Determination of duloxetine in human plasma via LC/MS and subsequent application to a pharmacokinetic study in healthy Chinese volunteers

Clinica Chimica Acta

Volumn 380, Issue 1-2, 2007, Pages 100-105

  Ma, Ning ^a,b   Zhang, Bi Kui ^a   Li, Huan De ^a   Chen, Ben Mei ^c   Xu, Ping ^a   Wang, Feng ^a   Zhu, Rong Hua ^a   Feng, Sheng ^a   Xiang, Da Xiong ^a   Zhu, Yun Gui ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Duloxetine; Flupentixol dihydrochloride; Liquid chromatography mass spectrometry; Pharmacokinetics

Indexed keywords

DULOXETINE; FLUPENTIXOL;

ADULT; ARTICLE; CHINESE; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG DETERMINATION; DRUG DOSE COMPARISON; DRUG MEGADOSE; ENTERIC COATED TABLET; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; LOW DRUG DOSE; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ADMINISTRATION, ORAL; ADRENERGIC UPTAKE INHIBITORS; ADULT; CHINA; CHROMATOGRAPHY, LIQUID; FEMALE; HUMANS; MALE; MASS SPECTROMETRY; THIOPHENES; VOLUNTARY WORKERS;

EID: 33947674650     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2007.01.018     Document Type: Article

References (8)

1. Hunziker M.E., Suehs B.T., Bettinger T.L., and Crismon M.L. Duloxetine hydrochloride: a new dual-acting medication for the treatment of major depressive disorder. Clin Ther 27 8 (Aug 2005) 1126-1143
2. Westanmo A.D., Gayken J., and Haight R. Duloxetine: a balanced and selective norepinephrine-and serotonin-reuptake inhibitor. Am J Health-Syst Pharm 62 23 (Dec 1 2005) 2481-2490
3. Smith T.R. Duloxetine in diabetic neuropathy. Expert Opin Pharmacother (2006) 7215-7223
4. Jun I., Etsuko N., Akiniko T., et al. Simultaneous monitoring of inhibition of serotonin uptake by platelets and plasma drug concentrations following administration of duloxetine, a new antidepressant candidate, to healthy volunteers. Curr Ther Res 58 (1997) 679-691
5. Lantz R.J., Gillespie T.A., Rash T.J., et al. Metabolism, excretion, and pharmacokinetics of duloxetine in healthy human subjects. Drug Metab Dispos 31 (2003) 1142-1150
6. Skinner M.H., Kuan H.Y., Skerjanec A., et al. Effect of age on the pharmacokinetics of duloxetine in women. Br J Clin Pharmacol 57 (2004) 54-61
7. Hua T.C., Pan A., Chan C., et al. Effect of duloxetine on tolterodine pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 57 (2004) 652-656
8. Suri A., Reddy S., Gonzales C., Knadler M.P., Branch R.A., and Skinner M.H. Duloxetine pharmacokinetics in cirrhotics compared with healthy subjects. Int J Clin Pharmacol Ther 43 (2005) 78-84