A new method to assess drug sensitivity on breast tumor acute slices preparation

Annals of the New York Academy of Sciences

Volumn 1091, Issue , 2006, Pages 460-469

  Mestres, Pedro ^a   Morguet, Andrea ^a   Schmidt, Werner ^a   Kob, Axel ^b   Thedinga, Elke ^b  

^a SAARLAND UNIVERSITY   (Germany)

^b Bionas GmbH   (Germany)

Author keywords

Breast cancer; Cell respiration; Chemosensitivity; Drug screening; Extracellular acidification; Metabolic activity; Silicon sensor chips; Toxicity; Tumor slices

Indexed keywords

CYTOSTATIC AGENT; FLUORIDE SODIUM; OXYGEN; PACLITAXEL; POTASSIUM CYANIDE; SILICON;

ACIDIFICATION; ANAEROBIC METABOLISM; BREAST CANCER; CANCER CELL CULTURE; CELL DENSITY; CELL PROLIFERATION; CELL RESPIRATION; CELL STRUCTURE; CHEMOSENSITIVITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; DRUG SENSITIVITY; ELECTROCHEMICAL ANALYSIS; ELECTRON MICROSCOPY; GLYCOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; OXYGEN CONSUMPTION; THREE DIMENSIONAL IMAGING; ARTICLE; BREAST TUMOR; DIFFUSION CHAMBER; DRUG RESISTANCE; FEMALE; INSTRUMENTATION; METABOLISM; METHODOLOGY; MICROTOMY; PATHOLOGY; TIME; TISSUE PRESERVATION;

BREAST NEOPLASMS; DIFFUSION CHAMBERS, CULTURE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MICROTOMY; PACLITAXEL; POTASSIUM CYANIDE; SODIUM FLUORIDE; TIME FACTORS; TISSUE PRESERVATION;

EID: 33947606805     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1378.088     Document Type: Conference Paper

References (10)

1. MESTRES, P. 2001. Anticancer Drugs Chemosensitivity testing of human tumors using Si-sensor chips. 12 (Suppl. 4): A3.
2. MESTRES, P. 2003. Chemosensitivity testing of human tumors using Si-sensor chips. Recent Results Cancer Res., 161: 26-38.
3. KRASNA, L., I. NETIKOVA, A. CHALOUPKOVA, et al. 2003. Assessment of in vitro drug resistance of human breast cancer cells subcultured from biopsy specimens. Anticancer Res. 23: 2593-2600.
4. MESTRES, P., A. MORGUET, A. SCHOFER, et al. 2005. Applications of silicon sensor technologies to tumor tissue in vitro. In Methods in Molecular Medicine.Vol. 111: Chemosensitivity-Vol. 2: In vivo Models, Imaging and Molecular Regulators. R. D. Blumenthal, Ed.109-126. Humana Press, Inc. Totowa, NJ.
5. HAFNER, F. 2000. Cytosensor microphysiometer: technology and recent applications. Biosens. Bioelectron. 15: 149-158.
6. EKLUND, S.E., D. TAYLOR, E. KOZLOV, et al. 2004. A microphysiometer for simultaneous measurement of changes in extracellular glucose, lactate, oxygen and acidification rate. Anal. Chem. 76: 519-527.
7. BAUMANN, W., M. LEHMANN, M. BITZENHOFER, et al. 1999. Microelectronic sensor system for microphysiological application on living cells. Sensor Actuators B55: 77-89.
8. LEHMANN, M., W. BAUMANN, M. BRISCHWEIN, et al. 2000. Noninvasive measurement of cell membrane associated proton gradients by ionsensitive field effect transistor arrays for microphysiological and bioelectronical applications. Biosens. Bioelectron. 15: 117-124.
9. LEHMANN, M., W. BAUMANN, M. BRISCHWEIN, et al. 2001. Simultaneous measurement of cellular respiration and acidification with a single CMOS ISFET. Biosens. Bioelectron. 16: 195-203.
10. EHRET, R., W. BAUMANN, M. BRISCHWEIN, et al. 2001. Multiparametric microsensor chips for screening applications. Fresenius J. Anal. Chem. 369: 30-35.