Validation of a high-throughput in vitro alkaline elution/rat hepatocyte assay for DNA damage

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 629, Issue 1, 2007, Pages 49-63

  Gealy, Robert ^a   Wright Bourque, Jennifer L ^a   Kraynak, Andrew R ^a   McKelvey, Troy W ^a   Barnum, John E ^a   Storer, Richard D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Alkaline elution; Automation; Cytotoxicity; Genotoxicity; Hepatocyte; Validation

Indexed keywords

ALKALI; FLUORESCENT DYE;

ANIMAL CELL; ARTICLE; AUTOMATION; CELL ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DNA DEGRADATION; DNA STRAND BREAKAGE; ELUTION; GENETIC SCREENING; GENOTOXICITY; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; VALIDATION STUDY;

ANIMALS; BIOLOGICAL ASSAY; CELL SURVIVAL; CELLS, CULTURED; CHLOROPHENOLS; CHLORPHENIRAMINE; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; HYDROGEN-ION CONCENTRATION; MALE; MUTAGENICITY TESTS; MUTAGENS; NITROPHENOLS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOXICITY TESTS;

MAMMALIA; RATTUS;

EID: 33947605193     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2007.01.005     Document Type: Article

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