Medical therapy for ectopic pregnancy

Seminars in Reproductive Medicine

Volumn 25, Issue 2, 2007, Pages 93-98

  Lipscomb, Gary H ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Ectopic pregnancy; Methotrexate; Therapy

Indexed keywords

CHORIONIC GONADOTROPIN BETA SUBUNIT; FOLINATE CALCIUM; IBUPROFEN; METHOTREXATE;

BLOATING; BONE MARROW SUPPRESSION; CLINICAL PROTOCOL; CONSERVATIVE TREATMENT; CURETTAGE; DOSAGE SCHEDULE COMPARISON; DRUG CLEARANCE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG EXCRETION; FEMALE; FLATULENCE; HEMATOMA; HUMAN; KIDNEY FAILURE; LIVER CIRRHOSIS; LIVER FUNCTION; LUNG FIBROSIS; MULTIPLE CYCLE TREATMENT; NAUSEA; OUTCOME ASSESSMENT; PAIN; PNEUMONIA; PREDICTION; REVIEW; SIDE EFFECT; SINGLE DRUG DOSE; STOMACH ULCER; STOMATITIS; TREATMENT OUTCOME; URINARY EXCRETION; UTERINE CERVIX DILATATION; UTERINE TUBE PREGNANCY;

ABORTIFACIENT AGENTS, NONSTEROIDAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; METHOTREXATE; PREGNANCY; PREGNANCY, ECTOPIC;

EID: 33947588310     PISSN: 15268004     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-970048     Document Type: Review

References (17)

1. Bleyer WA. The clinical pharmacology of methotrexate: new applications of an old drug. Cancer 1978;41:36-51
2. Tanaka T, Hayashi H, Kutsuzawa T, Fujimoto S, Ichinoe K. Treatment of interstitial ectopic pregnancy with methotrexate: report of a successful case. Fertil Steril 1982;37: 851-852
3. Stovall TG, Ling FW, Buster JE. Outpatient chemotherapy of unruptured ectopic pregnancy. Fertil Steril 1989;51:435-438
4. Stovall TG, Ling FW, Gray LA. Single-dose methotrexate for treatment of ectopic pregnancy. Obstet Gynecol 1991; 77:754-757
5. Lipscomb GH, Bran D, McCord ML, Portera C, Ling FW. An analysis of 315 ectopic pregnancies treated with single-dose methotrexate. Am J Obstet Gynecol 1998;178: 1354-1358
6. Lipscomb GH, McCord ML, Huff G, Stovall TG, Ling FW. Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies. N Engl J Med 1999; 341:1874-1878
7. Vermesh M, Graczykowski JW, Sauer MV. Reevaluation of the role of culdocentesis in the management of ectopic pregnancy. Am J Obstet Gynecol 1990;162:411-413
8. Romero R, Copel JA, Kadar N, Jeanty P, Decherney A, Hobbins JC. Value of culdocentesis in the diagnosis of ectopic pregnancy. Obstet Gynecol 1985;65:519-522
9. Cartwright PS, Vaughn B, Tuttle D. Culdocentesis and ectopic pregnancy. J Reprod Med 1984;29:88-91
10. Brown DL, Felker RE, Stovall TG, Emerson DS, Ling FW. Serial endovaginal sonography of ectopic pregnancies treated with methotrexate. Obstet Gynecol 1991;77:406-409
11. Barnhart KT, Gosman G, Ashby R, Sammel M. The medical management of ectopic pregnancy: a meta-analysis comparing "single dose" and "multidose" regimens. Obstet Gynecol 2003;101:778-784
12. Lipscomb GH, Givens VA, Meyer NL, Bran D. Comparison of multidose and single-dose methotrexate protocols for the treatment of ectopic pregnancy. Am J Obstet Gynecol 2005; 192:1847-1848
13. Alleyassin A, Khademi A, Aghahosseini M, et al. Comparison of success rates in the medical management of ectopic pregnancy with single-dose and multiple-dose administration of methotrexate: a prospective, randomized clinical trial. Fertil Steril 2006;85:1661-1666
14. Lipscomb GH, Givens VA, Meyer ML, Bran D. Previous ectopic pregnancy as a risk factor for failure of systemic methotrexate therapy. Fertil Steril 2004;81:1221-1224
15. Stovall TG, Ling FW. Single-dose methotrexate: an expanded clinical trial. Am J Obstet Gynecol 1993;168: 1759
16. Lipscomb GH, Puckett KJ, Bran D, Ling FW. Management of separation pain after single-dose methotrexate therapy for ectopic pregnancy. Obstet Gynecol 1999;93: 590
17. Stovall TG, Ling FW. Expectant management of ectopic pregnancy. Obstet Gynecol Clin North Am 1991;18:135