 3556-3563
    • Larson, R.1
  • 7
    • 0024458031 scopus 로고
    • On the value of intensive remission-induction chemotherapy in elderly patients of 65+ years with acute myeloid leukemia: A randomized Phase III study of the European Organization for Research and Treatment of Cancer Leukemia Group
    • Lowenberg B, Zittoun R, Kerkhofs H et al. On the value of intensive remission-induction chemotherapy in elderly patients of 65+ years with acute myeloid leukemia: a randomized Phase III study of the European Organization for Research and Treatment of Cancer Leukemia Group. J. Clin. Oncol, 7(9), 1268-1274 (1989).
    • (1989) J. Clin. Oncol, , vol.7 , Issue.9 , pp. 1268-1274
    • Lowenberg, B.1    Zittoun, R.2    Kerkhofs, H.3
  • 8
    • 0021943673 scopus 로고
    • Low-dose cytosine arabinoside treatment for acute nonlymphocytic leukemia in elderly patients
    • Tilly H, Castaigne S, Bordessoule D et al. Low-dose cytosine arabinoside treatment for acute nonlymphocytic leukemia in elderly patients. Cancer 55(8), 1633-1636 (1985).
    • (1985) Cancer , vol.55 , Issue.8 , pp. 1633-1636
    • Tilly, H.1    Castaigne, S.2    Bordessoule, D.3
  • 9
    • 0021791313 scopus 로고
    • Low-dose cytosine arabinoside in the myelodysplastic syndromes and acute myelogenous leukemia
    • Roberts JD, Ershler WB, Tindle BH, Stewart JA. Low-dose cytosine arabinoside in the myelodysplastic syndromes and acute myelogenous leukemia. Cancer 56(5), 1001-1005 (1985).
    • (1985) Cancer , vol.56 , Issue.5 , pp. 1001-1005
    • Roberts, J.D.1    Ershler, W.B.2    Tindle, B.H.3    Stewart, J.A.4
  • 10
    • 0021814287 scopus 로고
    • Treatment of leukemia with low-dose ara-C: A study of 160 cases
    • Degos L, Castaigne S, Tilly H, Sigaux F, Daniel MT. Treatment of leukemia with low-dose ara-C: a study of 160 cases. Semin. Oncol 12(2 Suppl. 3), 196-199 (1985).
    • (1985) Semin. Oncol , vol.12 , Issue.2 SUPPL. 3 , pp. 196-199
    • Degos, L.1    Castaigne, S.2    Tilly, H.3    Sigaux, F.4    Daniel, M.T.5
  • 11
    • 0022873032 scopus 로고
    • A critical appraisal of low-dose cytosine arabinoside in patients with acute non-lymphocytic leukemia and myelodysplastic syndromes
    • Cheson BD, Jasperse DM, Simon R, Friedman MA. A critical appraisal of low-dose cytosine arabinoside in patients with acute non-lymphocytic leukemia and myelodysplastic syndromes. J. Clin. Oncol. 4(12), 1857-1864 (1986).
    • (1986) J. Clin. Oncol. , vol.4 , Issue.12 , pp. 1857-1864
    • Cheson, B.D.1    Jasperse, D.M.2    Simon, R.3    Friedman, M.A.4
  • 12
    • 18044399207 scopus 로고    scopus 로고
    • Low-dose ara-C with or without retinoid in older patients not considered fit for intensive chemotherapy
    • Burnett A. Low-dose ara-C with or without retinoid in older patients not considered fit for intensive chemotherapy. Blood 104, A249 (2004).
    • (2004) Blood , vol.104
    • Burnett, A.1
  • 13
    • 0037158110 scopus 로고    scopus 로고
    • The outcomes and costs of acute myeloid leukemia among the elderly
    • Menzin J, Lang K, Earle CC, Kerney D, Mallick R. The outcomes and costs of acute myeloid leukemia among the elderly. Arch. Intern. Med. 162(14), 1597-1603 (2002).
    • (2002) Arch. Intern. Med. , vol.162 , Issue.14 , pp. 1597-1603
    • Menzin, J.1    Lang, K.2    Earle, C.C.3    Kerney, D.4    Mallick, R.5
  • 14
    • 0033619959 scopus 로고    scopus 로고
    • Underrepresentation of patients 65 years of age or older in cancer-treatment trials
    • Hutchins LF, Unger JM, Crowley JJ, Coltman CA Jr, Albain KS. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N. Engl. J. Med. 341(27), 2061-2067 (1999).
    • (1999) N. Engl. J. Med. , vol.341 , Issue.27 , pp. 2061-2067
    • Hutchins, L.F.1    Unger, J.M.2    Crowley, J.J.3    Coltman Jr., C.A.4    Albain, K.S.5
  • 15
    • 33646015039 scopus 로고    scopus 로고
    • General approach to, and perspectives on clinical research in, older patients with newly diagnosed acute myeloid leukemia
    • Esrey EH. General approach to, and perspectives on clinical research in, older patients with newly diagnosed acute myeloid leukemia. Semin. Hematol, 43(2), 89-95 (2006).
    • (2006) Semin. Hematol, , vol.43 , Issue.2 , pp. 89-95
    • Esrey, E.H.1
  • 16
    • 0035469883 scopus 로고    scopus 로고
    • The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): Analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial
    • Grimwade D, Walker H, Harrison G et al. The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial. Blood 98(5), 1312-1320 (2001).
    • (2001) Blood , vol.98 , Issue.5 , pp. 1312-1320
    • Grimwade, D.1    Walker, H.2    Harrison, G.3
  • 17
    • 0030765385 scopus 로고    scopus 로고
    • Effect of diagnosis (refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, or acute myeloid leukemia [AML]) on outcome of AML-type chemotherapy
    • Estey E, Thall P, Beran M et al. Effect of diagnosis (refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, or acute myeloid leukemia [AML]) on outcome of AML-type chemotherapy. Blood 90(8), 2969-2977 (1997).
    • (1997) Blood , vol.90 , Issue.8 , pp. 2969-2977
    • Estey, E.1    Thall, P.2    Beran, M.3
  • 18
    • 33644521267 scopus 로고    scopus 로고
    • Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome: Predictive prognostic models for outcome
    • Kantarjian H, O'Brien S, Cortes J et al. Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome: predictive prognostic models for outcome. Cancer 106(5), 1090-1098 (2006).
    • (2006) Cancer , vol.106 , Issue.5 , pp. 1090-1098
    • Kantarjian, H.1    O'Brien, S.2    Cortes, J.3
  • 19
    • 0032878617 scopus 로고    scopus 로고
    • Has the prognosis of adult patients with acute myeloid leukemia improved over years? A single institution experience of 784 consecutive patients over a 16-year period
    • Baudard M, Beauchamp-Nicoud A, Delmer A et al. Has the prognosis of adult patients with acute myeloid leukemia improved over years? A single institution experience of 784 consecutive patients over a 16-year period. Leukemia 13(10), 1481-1490 (1999).
    • (1999) Leukemia , vol.13 , Issue.10 , pp. 1481-1490
    • Baudard, M.1    Beauchamp-Nicoud, A.2    Delmer, A.3
  • 20
    • 0028590096 scopus 로고
    • Prognostic factors in elderly patients with acute myeloid leukaemia
    • Johnson PR, Yin JA. Prognostic factors in elderly patients with acute myeloid leukaemia. Leuk. Lymphoma 16(1-2), 51-56 (1994).
    • (1994) Leuk. Lymphoma , vol.16 , Issue.1-2 , pp. 51-56
    • Johnson, P.R.1    Yin, J.A.2
  • 21
    • 33751172127 scopus 로고    scopus 로고
    • Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: Results from AMLSG trial AML HD98-B
    • Frohling S, Schlenk RF, Kayser S et al. Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B. Blood 108(10), 3280-3288 (2006).
    • (2006) Blood , vol.108 , Issue.10 , pp. 3280-3288
    • Frohling, S.1    Schlenk, R.F.2    Kayser, S.3
  • 22
    • 18044366547 scopus 로고    scopus 로고
    • Disease biology rather than age is the most important determinant of survival of patients > or = 60 years with acute myeloid leukemia treated with uniform intensive therapy
    • Gupta V, Chun K, Yi QL et al. Disease biology rather than age is the most important determinant of survival of patients > or = 60 years with acute myeloid leukemia treated with uniform intensive therapy. Cancer 103(10), 2082-2090 (2005).
    • (2005) Cancer , vol.103 , Issue.10 , pp. 2082-2090
    • Gupta, V.1    Chun, K.2    Yi, Q.L.3
  • 23
    • 24944464648 scopus 로고    scopus 로고
    • Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): A Cancer and Leukemia Group B study
    • Marcucci G, Mrozek K, Ruppert AS et al. Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): a Cancer and Leukemia Group B study. J. Clin. Oncol. 23(24), 5705-5717 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.24 , pp. 5705-5717
    • Marcucci, G.1    Mrozek, K.2    Ruppert, A.S.3
  • 24
    • 4644234164 scopus 로고    scopus 로고
    • The influence of age on prognosis of de novo acute myeloid leukemia differs according to cytogenctic subgroups
    • Schoch C, Kern W, Schnittger S et al. The influence of age on prognosis of de novo acute myeloid leukemia differs according to cytogenctic subgroups. Haematologica 89(9), 1082-1090 (2004).
    • (2004) Haematologica , vol.89 , Issue.9 , pp. 1082-1090
    • Schoch, C.1    Kern, W.2    Schnittger, S.3
  • 25
    • 33646404606 scopus 로고    scopus 로고
    • Age and acute myeloid leukemia
    • Appelbaum FR, Gundacker H, Head DR et al. Age and acute myeloid leukemia. Blood 107(9), 3481-3485 (2006).
    • (2006) Blood , vol.107 , Issue.9 , pp. 3481-3485
    • Appelbaum, F.R.1    Gundacker, H.2    Head, D.R.3
  • 26
    • 33846433493 scopus 로고    scopus 로고
    • The haematopoietic cell transplantation comorbidity index score is predictive of early death and survival in patients over 60 years of age receiving induction therapy for acute myeloid leukaemia
    • (Epub ahead of print)
    • Giles FJ, Borthakur G, Ravandi F et al. The haematopoietic cell transplantation comorbidity index score is predictive of early death and survival in patients over 60 years of age receiving induction therapy for acute myeloid leukaemia. Br. J Haematol. (2007) (Epub ahead of print).
    • (2007) Br. J Haematol.
    • Giles, F.J.1    Borthakur, G.2    Ravandi, F.3
  • 27
    • 23944440464 scopus 로고    scopus 로고
    • Hematopoietic cell transplantation (HCT)-specific comorbidity index: A new tool for risk assessment before allogeneic HCT
    • Sorror ML, Maris MB, Storb R et al. Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Blood 106(8), 2912-2919 (2005).
    • (2005) Blood , vol.106 , Issue.8 , pp. 2912-2919
    • Sorror, M.L.1    Maris, M.B.2    Storb, R.3
  • 28
    • 0035760302 scopus 로고    scopus 로고
    • Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: A Southwest Oncology Group study
    • List AF, Kopecky KJ, Willman CL et al. Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study. Blood 98(12), 3212-3220 (2001).
    • (2001) Blood , vol.98 , Issue.12 , pp. 3212-3220
    • List, A.F.1    Kopecky, K.J.2    Willman, C.L.3
  • 29
    • 27144508406 scopus 로고    scopus 로고
    • The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis
    • van der Holt B, Lowenberg B, Burnett AK et al. The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis. Blood 106(8), 2646-2654 (2005).
    • (2005) Blood , vol.106 , Issue.8 , pp. 2646-2654
    • van der Holt, B.1    Lowenberg, B.2    Burnett, A.K.3
  • 30
    • 0037103189 scopus 로고    scopus 로고
    • Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B study 9720
    • Baer MR, George SL, Dodge RK et al. Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B study 9720. Blood 100(4), 1224-1232 (2002).
    • (2002) Blood , vol.100 , Issue.4 , pp. 1224-1232
    • Baer, M.R.1    George, S.L.2    Dodge, R.K.3
  • 31
    • 33947694709 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, double blind trial of the MDR modulator, zosuquidar, during conventional induction and post-remission therapy for pts > 60 years of age with newly diagnosed acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (HR-MDS): ECOG 3999
    • Cripe LD, Li X, Litzow M et al. A randomized, placebo-controlled, double blind trial of the MDR modulator, zosuquidar, during conventional induction and post-remission therapy for pts > 60 years of age with newly diagnosed acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (HR-MDS): ECOG 3999. Blood 108, A129 (2006).
    • (2006) Blood , vol.108
    • Cripe, L.D.1    Li, X.2    Litzow, M.3
  • 32
    • 0036733277 scopus 로고    scopus 로고
    • Antibody-targeted chemotherapy of older patients with acute myeloid leukemia in first relapse using Mylotarg (gemtuzumab ozogamicin)
    • Larson RA, Boogaerts M, Esrey E et al. Antibody-targeted chemotherapy of older patients with acute myeloid leukemia in first relapse using Mylotarg (gemtuzumab ozogamicin). Leukemia 16(9), 1627-1636 (2002).
    • (2002) Leukemia , vol.16 , Issue.9 , pp. 1627-1636
    • Larson, R.A.1    Boogaerts, M.2    Esrey, E.3
  • 33
    • 0035397980 scopus 로고    scopus 로고
    • Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse
    • Sievers EL, Larson RA, Stadtmauer EA et al. Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse. J Clin. Oncol. 19(13), 3244-3254 (2001).
    • (2001) J Clin. Oncol. , vol.19 , Issue.13 , pp. 3244-3254
    • Sievers, E.L.1    Larson, R.A.2    Stadtmauer, E.A.3
  • 34
    • 0036784822 scopus 로고    scopus 로고
    • Efficacy and safety of gemtuzumab ozogamicin in patients with poor-prognosis acute myeloid leukemia
    • Roboz GJ, Knovich MA, Bayer RL et al. Efficacy and safety of gemtuzumab ozogamicin in patients with poor-prognosis acute myeloid leukemia. Leuk. Lymphoma 43(10), 1951-1955 (2002).
    • (2002) Leuk. Lymphoma , vol.43 , Issue.10 , pp. 1951-1955
    • Roboz, G.J.1    Knovich, M.A.2    Bayer, R.L.3
  • 35
    • 0037097707 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin with or without interleukin 11 in patients 65 years of age or older with untreated acute myeloid leukemia and high-risk myelodysplastic syndrome: Comparison with idarubicin plus continuous-infusion, high-dose cytosine arabinoside
    • Estey EH, Thall PF, Giles FJ et al. Gemtuzumab ozogamicin with or without interleukin 11 in patients 65 years of age or older with untreated acute myeloid leukemia and high-risk myelodysplastic syndrome: comparison with idarubicin plus continuous-infusion, high-dose cytosine arabinoside. Blood 99(12), 4343-4349(2002).
    • (2002) Blood , vol.99 , Issue.12 , pp. 4343-4349
    • Estey, E.H.1    Thall, P.F.2    Giles, F.J.3
  • 36
    • 27144464151 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin (Mylotarg) as single-agent treatment for frail patients 61 years of age and older with acute myeloid leukemia: Final results of AML-15B, a Phase 2 study of the European Organisation for Research and Treatment of Cancer and Gruppo Italiano Malattie Ematologiche dell'Adulto Leukemia Groups
    • Amadori S, Suciu S, Stasi R et al. Gemtuzumab ozogamicin (Mylotarg) as single-agent treatment for frail patients 61 years of age and older with acute myeloid leukemia: final results of AML-15B, a Phase 2 study of the European Organisation for Research and Treatment of Cancer and Gruppo Italiano Malattie Ematologiche dell'Adulto Leukemia Groups. Leukemia 19(10), 1768-1773(2005).
    • (2005) Leukemia , vol.19 , Issue.10 , pp. 1768-1773
    • Amadori, S.1    Suciu, S.2    Stasi, R.3
  • 37
    • 10744230708 scopus 로고    scopus 로고
    • A feasibility study of simultaneous administration of gemtuzumab ozogamicin with intensive chemotherapy in induction and consolidation in younger patients with acute myeloid leukemia
    • Kell WJ, Burnett AK, Chopra R et al. A feasibility study of simultaneous administration of gemtuzumab ozogamicin with intensive chemotherapy in induction and consolidation in younger patients with acute myeloid leukemia. Blood 102(13), 4277-4283 (2003).
    • (2003) Blood , vol.102 , Issue.13 , pp. 4277-4283
    • Kell, W.J.1    Burnett, A.K.2    Chopra, R.3
  • 38
    • 33947659491 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin is an acceptable alternative to anthracyclines in combination with standard dose infusional cytarabine as induction therapy for elderly patients with acute myeloid leukemia (AML)
    • Roboz GJ, Ritchie EK, Schuster MW er al. Gemtuzumab ozogamicin is an acceptable alternative to anthracyclines in combination with standard dose infusional cytarabine as induction therapy for elderly patients with acute myeloid leukemia (AML). Blood 106, A221 (2005).
    • (2005) Blood , vol.106
    • Roboz, G.J.1    Ritchie, E.K.2    Schuster, M.W.3
  • 39
    • 0345689346 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors in hematologic malignancies: New horizons in therapy
    • Lancet JE, Karp JE. Farnesyltransferase inhibitors in hematologic malignancies: new horizons in therapy. Blood 102(12), 3880-3889 (2003).
    • (2003) Blood , vol.102 , Issue.12 , pp. 3880-3889
    • Lancet, J.E.1    Karp, J.E.2
  • 40
    • 33847001315 scopus 로고    scopus 로고
    • A Phase II study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia
    • Lancet JE, Gojo I, Gotlib J et al. A Phase II study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia. Blood 109(4), 1387-1394 (2007).
    • (2007) Blood , vol.109 , Issue.4 , pp. 1387-1394
    • Lancet, J.E.1    Gojo, I.2    Gotlib, J.3
  • 41
    • 34147147730 scopus 로고    scopus 로고
    • FLT3 mutations: Biology and treatment
    • In: American Society of Hematology, DC, USA
    • Small D. FLT3 mutations: biology and treatment. In: The American Society of Hematology Education Program Book. American Society of Hematology, DC, USA 178-184 (2006).
    • (2006) The American Society of Hematology Education Program Book , pp. 178-184
    • Small, D.1
  • 42
    • 0034040255 scopus 로고    scopus 로고
    • Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene
    • Rombouts WJ, Blokland I, Lowenberg B, Ploemacher RE. Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene. Leukemia 14(4), 675-683 (2000).
    • (2000) Leukemia , vol.14 , Issue.4 , pp. 675-683
    • Rombouts, W.J.1    Blokland, I.2    Lowenberg, B.3    Ploemacher, R.E.4
  • 43
    • 1842420032 scopus 로고    scopus 로고
    • Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute mycloid leukemia
    • Smith BD, Levis M, Beran M et al. Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute mycloid leukemia. Blood 103(10), 3669-3676 (2004).
    • (2004) Blood , vol.103 , Issue.10 , pp. 3669-3676
    • Smith, B.D.1    Levis, M.2    Beran, M.3
  • 44
    • 19944427559 scopus 로고    scopus 로고
    • Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412
    • Stone RM, DeAngelo DJ, Klimek V et al. Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood 105 (1), 54-60 (2005).
    • (2005) Blood , vol.105 , Issue.1 , pp. 54-60
    • Stone, R.M.1    DeAngelo, D.J.2    Klimek, V.3
  • 45
    • 19944431093 scopus 로고    scopus 로고
    • A Phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease
    • Fiedler W, Serve H, Dohner H et al. A Phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease. Blood 105 (3), 986-993 (2005).
    • (2005) Blood , vol.105 , Issue.3 , pp. 986-993
    • Fiedler, W.1    Serve, H.2    Dohner, H.3
  • 46
    • 33751177110 scopus 로고    scopus 로고
    • The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: The induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases
    • Knapper S, Mills KI, Gilkes AF et al. The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases. Blood 108(10), 3494-3503 (2006).
    • (2006) Blood , vol.108 , Issue.10 , pp. 3494-3503
    • Knapper, S.1    Mills, K.I.2    Gilkes, A.F.3
  • 47
    • 33751173636 scopus 로고    scopus 로고
    • A Phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy
    • Knapper S, Burnett AK, Littlewood T et al. A Phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. Blood 108(10), 3262-3270 (2006).
    • (2006) Blood , vol.108 , Issue.10 , pp. 3262-3270
    • Knapper, S.1    Burnett, A.K.2    Littlewood, T.3
  • 48
    • 2442424121 scopus 로고    scopus 로고
    • A Phase I and pharmacokinetic study of VNP40101M, a novel sulfonylhydrazine alkylating agent, in patients with refractory leukemia
    • Giles F, Thomas D, Garcia-Manero G et al. A Phase I and pharmacokinetic study of VNP40101M, a novel sulfonylhydrazine alkylating agent, in patients with refractory leukemia. Clin. Cancer Res. 10(9), 2908-2917 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , Issue.9 , pp. 2908-2917
    • Giles, F.1    Thomas, D.2    Garcia-Manero, G.3
  • 49
    • 33750022018 scopus 로고    scopus 로고
    • A Phase II study of cloretazine (VNP40101M), a novel sulfony1hydrazine alkylating agent, in patients with very high risk relapsed acute myeloid leukemia
    • Giles F, Verstovsek S, Faderl S et al. A Phase II study of cloretazine (VNP40101M), a novel sulfony1hydrazine alkylating agent, in patients with very high risk relapsed acute myeloid leukemia. Leuk. Res. 30(12), 1591-1595 (2006).
    • (2006) Leuk. Res. , vol.30 , Issue.12 , pp. 1591-1595
    • Giles, F.1    Verstovsek, S.2    Faderl, S.3
  • 50
    • 33644910164 scopus 로고    scopus 로고
    • Cloretazine for the treatment of acute myeloid leukemia
    • Vey N, Giles F. Cloretazine for the treatment of acute myeloid leukemia. Exp. Rev. Anticancer Ther. 6(3), 321-328 (2006).
    • (2006) Exp. Rev. Anticancer Ther. , vol.6 , Issue.3 , pp. 321-328
    • Vey, N.1    Giles, F.2
  • 51
    • 33847044949 scopus 로고    scopus 로고
    • A Phase I study of Cloretazine® and temozolomide in patients with hematologic malignancies
    • Rizzieri DA, Tse W, Khan KD et al. A Phase I study of Cloretazine® and temozolomide in patients with hematologic malignancies. Blood 108, A557 (2006).
    • (2006) Blood , vol.108
    • Rizzieri, D.A.1    Tse, W.2    Khan, K.D.3
  • 52
    • 33846413076 scopus 로고    scopus 로고
    • Cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients age 60 years or older with previously untreated acute myeloid leukemia
    • Giles F, Rizzieri D, Karp J et al. Cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients age 60 years or older with previously untreated acute myeloid leukemia. J Clin. Oncol. 25(1), 25-31 (2007).
    • (2007) J Clin. Oncol. , vol.25 , Issue.1 , pp. 25-31
    • Giles, F.1    Rizzieri, D.2    Karp, J.3
  • 53
    • 0141482004 scopus 로고    scopus 로고
    • Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia
    • Kantarjian H, Gandhi V, Cortes J et al. Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia. Blood 102(7), 2379-2386 (2003).
    • (2003) Blood , vol.102 , Issue.7 , pp. 2379-2386
    • Kantarjian, H.1    Gandhi, V.2    Cortes, J.3
  • 54
    • 34249821127 scopus 로고    scopus 로고
    • A Phase II study (Biov-121) of clofarabine monotherapy first line in patients aged 65 years or older with acute myeloid leukemia for whom standard intensive chemotherapy is not considered suitable
    • Burnett AK, Baccarani M, Johnson P et al. A Phase II study (Biov-121) of clofarabine monotherapy first line in patients aged 65 years or older with acute myeloid leukemia for whom standard intensive chemotherapy is not considered suitable. Blood A130 (2006).
    • (2006) Blood , vol.A130
    • Burnett, A.K.1    Baccarani, M.2    Johnson, P.3
  • 55
    • 33745586575 scopus 로고    scopus 로고
    • Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) inpatients 50 years of age or older
    • Faderl S, Verstovsek S, Cortes J et al. Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) inpatients 50 years of age or older. Blood 108(1), 45-51 (2006).
    • (2006) Blood , vol.108 , Issue.1 , pp. 45-51
    • Faderl, S.1    Verstovsek, S.2    Cortes, J.3
  • 56
    • 33947644861 scopus 로고    scopus 로고
    • Clofarabine and clofarabine plus low-dose cytarabine (ara-C) as induction therapy fbr patients (pts) ≥ 60 years with newly diagnosed acute myeloid leukemia (AML)
    • Faded S, Ravandi F, Ferrajoli A et al. Clofarabine and clofarabine plus low-dose cytarabine (ara-C) as induction therapy fbr patients (pts) ≥ 60 years with newly diagnosed acute myeloid leukemia (AML). Blood 106, A786 (2005).
    • (2005) Blood , vol.106
    • Faded, S.1    Ravandi, F.2    Ferrajoli, A.3
  • 57
    • 33744966168 scopus 로고    scopus 로고
    • Arsenic trioxide in patients with myclodysplastic syndromes: A Phase II multicenter study
    • Vey N, Bosly A, Guerci A et at Arsenic trioxide in patients with myclodysplastic syndromes: a Phase II multicenter study. J Clin. Oncol. 24(16), 2465-2471 (2006).
    • (2006) J Clin. Oncol. , vol.24 , Issue.16 , pp. 2465-2471
    • Vey, N.1    Bosly, A.2    Guerci, A.3
  • 58
    • 33745002275 scopus 로고    scopus 로고
    • Phase II multicenter study of arsenic trioxide in patients with myelodysplastic syndromes
    • Schiller GJ, Slack J, Hainsworth JD et al. Phase II multicenter study of arsenic trioxide in patients with myelodysplastic syndromes. J. Clin. Oncol. 24(16), 2456-2464 (2006).
    • (2006) J. Clin. Oncol. , vol.24 , Issue.16 , pp. 2456-2464
    • Schiller, G.J.1    Slack, J.2    Hainsworth, J.D.3
  • 59
    • 3242689062 scopus 로고    scopus 로고
    • Phase II trial of arsenic trioxide in relapsed and refractory acute myeloid leukemia, secondary leukemia and/or newly diagnosed patients at least 65 years old
    • Parmar S, Rundhaugen LM, Boehlke L et al. Phase II trial of arsenic trioxide in relapsed and refractory acute myeloid leukemia, secondary leukemia and/or newly diagnosed patients at least 65 years old. Leuk. Res. 28(9), 909-919 (2004).
    • (2004) Leuk. Res. , vol.28 , Issue.9 , pp. 909-919
    • Parmar, S.1    Rundhaugen, L.M.2    Boehlke, L.3
  • 60
    • 33947673935 scopus 로고    scopus 로고
    • Treatment of non-APL acute myelogenous leukemia with intravenous arsenic trioxide plus ascorbic acid
    • Douer D, Watkins K, Louie R et al. Treatment of non-APL acute myelogenous leukemia with intravenous arsenic trioxide plus ascorbic acid. Blood 108, A554 (2006).
    • (2006) Blood , vol.108
    • Douer, D.1    Watkins, K.2    Louie, R.3
  • 61
    • 38849166255 scopus 로고    scopus 로고
    • Arsenic trioxide (ATO) is safe and effective in combination with low-dose Ara-C (LDAC) for the treatment of IPSS-2 myelodysplastic syndrome (MDS) and poor-prognosis acute myeloid leukemia (AML) in elderly patients
    • Roboz GJ, Ritchie EK, Allen-Bard S et al. Arsenic trioxide (ATO) is safe and effective in combination with low-dose Ara-C (LDAC) for the treatment of IPSS-2 myelodysplastic syndrome (MDS) and poor-prognosis acute myeloid leukemia (AML) in elderly patients. Blood 106, A528 (2005).
    • (2005) Blood , vol.106
    • Roboz, G.J.1    Ritchie, E.K.2    Allen-Bard, S.3
  • 62
    • 33646196925 scopus 로고    scopus 로고
    • Allogeneic transplantation for the elderly patient with acute myelogenous leukemia or myelodysplastic syndrome
    • de Lima M, Giralt S. Allogeneic transplantation for the elderly patient with acute myelogenous leukemia or myelodysplastic syndrome. Semin. Hematol. 43(2), 107-117 (2006).
    • (2006) Semin. Hematol. , vol.43 , Issue.2 , pp. 107-117
    • de Lima, M.1    Giralt, S.2
  • 63
    • 0141958295 scopus 로고    scopus 로고
    • Reduced-intensity conditioning for unrelated donor hematopoietic stem cell transplantation as treatment for myeloid malignancies in patients older than 55 years
    • Wong R, Giralt SA, Martin T et al. Reduced-intensity conditioning for unrelated donor hematopoietic stem cell transplantation as treatment for myeloid malignancies in patients older than 55 years. Blood 102(8), 3052-3059 (2003).
    • (2003) Blood , vol.102 , Issue.8 , pp. 3052-3059
    • Wong, R.1    Giralt, S.A.2    Martin, T.3
  • 64
    • 19944429335 scopus 로고    scopus 로고
    • Hematopoietic stem-cell transplantation from unrelated donors in elderly patients (age >55 years) with hematologic malignancies: Older age is no longer a contraindication when using reduced intensity conditioning
    • Shimoni A, Kroger N, Zabelina T et al. Hematopoietic stem-cell transplantation from unrelated donors in elderly patients (age >55 years) with hematologic malignancies: older age is no longer a contraindication when using reduced intensity conditioning. Leukemia 19(1), 7-12 (2005).
    • (2005) Leukemia , vol.19 , Issue.1 , pp. 7-12
    • Shimoni, A.1    Kroger, N.2    Zabelina, T.3
  • 65
    • 33644833398 scopus 로고    scopus 로고
    • Treatment for acute myelogenous leukemia by low-dose, total-body, irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors
    • Hegenbart U, Niederwieser D, Sandmaier BM et al. Treatment for acute myelogenous leukemia by low-dose, total-body, irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors. J CLin. Oncol. 24(3), 444-453 (2006).
    • (2006) J CLin. Oncol. , vol.24 , Issue.3 , pp. 444-453
    • Hegenbart, U.1    Niederwieser, D.2    Sandmaier, B.M.3
  • 66
    • 32844473063 scopus 로고    scopus 로고
    • Reduced-toxicity conditioning with treosulfan, fludarabine and ATG as preparative regimen for allogeneic stem cell transplantation (alloSCT) in elderly patients with secondary acute myeloid leukemia (sAML) or myelodysplastic syndrome (MDS)
    • Kroger N, Shimoni A, Zabetina. T et al. Reduced-toxicity conditioning with treosulfan, fludarabine and ATG as preparative regimen for allogeneic stem cell transplantation (alloSCT) in elderly patients with secondary acute myeloid leukemia (sAML) or myelodysplastic syndrome (MDS). Bone Marrow Transplant. 37(4), 339-344 (2006).
    • (2006) Bone Marrow Transplant. , vol.37 , Issue.4 , pp. 339-344
    • Kroger, N.1    Shimoni, A.2    Zabetina, T.3
  • 67
    • 24944582579 scopus 로고    scopus 로고
    • Fludarabine, melphalan, and alemtuzumab conditioning in adults with standard-risk advanced acute myeloid leukemia and myelodysplastic syndrome
    • van Besien K, Ariz A, Smith S et al. Fludarabine, melphalan, and alemtuzumab conditioning in adults with standard-risk advanced acute myeloid leukemia and myelodysplastic syndrome. J Clin. Oncol. 23(24), 5728-5738 (2005).
    • (2005) J Clin. Oncol. , vol.23 , Issue.24 , pp. 5728-5738
    • van Besien, K.1    Ariz, A.2    Smith, S.3
  • 68
    • 33846924515 scopus 로고    scopus 로고
    • Prospective feasibility analysis of reduced intensity conditioning regimens (RIC) for hematopoetic stem cell transplantation (HSCT) in elderly patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS)
    • Estey E, de Lima M, Tibes R et al. Prospective feasibility analysis of reduced intensity conditioning regimens (RIC) for hematopoetic stem cell transplantation (HSCT) in elderly patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS). Blood 109(4), 1395-1400 (2007)
    • (2007) Blood , vol.109 , Issue.4 , pp. 1395-1400
    • Estey, E.1    de Lima, M.2    Tibes, R.3
  • 69
    • 33646491445 scopus 로고    scopus 로고
    • Reduced intensity conditioning allows for up-front allogeneic hematopoietic stem cell transplantation after cytoreductive induction therapy in newly-diagnosed high-risk acute myeloid leukemia
    • Platzbecker U, Thiede C, Fussel M et al. Reduced intensity conditioning allows for up-front allogeneic hematopoietic stem cell transplantation after cytoreductive induction therapy in newly-diagnosed high-risk acute myeloid leukemia. Leukemia 20(4), 707-714 (2006).
    • (2006) Leukemia , vol.20 , Issue.4 , pp. 707-714
    • Platzbecker, U.1    Thiede, C.2    Fussel, M.3
  • 70
    • 33947700936 scopus 로고    scopus 로고
    • Effect of failure to respond to targeted therapy on response ta cytotoxic therapy in pts age ≥ 60 with newly-diagnosed AML
    • Estey EH, Garcia-Manero G, Giles F, Kantarjian HM. Effect of failure to respond to targeted therapy on response ta cytotoxic therapy in pts age ≥ 60 with newly-diagnosed AML. Blood A556 (2006).
    • (2006) Blood
    • Estey, E.H.1    Garcia-Manero, G.2    Giles, F.3    Kantarjian, H.M.4
  • 72
    • 8844221254 scopus 로고    scopus 로고
    • Clinical trials in AML of the elderly: Should we change our methodology?
    • Estey E. Clinical trials in AML of the elderly: should we change our methodology? Leukemia 18(11), 1772-1774 (2004).
    • (2004) Leukemia , vol.18 , Issue.11 , pp. 1772-1774
    • Estey, E.1
  • 73
    • 0027941369 scopus 로고
    • Intensive postremission chemotherapy in adults with acute myeloid leukemia
    • Cancer and Leukemia Group B
    • Mayer RJ, Davis RB, Schiffer CA et al. Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and Leukemia Group B. N. Engl. J. Med. 331(14), 896-903 (1994).
    • (1994) N. Engl. J. Med. , vol.331 , Issue.14 , pp. 896-903
    • Mayer, R.J.1    Davis, R.B.2    Schiffer, C.A.3
  • 74
    • 0029033064 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor after initial chemotherapy for elderly patients with primary acute myelogenous leukemia
    • Cancer and Leukemia Group B
    • Stone R. Granulocyte-macrophage colony-stimulating factor after initial chemotherapy for elderly patients with primary acute myelogenous leukemia. Cancer and Leukemia Group B. N. Engl J. Med. 332, 1671-1677 (1995).
    • (1995) N. Engl J. Med. , vol.332 , pp. 1671-1677
    • Stone, R.1
  • 75
    • 0029015209 scopus 로고
    • A randomized placebo-controlled Phase III study of granulocyte-macrophage colony-stimulating factor in adult patients (> 55 to 70 years of age) with acute myelogenous leukemia: A study of the Eastern Cooperative Oncology Group (E1490)
    • Rowe JM, Andersen JW, Mazza JJ et al. A randomized placebo-controlled Phase III study of granulocyte-macrophage colony-stimulating factor in adult patients (> 55 to 70 years of age) with acute myelogenous leukemia: a study of the Eastern Cooperative Oncology Group (E1490). Blood 86(2), 457-462 (1995).
    • (1995) Blood , vol.86 , Issue.2 , pp. 457-462
    • Rowe, J.M.1    Andersen, J.W.2    Mazza, J.J.3
  • 76
    • 0032525248 scopus 로고    scopus 로고
    • A double-blind placebo-controlled trial of granulocyte colony-stimulating factor in elderly patients with previously untreated acute myeloid leukemia: A Southwest Oncology Group study
    • (9031)
    • Godwin JE, Kopecky KJ, Head DR et al. A double-blind placebo-controlled trial of granulocyte colony-stimulating factor in elderly patients with previously untreated acute myeloid leukemia: a Southwest Oncology Group study (9031). Blood 91 (10), 3607-3615 (1998).
    • (1998) Blood , vol.91 , Issue.10 , pp. 3607-3615
    • Godwin, J.E.1    Kopecky, K.J.2    Head, D.R.3
  • 77
    • 0343045296 scopus 로고    scopus 로고
    • Mitoxantrone versus daunorubicin in induction-consolidation chemotherapy - The value of low-dose cytarabine for maintenance of remission, and an assessment of prognostic factors in acute myeloid leukemia in the elderly: Final report
    • European Organization for the Research and Treatment of Cancer and the Dutch-Belgian Hemato-Oncology Cooperative HOVON Group
    • Lowenberg B, Suciu S, Archimbaud E et al. Mitoxantrone versus daunorubicin in induction-consolidation chemotherapy - the value of low-dose cytarabine for maintenance of remission, and an assessment of prognostic factors in acute myeloid leukemia in the elderly: final report. European Organization for the Research and Treatment of Cancer and the Dutch-Belgian Hemato-Oncology Cooperative HOVON Group. J Clin. Oncol. 16(3), 872-881 (1998).
    • (1998) J Clin. Oncol. , vol.16 , Issue.3 , pp. 872-881
    • Lowenberg, B.1    Suciu, S.2    Archimbaud, E.3
  • 78
    • 0035469856 scopus 로고    scopus 로고
    • Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: The results ofthe United Kingdom Medical Research Council AML11 trial
    • Goldstone AH, Burnett AK, Wheatley K et al. Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: the results ofthe United Kingdom Medical Research Council AML11 trial. Blood 98(5), 1302-1311 (2001).
    • (2001) Blood , vol.98 , Issue.5 , pp. 1302-1311
    • Goldstone, A.H.1    Burnett, A.K.2    Wheatley, K.3
  • 79
    • 0036892524 scopus 로고    scopus 로고
    • Outcome after induction chemotherapy for older patients with acute myeloid leukemia is not improved with mitoxantrone and etoposide compared to cytarabine and daunorubicin: A Southwest Oncology Group study
    • Anderson JE, Kopecky KJ, Willman CL et al. Outcome after induction chemotherapy for older patients with acute myeloid leukemia is not improved with mitoxantrone and etoposide compared to cytarabine and daunorubicin: a Southwest Oncology Group study. Blood 100(12), 3869-3876 (2002).
    • (2002) Blood , vol.100 , Issue.12 , pp. 3869-3876
    • Anderson, J.E.1    Kopecky, K.J.2    Willman, C.L.3
  • 80
    • 1542753653 scopus 로고    scopus 로고
    • 6-Thioguanine, cytarabine, and daunorubicin (TAD) and high-dose cytarabine and mitoxantrone (HAM) for induction, TAD for consolidation, and either prolonged maintenance by reduced monthly TAD or TAD-HAM-TAD and one course of intensive consolidation by sequential HAM in adult patients at all ages with de novo acute myeloid leukemia (AML): A randomized trial of the German AML Cooperative Group
    • Buchner T, Hiddemann W, Berdel WE et al. 6-Thioguanine, cytarabine, and daunorubicin (TAD) and high-dose cytarabine and mitoxantrone (HAM) for induction, TAD for consolidation, and either prolonged maintenance by reduced monthly TAD or TAD-HAM-TAD and one course of intensive consolidation by sequential HAM in adult patients at all ages with de novo acute myeloid leukemia (AML): a randomized trial of the German AML Cooperative Group. J. Clin. Oncol. 21(24), 4496-4504 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , Issue.24 , pp. 4496-4504
    • Buchner, T.1    Hiddemann, W.2    Berdel, W.E.3
  • 81
    • 9144238671 scopus 로고    scopus 로고
    • A Phase 3 study of three induction regimens and of priming with GM-CSF in older adults with acute myeloid leukemia: A trial by the Eastern Cooperative Oncology Group
    • Rowe JM, Neuberg D, Friedenberg W et al. A Phase 3 study of three induction regimens and of priming with GM-CSF in older adults with acute myeloid leukemia: a trial by the Eastern Cooperative Oncology Group. Blood 103(2), 479-485 (2004).
    • (2004) Blood , vol.103 , Issue.2 , pp. 479-485
    • Rowe, J.M.1    Neuberg, D.2    Friedenberg, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.