Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 8, 2007, Pages 2281-2284

  Caldwell, John P ^a   Matasi, Julius J ^a   Zhang, Hongtao ^a   Fawzi, Ahmad ^a   Tulshian, Deen B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Agonist; Nociceptin; NOP receptor; Orphanin FQ

Indexed keywords

NOCICEPTIN RECEPTOR; PIPERIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; FEMALE; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ADMINISTRATION, ORAL; ANIMALS; COUGH; DRUG EVALUATION, PRECLINICAL; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); LIGANDS; PHARMACOKINETICS; PIPERIDINES; PROTEIN BINDING; RATS; RECEPTORS, OPIOID; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33947585045     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.069     Document Type: Article

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