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Volumn 31, Issue 3, 2007, Pages 678-682

Striatal and nigral COX-2 expression after chronic typical and atypical neuroleptic administration in rats

Author keywords

Clozapine; Cyclooxygenases; Haloperidol; Neurodegeneration

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; CLOZAPINE; CYCLOOXYGENASE 2; HALOPERIDOL; NEUROLEPTIC AGENT; SODIUM CHLORIDE;

EID: 33947600533     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2006.12.022     Document Type: Article
Times cited : (3)

References (43)
  • 1
    • 0242485244 scopus 로고    scopus 로고
    • Oral dyskinesias and histopathological alterations in substantia nigral after long-term haloperidol treatment of old rats
    • Andreassen O.A., Ferrante R.J., Aamo T.O., Beal M.F., and Jorgensen H.A. Oral dyskinesias and histopathological alterations in substantia nigral after long-term haloperidol treatment of old rats. Neuroscience 122 (2003) 717-725
    • (2003) Neuroscience , vol.122 , pp. 717-725
    • Andreassen, O.A.1    Ferrante, R.J.2    Aamo, T.O.3    Beal, M.F.4    Jorgensen, H.A.5
  • 2
    • 0031661173 scopus 로고    scopus 로고
    • Aspirin and salicylate protect against MPTP-induced dopamine depletion in mice
    • Aubin N., Curet O., Deffois C., and Carter C. Aspirin and salicylate protect against MPTP-induced dopamine depletion in mice. J Neurochem 71 (1998) 1635-1642
    • (1998) J Neurochem , vol.71 , pp. 1635-1642
    • Aubin, N.1    Curet, O.2    Deffois, C.3    Carter, C.4
  • 4
    • 0037108979 scopus 로고    scopus 로고
    • COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure and expression
    • Chandrasekharan N.V., Dai H., Roos K.L., Evanson N.K., Tomsik J., Elton T.S., et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure and expression. Proc Natl Acad Sci U S A 99 (2002) 13926-13931
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 13926-13931
    • Chandrasekharan, N.V.1    Dai, H.2    Roos, K.L.3    Evanson, N.K.4    Tomsik, J.5    Elton, T.S.6
  • 5
    • 0028596029 scopus 로고
    • Basal ganglia abnormalities in tardive dyskinesia: possible relationship with duration of neuroleptic treatment
    • Dagalarrondo P., and Gattaz W.F. Basal ganglia abnormalities in tardive dyskinesia: possible relationship with duration of neuroleptic treatment. Eur Arch Psychiatry Clin Neurosci 24 (1994) 272-277
    • (1994) Eur Arch Psychiatry Clin Neurosci , vol.24 , pp. 272-277
    • Dagalarrondo, P.1    Gattaz, W.F.2
  • 6
    • 33745835107 scopus 로고    scopus 로고
    • Different parkinsonism models produce a time-dependent induction of COX-2 in the substantia nigra of rats
    • De Meira M., Braga A., Marques S., Bueno H., Tufik S., and Vital M.A.B.F. Different parkinsonism models produce a time-dependent induction of COX-2 in the substantia nigra of rats. Brain Res 1101 (2006) 117-125
    • (2006) Brain Res , vol.1101 , pp. 117-125
    • De Meira, M.1    Braga, A.2    Marques, S.3    Bueno, H.4    Tufik, S.5    Vital, M.A.B.F.6
  • 7
    • 0037031609 scopus 로고    scopus 로고
    • Cyclooxygenase-2-deficient mice are resistant to damage of dopaminergic neurons in the substantia nigra
    • Feng Z.H., Wang T.G., Li D.D., Fung P., Wilson B.C., Liu B., et al. Cyclooxygenase-2-deficient mice are resistant to damage of dopaminergic neurons in the substantia nigra. Neurosci Lett 329 (2002) 354-358
    • (2002) Neurosci Lett , vol.329 , pp. 354-358
    • Feng, Z.H.1    Wang, T.G.2    Li, D.D.3    Fung, P.4    Wilson, B.C.5    Liu, B.6
  • 8
    • 0034023921 scopus 로고    scopus 로고
    • Review of incidence studies of tardive dyskinesia associated with typical antipsychotics
    • Glazer W.M. Review of incidence studies of tardive dyskinesia associated with typical antipsychotics. J Clin Psychiatry 61 Suppl 4 (2000) 15-20
    • (2000) J Clin Psychiatry , vol.61 , Issue.SUPPL. 4 , pp. 15-20
    • Glazer, W.M.1
  • 9
    • 0034012175 scopus 로고    scopus 로고
    • Cyclooxygenase 2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture
    • Hewett S.J., Uliasz T.F., Vidwans A.S., and Hewett J.A. Cyclooxygenase 2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture. J Pharmacol Exp Ther 293 (2000) 417-425
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 417-425
    • Hewett, S.J.1    Uliasz, T.F.2    Vidwans, A.S.3    Hewett, J.A.4
  • 10
    • 0037019859 scopus 로고    scopus 로고
    • The role of cyclooxygenase 1 and 2 activity in prostaglandin E2 secretion by cultured human adult microglia: implications for Alzheimer's disease
    • Hoozemans J.J., Veerhuis R., Janssen I., van Elk E.J., Rozemuller A.J., and Eikelenboom P. The role of cyclooxygenase 1 and 2 activity in prostaglandin E2 secretion by cultured human adult microglia: implications for Alzheimer's disease. Brain Res 951 (2002) 218-226
    • (2002) Brain Res , vol.951 , pp. 218-226
    • Hoozemans, J.J.1    Veerhuis, R.2    Janssen, I.3    van Elk, E.J.4    Rozemuller, A.J.5    Eikelenboom, P.6
  • 11
    • 0346374790 scopus 로고    scopus 로고
    • JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease
    • Hunot S., Vila M., Teismann P., Davis R.J., Hirsch E.C., Pzedborski S., et al. JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 101 (2004) 665-670
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 665-670
    • Hunot, S.1    Vila, M.2    Teismann, P.3    Davis, R.J.4    Hirsch, E.C.5    Pzedborski, S.6
  • 12
    • 0002902726 scopus 로고
    • Tardive dyskinesia: epidemiology and clinical presentation
    • Bloom F.E., and Kupfer D.J. (Eds), Raven Press, New York
    • Kane J.M. Tardive dyskinesia: epidemiology and clinical presentation. In: Bloom F.E., and Kupfer D.J. (Eds). Psychopharmacology: the fourth generation of progress vol. 39 (1995), Raven Press, New York 1485-1495
    • (1995) Psychopharmacology: the fourth generation of progress , vol.39 , pp. 1485-1495
    • Kane, J.M.1
  • 14
    • 0035838273 scopus 로고    scopus 로고
    • Differential roles of cyclooxygenase isoforms after kainic acid-induced prostaglandins E2 production and neurodegeneration in cortical and hippocampal cell cultures
    • Kim E.J., Lee J.E., Know K.J., Lee S.H., Moon C.H., and Baik E.J. Differential roles of cyclooxygenase isoforms after kainic acid-induced prostaglandins E2 production and neurodegeneration in cortical and hippocampal cell cultures. Brain Res 908 (2001) 1-9
    • (2001) Brain Res , vol.908 , pp. 1-9
    • Kim, E.J.1    Lee, J.E.2    Know, K.J.3    Lee, S.H.4    Moon, C.H.5    Baik, E.J.6
  • 15
    • 0034520395 scopus 로고    scopus 로고
    • Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2
    • Knott C., Stern G., and Wilkin G.P. Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2. Mol Cell Neurosci 16 (2000) 724-739
    • (2000) Mol Cell Neurosci , vol.16 , pp. 724-739
    • Knott, C.1    Stern, G.2    Wilkin, G.P.3
  • 16
    • 0035071894 scopus 로고    scopus 로고
    • Tardive dyskinesia: an update
    • Kulkarni S.K., and Naidu P.S. Tardive dyskinesia: an update. Drugs Today 37 (2001) 97-119
    • (2001) Drugs Today , vol.37 , pp. 97-119
    • Kulkarni, S.K.1    Naidu, P.S.2
  • 17
    • 0031935752 scopus 로고    scopus 로고
    • Haloperidol induces persistent down-regulation of tyrosine hydroxylase immunoreactivity in substantia nigra but not ventral tegmental area in the rat
    • Levinson A.J., Garside S., Rosebush P.I., and Mazurek M.F. Haloperidol induces persistent down-regulation of tyrosine hydroxylase immunoreactivity in substantia nigra but not ventral tegmental area in the rat. Neuroscience 84 (1998) 201-211
    • (1998) Neuroscience , vol.84 , pp. 201-211
    • Levinson, A.J.1    Garside, S.2    Rosebush, P.I.3    Mazurek, M.F.4
  • 19
    • 0036457014 scopus 로고    scopus 로고
    • Sub-chronic treatment with classical but not atypical antipsychotics produces morphological changes in rat nigrostriatal dopaminergic neurons directly related to "early onset" vacuous chewing
    • Marchese G., Casu M.A., Bartholini F., Ruiu S., Saba P., Gessa G.L., et al. Sub-chronic treatment with classical but not atypical antipsychotics produces morphological changes in rat nigrostriatal dopaminergic neurons directly related to "early onset" vacuous chewing. Eur J Neurosci 15 (2002) 1187-1196
    • (2002) Eur J Neurosci , vol.15 , pp. 1187-1196
    • Marchese, G.1    Casu, M.A.2    Bartholini, F.3    Ruiu, S.4    Saba, P.5    Gessa, G.L.6
  • 20
    • 0346096594 scopus 로고    scopus 로고
    • Ritanserin counteracts both rat vacuous chewing movements and nigro-striatal tyrosine hydroxylase-immunostaining alterations induced by haloperidol
    • Marchese G., Bartholini F., Ruiu S., Casti P., Casu G.L., and Pani L. Ritanserin counteracts both rat vacuous chewing movements and nigro-striatal tyrosine hydroxylase-immunostaining alterations induced by haloperidol. Eur J Pharmacol 483 (2004) 65-69
    • (2004) Eur J Pharmacol , vol.483 , pp. 65-69
    • Marchese, G.1    Bartholini, F.2    Ruiu, S.3    Casti, P.4    Casu, G.L.5    Pani, L.6
  • 21
    • 0030603155 scopus 로고    scopus 로고
    • Effect of long-term haloperidol treatment on striatal neuropeptides: relation to stereotyped behavior
    • Marin C., Engber T.M., Bonastre M., Chase T.N., and Tolosa E. Effect of long-term haloperidol treatment on striatal neuropeptides: relation to stereotyped behavior. Brain Res 731 (1996) 57-62
    • (1996) Brain Res , vol.731 , pp. 57-62
    • Marin, C.1    Engber, T.M.2    Bonastre, M.3    Chase, T.N.4    Tolosa, E.5
  • 22
    • 0029912561 scopus 로고    scopus 로고
    • Striatal c-fos levels do not correlate with haloperidol-induced behavioral supersensitivity
    • Marin C., Bonastre M., and Tolosa E. Striatal c-fos levels do not correlate with haloperidol-induced behavioral supersensitivity. Synapse 23 (1996) 89-93
    • (1996) Synapse , vol.23 , pp. 89-93
    • Marin, C.1    Bonastre, M.2    Tolosa, E.3
  • 23
    • 0031778457 scopus 로고    scopus 로고
    • Persistent loss of tyrosine hydroxylase immunoreactivity in the substantia nigra after neuroleptic withdrawal
    • Mazurek M.F., Savedia S.M., Bobba R.S., Garside S., and Rosebush P.I. Persistent loss of tyrosine hydroxylase immunoreactivity in the substantia nigra after neuroleptic withdrawal. J Neurol Neurosurg Psychiatry 64 (1998) 799-801
    • (1998) J Neurol Neurosurg Psychiatry , vol.64 , pp. 799-801
    • Mazurek, M.F.1    Savedia, S.M.2    Bobba, R.S.3    Garside, S.4    Rosebush, P.I.5
  • 24
    • 0026808298 scopus 로고
    • Effect of haloperidol and clozapine on the density of "perforated" synapses in caudate, nucleus acumbens and medial prefrontal cortex
    • Meshul C.K., Janowsky A., Casey D.E., Stalbaumer R.K., and Taylor B. Effect of haloperidol and clozapine on the density of "perforated" synapses in caudate, nucleus acumbens and medial prefrontal cortex. Psychopharmacology 106 (1992) 45-52
    • (1992) Psychopharmacology , vol.106 , pp. 45-52
    • Meshul, C.K.1    Janowsky, A.2    Casey, D.E.3    Stalbaumer, R.K.4    Taylor, B.5
  • 25
    • 0028305817 scopus 로고
    • Haloperidol-induced morphological changes in striatum are associated with glutamate synapses
    • Meshul C.K., Stallbaumer R.K., Taylor B., and Janowsky A. Haloperidol-induced morphological changes in striatum are associated with glutamate synapses. Brain Res 648 (1994) 181-195
    • (1994) Brain Res , vol.648 , pp. 181-195
    • Meshul, C.K.1    Stallbaumer, R.K.2    Taylor, B.3    Janowsky, A.4
  • 26
    • 0037126991 scopus 로고    scopus 로고
    • Acute administration of haloperidol induces apoptosis of neurones in the striatum and substantia nigra in the rat
    • Mitchell I.J., Cooper A.C., Griffiths M.R., and Cooper A.J. Acute administration of haloperidol induces apoptosis of neurones in the striatum and substantia nigra in the rat. Neuroscience 109 (2002) 89-99
    • (2002) Neuroscience , vol.109 , pp. 89-99
    • Mitchell, I.J.1    Cooper, A.C.2    Griffiths, M.R.3    Cooper, A.J.4
  • 27
    • 0035798384 scopus 로고    scopus 로고
    • Possible involvement of prostaglandins in haloperidol-induced orofacial dyskinesia in rats
    • Naidu P.S., and Kulkarni S.K. Possible involvement of prostaglandins in haloperidol-induced orofacial dyskinesia in rats. Eur J Pharmacol 430 (2001) 295-298
    • (2001) Eur J Pharmacol , vol.430 , pp. 295-298
    • Naidu, P.S.1    Kulkarni, S.K.2
  • 28
    • 0036592439 scopus 로고    scopus 로고
    • Differential effects of cyclooxygenase inhibitors on haloperidol-induced catalepsy
    • Naidu P.S., and Kulkarni S.K. Differential effects of cyclooxygenase inhibitors on haloperidol-induced catalepsy. Prog Neuro-Psycopharmacol Biol Psychiatry (2002) 819-822
    • (2002) Prog Neuro-Psycopharmacol Biol Psychiatry , pp. 819-822
    • Naidu, P.S.1    Kulkarni, S.K.2
  • 29
    • 0022497921 scopus 로고
    • Possible involvement of prostaglandins in cataleptic behavior in rats
    • Ono N., Saito R., Abiru T., Kamiya H.O., and Tatsuo F. Possible involvement of prostaglandins in cataleptic behavior in rats. Pharmacol Biochem Behav 25 (1986) 463-471
    • (1986) Pharmacol Biochem Behav , vol.25 , pp. 463-471
    • Ono, N.1    Saito, R.2    Abiru, T.3    Kamiya, H.O.4    Tatsuo, F.5
  • 30
    • 0023930824 scopus 로고
    • Effect of aspirin on haloperidol-induced cataleptic behavior in mice
    • Ono N., Saito R., Abiru T., Matsushita Y., and Kamiya H. Effect of aspirin on haloperidol-induced cataleptic behavior in mice. Neuropharmacology 27 (1988) 327-329
    • (1988) Neuropharmacology , vol.27 , pp. 327-329
    • Ono, N.1    Saito, R.2    Abiru, T.3    Matsushita, Y.4    Kamiya, H.5
  • 31
    • 0026574295 scopus 로고
    • Influence of cyclooxygenase inhibitors on the cataleptic behavior induced by haloperidol in mice
    • Ono N., Abiru T., Sugiyama K., and Kamiya H. Influence of cyclooxygenase inhibitors on the cataleptic behavior induced by haloperidol in mice. Prostaglandins Leukot Essent Fat Acids 46 (1992) 59-63
    • (1992) Prostaglandins Leukot Essent Fat Acids , vol.46 , pp. 59-63
    • Ono, N.1    Abiru, T.2    Sugiyama, K.3    Kamiya, H.4
  • 32
    • 4043167628 scopus 로고    scopus 로고
    • Cyclooxygenases mRNA and protein expression in striata in the experimental mouse model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to mouse
    • Przybylkowski A., Kurkowska-Jastrzebska I., Joniex I., Ciesielska A., Czlonkowska A., and Czlonkowski A. Cyclooxygenases mRNA and protein expression in striata in the experimental mouse model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to mouse. Brain Res 1019 (2004) 144-151
    • (2004) Brain Res , vol.1019 , pp. 144-151
    • Przybylkowski, A.1    Kurkowska-Jastrzebska, I.2    Joniex, I.3    Ciesielska, A.4    Czlonkowska, A.5    Czlonkowski, A.6
  • 33
    • 0028147689 scopus 로고
    • MPP(+)-like neurotoxicity of a pyridinium metabolite derived from haloperidol: in vivo microdialysis and in vitro mitochondrial studies
    • Rollema H., Skolnik M., D'Engelbronner J., Igarashi K., Usuki E., and Castagnoli Jr. N. MPP(+)-like neurotoxicity of a pyridinium metabolite derived from haloperidol: in vivo microdialysis and in vitro mitochondrial studies. J Pharmacol Exp Ther 268 (1994) 380-387
    • (1994) J Pharmacol Exp Ther , vol.268 , pp. 380-387
    • Rollema, H.1    Skolnik, M.2    D'Engelbronner, J.3    Igarashi, K.4    Usuki, E.5    Castagnoli Jr., N.6
  • 34
    • 0030756517 scopus 로고    scopus 로고
    • A comparison of clozapine and haloperidol in hospitalized patients with refractory schizophrenia. Department of Veterans Affairs Cooperative Study group on clozapine in refractory schizophrenia
    • Rosenheck R., Cramer J., Xu W., Thomas J., Henderson W., Frisman K., et al. A comparison of clozapine and haloperidol in hospitalized patients with refractory schizophrenia. Department of Veterans Affairs Cooperative Study group on clozapine in refractory schizophrenia. N Engl J Med 337 (1997) 809-815
    • (1997) N Engl J Med , vol.337 , pp. 809-815
    • Rosenheck, R.1    Cramer, J.2    Xu, W.3    Thomas, J.4    Henderson, W.5    Frisman, K.6
  • 35
    • 0037459783 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drug sodium salicylate, but not diclofenac or celecoxib, protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats
    • Sairam K., Saravanan K.S., Banerjee R., and Mohanakumar K.P. Non-steroidal anti-inflammatory drug sodium salicylate, but not diclofenac or celecoxib, protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats. Brain Res 966 (2003) 245-252
    • (2003) Brain Res , vol.966 , pp. 245-252
    • Sairam, K.1    Saravanan, K.S.2    Banerjee, R.3    Mohanakumar, K.P.4
  • 36
    • 33748157826 scopus 로고    scopus 로고
    • Role pf NFkB p50 and p65 subunits expression in haloperidol-induced neurotoxicity and stereotyped behavior
    • Saldaña M., Bonastre M., Aguilar E., and Marin C. Role pf NFkB p50 and p65 subunits expression in haloperidol-induced neurotoxicity and stereotyped behavior. Eur Neuropsychopharmacol 16 (2006) 491-497
    • (2006) Eur Neuropsychopharmacol , vol.16 , pp. 491-497
    • Saldaña, M.1    Bonastre, M.2    Aguilar, E.3    Marin, C.4
  • 37
    • 33947583184 scopus 로고    scopus 로고
    • Saldaña M, Bonastre M, Aguilar E, Marin C, (in press). Differential nigral expression of bcl-2 protein family in chronically haloperidol and clozapine-treated rats: Role in neurotoxicity and stereotyped behavior. Exp Neurol.
  • 38
    • 4344645719 scopus 로고    scopus 로고
    • Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease
    • Sanchez-Pernaute R., Ferre A., Cooper O., Yu M., Brownell A.L., and Issacson O. Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease. J Neuroinflammation 1 (2004) 6
    • (2004) J Neuroinflammation , vol.1 , pp. 6
    • Sanchez-Pernaute, R.1    Ferre, A.2    Cooper, O.3    Yu, M.4    Brownell, A.L.5    Issacson, O.6
  • 40
    • 18044384646 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is and obligatory factor in methamphetamine-induced neurotoxicity
    • Thomas D.M., and Kuhn D.M. Cyclooxygenase-2 is and obligatory factor in methamphetamine-induced neurotoxicity. J Pharmacol Exp Ther 313 (2005) 870-876
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 870-876
    • Thomas, D.M.1    Kuhn, D.M.2
  • 41
    • 2642545991 scopus 로고    scopus 로고
    • Neurotoxic potential of haloperidol in comparison with risperidone: implication of Akt-mediated signal changes by haloperidol
    • Ukai W., Ozawa H., Tateno M., Hashimoto E., and Saito T. Neurotoxic potential of haloperidol in comparison with risperidone: implication of Akt-mediated signal changes by haloperidol. J Neural Transm 111 (2004) 667-681
    • (2004) J Neural Transm , vol.111 , pp. 667-681
    • Ukai, W.1    Ozawa, H.2    Tateno, M.3    Hashimoto, E.4    Saito, T.5
  • 42
    • 33645867671 scopus 로고    scopus 로고
    • Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease
    • Vijitruth R., Liu M., Choi D.Y., Nguyen X.V., Hunter R.L., and Bing G. Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease. J Neuroinflammation 3 (2006) 6
    • (2006) J Neuroinflammation , vol.3 , pp. 6
    • Vijitruth, R.1    Liu, M.2    Choi, D.Y.3    Nguyen, X.V.4    Hunter, R.L.5    Bing, G.6
  • 43
    • 0032053811 scopus 로고    scopus 로고
    • In vivo analysis of hydrogen peroxide and lipid radicals in the striatum of rats under long-term administration of a neuroleptic
    • Yokoyama H., Kasai N., Ueda Y., Niwa R., Konaka R., Mori N., et al. In vivo analysis of hydrogen peroxide and lipid radicals in the striatum of rats under long-term administration of a neuroleptic. Free Radic Biol Med 24 (1998) 1056-1060
    • (1998) Free Radic Biol Med , vol.24 , pp. 1056-1060
    • Yokoyama, H.1    Kasai, N.2    Ueda, Y.3    Niwa, R.4    Konaka, R.5    Mori, N.6


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