Tetramic and tetronic acids as β-secretase inhibitors

Drug Discovery Today

Volumn 12, Issue 7-8, 2007, Pages 345-346

  Edwards, Paul ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE; RESIN; TETRAMIC ACID DERIVATIVE; TETRONIC ACID DERIVATIVE;

ALZHEIMER DISEASE; AMIDATION; CATALYSIS; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IC 50; SHORT SURVEY; SOLID PHASE SYNTHESIS; STRUCTURE ANALYSIS;

EID: 33947643191     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2007.02.005     Document Type: Short Survey

References (5)

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2. Joachim C.L., and Selkoe D.J. The seminal role of beta-amyloid in the pathogenesis of Alzheimer disease. Alzheimer Dis. Assoc. Disord 6 (1992) 7-34
3. Selkoe D.J. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399 (1999) A31-A32
4. Li R., et al. Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 3632-3637
5. Larbig G., and Schmidt B. Synthesis of tetramic and tetronic acids as β-secretase inhibitors. J. Comb. Chem. 8 (2006) 480-490