Novel thiol-based TACE inhibitors: Rational design, synthesis, and SAR of thiol-containing aryl sulfonamides

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 8, 2007, Pages 2250-2253

  Govinda Rao, B ^a   Bandarage, Upul K ^a   Wang, Tiansheng ^a   Come, Jon H ^a   Perola, Emanuele ^a   Wei, Yunyi ^a   Tian, Shi Kai ^a   Saunders, Jeffrey O ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

Hydroxamates; MMP selectivity; Rheumatoid arthritis; TACE inhibitors; Thiols

Indexed keywords

COLLAGENASE 3; GELATINASE A; GELATINASE B; MATRILYSIN; NEUTROPHIL COLLAGENASE; SULFONAMIDE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ADAM PROTEINS; ARTHRITIS, RHEUMATOID; CROHN DISEASE; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; METALLOPROTEASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SULFHYDRYL COMPOUNDS; SULFONAMIDES;

EID: 33947591481     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.064     Document Type: Article

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