Local treatment of ectopic pregnancy

Seminars in Reproductive Medicine

Volumn 25, Issue 2, 2007, Pages 99-115

  Raughley, Moune Jabre ^a   Frishman, Gary Nathan ^a  

^a WOMEN AND INFANTS HOSPITAL   (United States)

Author keywords

Ectopic pregnancy; Local treatment; Methatrexate; Potassium chloride; Transvaginal ultrasound

Indexed keywords

15 METHYLPROSTAGLANDIN E2ALPHA; DANAZOL; ETOPOSIDE; FENTANYL; FOLINATE CALCIUM; GLUCOSE; LIDOCAINE; METHOTREXATE; MIFEPRISTONE; POTASSIUM CHLORIDE; PROSTAGLANDIN; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; UNCLASSIFIED DRUG; VASOPRESSIN;

CLINICAL TRIAL; DIAGNOSTIC IMAGING; DRUG ADMINISTRATION ROUTE; DRUG SAFETY; ECTOPIC PREGNANCY; FEMALE; HUMAN; INTRATUBAL DRUG ADMINISTRATION; LAPAROSCOPY; OBSTETRIC OPERATION; REVIEW; TRANSVAGINAL ECHOGRAPHY; TREATMENT CONTRAINDICATION; TREATMENT FAILURE; TREATMENT OUTCOME; UTERINE TUBE;

ABORTIFACIENT AGENTS, NONSTEROIDAL; DANAZOL; ETOPOSIDE; FALLOPIAN TUBES; FEMALE; GLUCOSE; HUMANS; LAPAROSCOPY; METHOTREXATE; POTASSIUM CHLORIDE; PREGNANCY; PREGNANCY, ECTOPIC; PROSTAGLANDINS; SALPINGOSTOMY; ULTRASONOGRAPHY, PRENATAL;

EID: 33947598708     PISSN: 15268004     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-970049     Document Type: Review

References (74)

1. Hreshchyshyn MM, Naples JD Jr, Randall CL. Amethopterin in abdominal pregnancy. Am J Obstet Gynecol 1965; 93:286-287
2. Tanaka T, Hayashi H, Kutsuzawa T, Fujimoto S, Ichinoe K. Treatment of interstitial ectopic pregnancy with methotrexate: report of a successful case. Fertil Steril 1982;37(6):851-852
3. Feichtinger W, Kemeter P. Conservative treatment of ectopic pregnancy by transvaginal aspiration under sonographic control and methotrexate injection. Lancet 1987;1(8529): 381-382
4. Dimitry ES, Subak-Sharpe R, Mills M, Margara R, Winston R. Nine cases of heterotopic pregnancies in 4 years of in vitro fertilization. Fertil Steril 1990;53(1):107-110
5. Parente JT, Ou CS, Levy J, Legatt E. Cervical pregnancy analysis: a review and report of five cases. Obstet Gynecol 1983;62(1):79-82
6. Ushakov FB, Elchalal U, Aceman PJ, Schenker JG. Cervical pregnancy: past and future. Obstet Gynecol Surv 1997; 52(1):45-59
7. Barnhart K, Spandorfer S, Coutifaris C. Medical treatment of interstitial pregnancy. A report of three unsuccessful cases. J Reprod Med 1997;42(8):521-524
8. Voigt RR, van der Veen F, Karsdorp VH, Hogerzeil HV, Ketting BW. Treatment of interstitial pregnancy with methotrexate: report of an unsuccessful case. Hum Reprod 1994;9(8):1576-1579
9. Bai SW, Lee JS, Park JH, et al. Failed methotrexate treatment of cervical pregnancy. Predictive factors. J Reprod Med 2002;47(6):483-488
10. Timor-Tritsch IE, Monteagudo A, Mandeville EO, Peisner DB, Anaya GP, Pirrone EC. Successful management of viable cervical pregnancy by local injection of methotrexate guided by transvaginal ultrasonography. Am J Obstet Gynecol 1994;170(3):737-739
11. Frishman GN. Transvaginal ultrasound-guided methotrexate injection of cornual ectopic pregnancy. J Am Assoc Gynecol Laparosc 2004;11(1):1
12. Perez JA, Sadek MM, Savale M, Boyer P, Zorn JR. Local medical treatment of interstitial pregnancy after in-vitro fertilization and embryo transfer (IVF-ET): two case reports. Hum Reprod 1993;8(4):631-634
13. Stovall TG, Ling FW, Buster JE. Reproductive performance after methotrexate treatment of ectopic pregnancy. Am J Obstet Gynecol 1990;162(6):1620-1623 [discussion 3-4]
14. Medical management of tubal pregnancy. ACOG Practice Bulletin Number 3, December 1998. Clinical management guidelines for obstetrician-gynecologists. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet 1999;65(1):97-103
15. Kooi S, Kock HC. Treatment of tubal pregnancy by local injection of methotrexate after adrenaline injection into the mesosalpinx: a report of 25 patients. Fertil Steril 1990; 54(4):580-584
16. Gjelland K, Hordnes K, Tjugum J, Augensen K, Bergsjo P. Treatment of ectopic pregnancy by local injection of hypertonic glucose: a randomized trial comparing administration guided by transvaginal ultrasound or laparoscopy. Acta Obstet Gynecol Scand 1995;74(8):629-634
17. Darai E, Benifla JL, Naouri M, et al. Transvaginal intratubal methotrexate treatment of ectopic pregnancy. Report of 100 cases. Hum Reprod 1996;11(2):420-424
18. Merz E, Bahlmann F, Weber G, et al. Unruptured tubal pregnancy: local low-dose therapy with methotrexate under transvaginal ultrasonographic guidance. Gynecol Obstet Invest 1996;41(2):76-81
19. Mesogitis SA, Daskalakis GJ, Antsaklis AJ, Papantoniou NE, Papageorgiou JS, Michalas SK. Local application of methotrexate for ectopic pregnancy with a percutaneous puncturing technique. Gynecol Obstet Invest 1998;45(3): 154-158
20. Yeko TR, Mayer JC, Parsons AK, Maroulis GB. A prospective series of unruptured ectopic pregnancies treated by tubal injection with hyperosmolar glucose. Obstet Gynecol 1995;85(2):265-268
21. Fernandez H, Yves Vincent SC, Pauthier S, Audibert F, Frydman R. Randomized trial of conservative laparoscopic treatment and methotrexate administration in ectopic pregnancy and subsequent fertility. Hum Reprod 1998; 13(11):3239-3243
22. Ory SJ, Villanueva AL, Sand PK, Tamura RK. Conservative treatment of ectopic pregnancy with methotrexate. Am J Obstet Gynecol 1986;154(6):1299-1306
23. Kooi S, van Etten FH, Kock HC. Histopathology of five tubes after treatment with methotrexate for a tubal pregnancy. Fertil Steril 1992;57(2):341-345
24. Fernandez H, Bourget P, Ville Y, Lelaidier C, Frydman R. Treatment of unruptured tubal pregnancy with methotrexate: pharmacokinetic analysis of local versus intramuscular administration. Fertil Steril 1994;62(5):943-947
25. Schiff E, Shalev E, Bustan M, Tsabari A, Mashiach S, Weiner E. Pharmacokinetics of methotrexate after local tubal injection for conservative treatment of ectopic pregnancy. Fertil Steril 1992;57(3):688-690
26. Pansky M, Bukovsky I, Golan A, et al. Local methotrexate injection: a nonsurgical treatment of ectopic pregnancy. Am J Obstet Gynecol 1989;161(2):393-396
27. Pansky M, Bukovsky J, Golan A, et al. Reproductive outcome after laparoscopic local methotrexate injection for tubal pregnancy. Fertil Steril 1993;60(1):85-87
28. Tulandi T, Bret PM, Atri M, Senterman M. Treatment of ectopic pregnancy by transvaginal intratubal methotrexate administration. Obstet Gynecol 1991;77(4):627-630
29. Hoek A, Broekmans FJ, Verheijen RH, Schats R. Successful treatment of an advanced interstitial pregnancy by sequential systemic and local administration of methotrexate. Hum Reprod 1995;10(7):1864-1865
30. Fernandez H, Benifla JL, Lelaidier C, Baton C, Frydman R. Methotrexate treatment of ectopic pregnancy: 100 cases treated by primary transvaginal injection under sonographic control. Fertil Steril 1993;59(4):773-777
31. Hwu YM, Hsu CY, Yang HY. Conservative treatment of caesarean scar pregnancy with transvaginal needle aspiration of the embryo. BJOG 2005;112(6):841-842
32. Evans MI, Britt DW. Fetal reduction. Semin Perinatol 2005;29(5):321-329
33. Monteagudo A, Tarricone NJ, Timor-Tritsch IE, Lerner JP. Successful transvaginal ultrasound-guided puncture and injection of a cervical pregnancy in a patient with simultaneous intrauterine pregnancy and a history of a previous cervical pregnancy. Ultrasound Obstet Gynecol 1996;8(6): 381-386
34. Fernandez H, Lelaidier C, Doumerc S, Fournet P, Olivennes F, Frydman R. Nonsurgical treatment of heterotopic pregnancy: a report of six cases. Fertil Steril 1993;60(3): 428-432
35. Timor-Tritsch I, Baxi L, Peisner DB. Transvaginal salpingocentesis: a new technique for treating ectopic pregnancy. Am J Obstet Gynecol 1989;160(2):459-461
36. Doubilet PM, Benson CB, Frates MC, Ginsburg E. Sonographically guided minimally invasive treatment of unusual ectopic pregnancies. J Ultrasound Med 2004;23(3): 359-370
37. Lang PF, Tamussino K, Honigl W, Ralph G. Treatment of unruptured tubal pregnancy by laparoscopic instillation of hyperosmolar glucose solution. Am J Obstet Gynecol 1992;166(5):1378-1381
38. Makhlouf AM, Al-Hussaini TK, Habib DM, Makarem MH. Second-trimester pregnancy termination: comparison of three different methods. J Obstet Gynaecol 2003;23(4): 407-411
39. Hahlin M, Bokstrom H, Lindblom B. Ectopic pregnancy: in vitro effects of prostaglandins on the oviduct and corpus luteum. Fertil Steril 1987;47(6):935-940
40. Vejtorp M, Vejerslev LO, Ruge S. Local prostaglandin treatment of ectopic pregnancy. Hum Reprod 1989;4(4):464-467
41. Vejtorp M, Vejerslev LO, Ruge S. Treatment of tubal pregnancy by local injection of prostaglandin: selection of patients and evaluation of subsequent tubal patency. Eur J Obstet Gynecol Reprod Biol 1991;41(2):85-90
42. Lindblom B, Hahlin M, Lundorff P, Thorburn J. Treatment of tubal pregnancy by laparoscope-guided injection of prostaglandin F2 alpha. Fertil Steril 1990;54(3):404-408
43. Ali AF. Local danazol injection for treatment of unruptured tubal pregnancy (preliminary experience). Eur J Obstet Gynecol Reprod Biol 1993;49(3):137-141
44. Kusaka M, Tanaka T, Fujimoto S. Local etoposide injection for treatment of tubal pregnancy with cardiac activity. Int J Fertil Menopausal Stud 1994;39(1):11-13
45. Yildizhan B. Diagnosis and treatment of early cervical pregnancy: a case report and literature review. Clin Exp Obstet Gynecol 2005;32(4):254-256
46. Tasdemir M, Tasdemir S. Minimally invasive treatment of live ectopic pregnancy. Clin Exp Obstet Gynecol 1997; 24(2):92
47. Yazici G, Aban M, Arslan M, Pata O, Oz U. Treatment of a cervical viable pregnancy with a single intraamniotic methotrexate injection: a case report. Arch Gynecol Obstet 2004;270(1):61-63
48. Hung TH, Shau WY, Hsieh TT, Hsu JJ, Soong YK, Jeng CJ. Prognostic factors for an unsatisfactory primary methotrexate treatment of cervical pregnancy: a quantitative review. Hum Reprod 1998;13(9):2636-2642
49. Kung FT, Chang SY. Efficacy of methotrexate treatment in viable and nonviable cervical pregnancies. Am J Obstet Gynecol 1999;181(6):1438-1444
50. Lang PF, Weiss PA, Mayer HO, Haas JG, Honigl W. Conservative treatment of ectopic pregnancy with local injection of hyperosmolar glucose solution or prostaglandin-F2 alpha: a prospective randomised study. Lancet 1990; 336(8707):78-81
51. Batioglu S, Haberal A, Yesilyurt H, Ekici E. Successful treatment of cornual pregnancy by local injection of methotrexate under laparoscopic and transvaginal ultrasonographic guidance. Gynecol Obstet Invest 1997;44(1):64-66
52. Natofsky JG, Lense J, Mayer JC, Yeko TR. Ultrasound-guided injection of ectopic pregnancy. Clin Obstet Gynecol 1999;42(1):39-47
53. Brown DL, Doubilet PM. Transvaginal sonography for diagnosing ectopic pregnancy: positivity criteria and performance characteristics. J Ultrasound Med 1994;13(4):259-266
54. Laatikainen T, Tuomivaara L, Kaar K. Comparison of a local injection of hyperosmolar glucose solution with salpingostomy for the conservative treatment of tubal pregnancy. Fertil Steril 1993;60(1):80-84
55. Porpora MG, Oliva MM, De Cristofaro A, Montanino G, Cosmi EV. Comparison of local injection of methotrexate and linear salpingostomy in the conservative laparoscopic treatment of ectopic pregnancy. J Am Assoc Gynecol Laparosc 1996;3(2):271-276
56. Mottla GL, Rulin MC, Guzick DS. Lack of resolution of ectopic pregnancy by intratubal injection of methotrexate. Fertil Steril 1992;57(3):685-687
57. Fernandez H, Pauthier S, Doumerc S, et al. Ultrasound-guided injection of methotrexate versus laparoscopic salpingotomy in ectopic pregnancy. Fertil Steril 1995;63(1): 25-29
58. Hajenius PJ, Mol BW, Bossuyt PM, Ankum WM, Van Der Veen F. Interventions for tubal ectopic pregnancy. Cochrane Database Syst Rev 2000;2:CD000324
59. Tzafettas J, Anapliotis S, Zournatzi V, Boucklis A, Oxouzoglou N, Bondis J. Transvaginal intra-amniotic injection of methotrexate in early ectopic pregnancy. Advantages over the laparoscopic approach. Early Hum Dev 1994;39(2):101-107
60. Cohen DR, Falcone T, Khalife S. Methotrexate: local versus intramuscular. [comment]. Fertil Steril 1996;65(1): 206-207
61. Goldenberg M, Bider D, Oelsner G, Admon D, Mashiach S. Treatment of interstitial pregnancy with methotrexate via hysteroscopy. Fertil Steril 1992;58(6):1234-1236
62. Risquez F, Mathieson J, Pariente D, et al. Diagnosis and treatment of ectopic pregnancy by retrograde selective salpingography and intraluminal methotrexate injection: work in progress. Hum Reprod 1990;5(6):759-762
63. Kiss H, Egarter C, Wenzl R, Husslein P. Falloposcopic instillation of prostaglandin in tubal pregnancy. Lancet 1993; 342(8862):54
64. Kaya H, Babar Y, Ozmen S, et al. Intratubal methotrexate for prevention of persistent ectopic pregnancy after salpingotomy. J Am Assoc Gynecol Laparosc 2002;9(4):464-467
65. Graczykowski JW, Mishell DR Jr. Methotrexate prophylaxis for persistent ectopic pregnancy after conservative treatment by salpingostomy. Obstet Gynecol 1997;89(1): 118-122
66. Fujishita A, Ishimaru T, Masuzaki H, et al. Local injection of methotrexate dissolved in saline versus methotrexate suspensions for the conservative treatment of ectopic pregnancy. Hum Reprod 1995;10(12):3280-3283
67. Egarter C, Kiss H, Vavra N, Husslein P. Reproductive performance after local and systemic prostaglandin for ectopic pregnancy. Arch Gynecol Obstet 1992;252(1):45-48
68. Bonatz G, Lehmann-Willenbrock E, Kunstmann P, Semm I, Hedderich J, Semm K. Management of patients with persistent beta-hCG values following laparoscopic surgical and local drug treatment for ectopic pregnancy. Int J Gynaecol Obstet 1994;47(1):33-38
69. Honigl W, Pickel H, Tamussino K, Lang PF. Histopathology of the fallopian tube after local instillation of hyperosmolar glucose solution for unruptured tubal pregnancy. Fertil Steril 1993;59(6):1316-1318
70. Klinkert J, van Geldorp HJ, Chadha-Ajwani S, Huikeshoven FJ. Tubal damage after intratubal methotrexate treatment. Fertil Steril 1993;59(4):926-927
71. Buster JE, Carson SA. Ectopic pregnancy: new advances in diagnosis and treatment. Curr Opin Obstet Gynecol 1995;7(3):168-176
72. Timor-Tritsch IE, Monteagudo A, Matera C, Veit CR. Sonographic evolution of cornual pregnancies treated without surgery. Obstet Gynecol 1992;79(6):1044-1049
73. Hajenius PJ, Mol BW, Ankum WM, van der Veen F, Bossuyt PM, Lammes FB. Suspected ectopic pregnancy: expectant management in patients with negative sonographic findings and low serum hCG concentrations. Early Pregnancy 1995;1(4):258-262
74. Ankum WM, Van der Veen F, Hamerlynck JV, Lammes FB. Suspected ectopic pregnancy. What to do when human chorionic gonadotropin levels are below the discriminatory zone. J Reprod Med 1995;40(7):525-528