Biochemical and pathological evaluation of albendazole/thalidomide co-therapy against eosinophilic meningitis or meningoencephalitis induced by Angiostrongylus cantonensis

Journal of Antimicrobial Chemotherapy

Volumn 59, Issue 2, 2007, Pages 264-276

  Chen, Ke Min ^a   Lai, Shih Chan ^a  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Angiostrongyliasis; Cytokines; Parasites; Proteinases; Thalidomide

Indexed keywords

ALBENDAZOLE; ALBUMIN; GELATINASE B; INTERLEUKIN 1BETA; INTERLEUKIN 5; THALIDOMIDE; TISSUE PLASMINOGEN ACTIVATOR; TUMOR NECROSIS FACTOR ALPHA; UROKINASE; ANTINEMATODAL AGENT; SERUM ALBUMIN;

ALBUMIN BLOOD LEVEL; ANGIOSTRONGYLUS CANTONENSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; EARLY INTERVENTION; ENZYME ACTIVITY; EOSINOPHIL COUNT; HISTOPATHOLOGY; LARVA; MALE; MENINGOENCEPHALITIS; MONOTHERAPY; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PROTEIN CEREBROSPINAL FLUID LEVEL; TREATMENT DURATION; TREATMENT PLANNING; ANIMAL; BAGG ALBINO MOUSE; BLOOD; BRAIN; CEREBROSPINAL FLUID; DISEASE MODEL; DRUG COMBINATION; ENZYMOLOGY; EOSINOPHILIA; GROWTH, DEVELOPMENT AND AGING; LEUKOCYTE COUNT; MENINGITIS; NEMATODIASIS; PARASITOLOGY; PATHOLOGY;

ALBENDAZOLE; ANGIOSTRONGYLUS CANTONENSIS; ANIMALS; ANTINEMATODAL AGENTS; BRAIN; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; EOSINOPHILIA; LEUKOCYTE COUNT; MALE; MENINGITIS; MENINGOENCEPHALITIS; MICE; MICE, INBRED BALB C; SERUM ALBUMIN; STRONGYLIDA INFECTIONS; THALIDOMIDE;

EID: 33947546045     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkl492     Document Type: Article

References (31)

1. Cheng CW, Sato Y, Chen ER. Epidemiological and clinical observations on eosinophilic meningitis and meningoencephalitis of children caused by infection with Angiostrongylus cantonensis in southern Taiwan. Ryukyu Med J 1984; 7: 1-9.
2. Tsai HC, Lee SS, Huang CK et al. Outbreak of eosinophilic meningitis associated with drinking raw vegetable juice in southern Taiwan. Am J Trop Med Hyg 2004; 71: 222-6.
3. Hou RF, Tu WC, Lee HH et al. Elevation of plasminogen activators in cerebrospinal fluid of mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. Int J Parasitol 2004; 34: 1355-46.
4. Lai SC, Twu JJ, Jiang ST et al. Induction of matrix metalloproteinase-9 in murine eosinophilic meningitis caused by Angiostrongylus cantonensis. Ann Trop Med Parasitol 2004; 98: 715-24.
5. Lee HH, Chou HL, Chen KM et al. Association of matrix-metalloproteinase-9 in eosinophilic meningitis of BALB/c mice caused by Angiostrongylus cantonensis. Parasitol Res 2004; 94 321-8.
6. Vorbrodt AW, Dobrogowska DH. Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: Electron microscopist's view. Brain Res Rev 2003; 42: 221-42.
7. Rosenberg GA, Kornfeld M, Estrada M et al. TIMP-2 reduces proteolytic opening of blood-brain barrier by type-IV collagenase. Brain 1992; 576: 203-7.
8. Leppert D, Leib SL, Grygar C et al. Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain border damage and neurological sequelae. Clin Infect Dis 2000; 31: 80-4.
9. Winkler F, Kastenbauer S, Koedel U et al. Role of the urokinase plasminogen activator system in patients with bacterial meningitis. Neurology 2002; 59: 1350-5.
10. Sugaya H, Aoki M, Abe T et al. Cytokine responses in mice infected with Angiostrongylus cantonensis. Parasitol Res 1997; 83: 10-15.
11. Sugaya H, Abe T, Yoshimura K. Eosinophils in the cerebrospinal fluid of mice infected with Angiostrongylus cantonensis are resistant to apoptosis. Int J Parasitol 2001; 31: 1649-58.
12. Beutler B, Cerami A. The biology of cachectin/TNF: A primary mediator of the host response. Ann Rev Immunol 1989; 7: 625-55.
13. Gearing AJ, Beckett P, Christodoulou M. Processing of tumour necrosis factor-alpha precursor by metalloproteinases. Nature 1994; 370 555-7.
14. Saren P, Welgus HG, Kovanen PT. TNF-alpha and IL-1 beta selectively induce expression of 92 kDa gelatinase by human macrophages. J Immunol 1996; 157: 4159-65.
15. Pugin J, Widmer MC, Kossodo S et al. Human neutrophils secrete gelatinase B in vitro and in vivo in response to endotoxin and proinflammatory mediators. Am J Respir Cell Mol Biol 1999; 20: 458-64.
16. Parsons JC, Grieve RB. Effect of egg dosage and host genotype on liver trapping in murine larval toxocariasis. J Parasitol 1990; 76 53-8.
17. Hwang KP, Chen ER. Larvicidal effect of albendazole against Angiostrongylus cantonensis in mice. Am J Trop Med Hyg 1988; 39: 191-5.
18. Venkatesan P. Albendazole. J Antimicrob Chemoth 1998; 41: 145-7.
19. Meierhofer C, Dunzendorfer S, Wedermann CJ. Theoretical basis for the activity of thalidomide. BioDrugs 2001; 15: 681-703.
20. Fu LM, Fu-Liu CS. Thalidomide and tuberculosis. Int J Tuberc Lung Dis 2002; 6: 569-72:
21. Chen KM, Lee HH, Lu KH et al. Association of matrix metalloproteinase-9 and Purkinje cell degeneration in mouse cerebellum caused by Angiostrongylus cantonensis. Int J Parasitol 2004; 34 1147-56.
22. James DM, Gilles HM. Human antiparasitic drug: Pharmacology and usage. New York: Wiley. 1985.
23. John DT, Martinez AJ. Animal model of human disease. Central nervous system infection with the nematode Angiostrongylus cantonensis. Animal model: Eosinophilic meningoencephalitis in mice infected with Angiostrongylus cantonensis. Am J Pathol 1975; 80: 345-8.
24. Yii CY. Clinical observations on eosinophilic meningitis and meningoencephalitis caused by Angiostrongylus cantonensis on Taiwan. Am J Trop Med Hyg 1976; 25: 233-49.
25. Pien FD, Pien BC. Angiostrongylus cantonensis eosinophilic meningitis. Int J Infect Dis 1999; 3: 161-3.
26. Paul R, Lorenzl S, Koedel U et al. Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis. Ann Neurol 1998; 44: 592-600.
27. Lai SC, Jiang ST, Chen KM et al. Efficacy of albendazole-GM6001 co-therapy against Angiostrongylus cantonensis induced parasitic meningitis in BALB/c mice. Acta Tropica 2005; 93: 267-73.
28. Nogueira AC, Neubert R, Helge H. Thalidomide and the immune system. 3. Simultaneous up- and down-regulation of different integrin receptors on human white blood cells. Life Sci 1994; 55: 77-92.
29. Sampaio EP, Samo EN, Galilly R. Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J Exp Med 1991; 173: 699-703.
30. Schoeman JF, Springer P, Ravenscroft A et al. Adjunctive thalidomide therapy of childhood tuberculous meningitis: Possible anti-inflammatory role. J Child Neurol 2000; 15: 497-503.
31. Sugaya H, Aoki M, Yoshida T et al. Eosinophils and intracranial worm recovery in interleukin-5 transgenic and interleukin-5 receptor α chain-knockout mice infected with Angiostrongylus cantonensis. Parasitol Res 1997; 83: 583-90.