Adipocyte differentiation of human marrow mesenchymal stem cells reduces the supporting capacity for hematopoietic progenitors but not for severe combined immunodeficiency repopulating cells

International Journal of Molecular Medicine

Volumn 19, Issue 3, 2007, Pages 387-392

  Ookura, Nobuhiko ^a   Fujimori, Yoshihiro ^b   Nishioka, Keisuke ^a   Kai, Shunro ^b   Hara, Hiroshi ^b   Ogawa, Hiroyasu ^a,b  

^a Hyogo College of Medicine   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Adipocytes; CD34; Hematopoietic progenitor cells; Mesenchymal stem cells; Severe combined immunodeficiency repopulating cells

Indexed keywords

CD34 ANTIGEN; CYTOKINE; GROWTH PROMOTOR; MESSENGER RNA;

ADIPOCYTE; ANIMAL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELL TRANSPLANTATION; COCULTURE; COMBINED IMMUNODEFICIENCY; CYTOLOGY; FEMALE; FETUS BLOOD; GENE EXPRESSION REGULATION; GENETICS; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNOLOGY; MESENCHYMAL STEM CELL; METABOLISM; MOUSE; MOUSE MUTANT; PATHOLOGY; TRANSPLANTATION; XENOGRAFT;

ADIPOCYTES; ANIMALS; ANTIGENS, CD34; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELL TRANSPLANTATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; FEMALE; FETAL BLOOD; GENE EXPRESSION REGULATION; GROWTH SUBSTANCES; HEMATOPOIETIC STEM CELLS; HUMANS; MESENCHYMAL STEM CELLS; MICE; MICE, SCID; RNA, MESSENGER; SEVERE COMBINED IMMUNODEFICIENCY; TRANSPLANTATION, HETEROLOGOUS;

EID: 33947543930     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.19.3.387     Document Type: Article

References (26)

1. Dorshkind K: Regulation of hematopoiesis by bone marrow stromal cells and their products. Annu Rev Immunol 8: 111-137, 1990. (Pubitemid 20135623)
2. Baines P, Mayani H, Bains M, Fisher J, Hoy T and Jacobs A: Enrichment of CD34 (My10)-positive myeloid and erythroid progenitors from human marrow and their growth in cultures supplemented with recombinant human granulocyte-macrophage colony-stimulating factor. Exp Hematol 16: 785-789, 1988.
3. Larochelle A, Vormoor J, Hanenberg H, Wang JC, Bhatia M, Lapidot T, Moritz T, Murdoch B, Xiao XL, Kato I, Williams DA and Dick JE: Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nat Med 2: 1329-1337, 1996. (Pubitemid 126157436)
4. Gimble JM, Robinson CE, Wu X and Kelly KA: The function of adipocytes in the bone marrow stroma: an update. Bone 19: 421-428, 1996. (Pubitemid 126745119)
5. Greenberger JS: Sensitivity of corticosteroid-dependent insulin-resistant lipogenesis in marrow preadipocytes of obese-diabetic (db/db) mice. Nature 275: 752-754, 1978.
6. Gartner S and Kaplan HS: Long-term culture of human bone marrow cells. Proc Natl Acad Sci USA 77: 4756-4759, 1980.
7. Kodama H, Sudo H, Koyama H, Kasai S and Yamamoto S: In vitro hemopoiesis within a microenvironment created by MC3T3-G2/PA6 preadipocytes. J Cell Physiol 118: 233-240, 1984.
8. Touw I and Lowenberg B: No stimulative effect of adipocytes on hematopoiesis in long-term human bone marrow cultures. Blood 61: 770-774, 1983. (Pubitemid 13115381)
9. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S and Marshak DR: Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-147, 1999. (Pubitemid 29282067)
10. Majumdar MK, Thiede MA, Mosca JD, Moorman M and Gerson SL: Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. J Cell Physiol 176: 57-66, 1998. (Pubitemid 28277195)
11. Majumdar MK, Thiede MA, Haynesworth SE, Bruder SP and Gerson SL: Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. J Hematother Stem Cell Res 9: 841-848, 2000.
12. Petzer AL, Zandstra PW, Piret JM and Eaves CJ: Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin. J Exp Med 183: 2551-2558, 1996.
13. Nishioka K, Fujimori Y, Hashimoto-Tamaoki T, Kai S, Qiu H, Kobayashi N, Tanaka N, Westerman KA, Leboulch P and Hara H: Immortalization of bone marrow-derived human mesenchymal stem cells by removable simian virus 40T antigen gene: analysis of the ability to support expansion of cord blood hematopoietic progenitor cells. Int J Oncol 23: 925-932, 2003.
14. Jaiswal N, Haynesworth SE, Caplan AI and Bruder SP: Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem 64: 295-312, 1997. (Pubitemid 27065443)
15. Mackay AM, Beck SC, Murphy JM, Barry FP, Chichester CO and Pittenger MF: Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow. Tissue Eng 4: 415-428, 1998. (Pubitemid 28553528)
16. Hara H, Kai S, Fushimi M, Taniwaki S, Okamoto T, Ohe Y, Fujita S, Noguchi K, Senba M, Hamano T, Kanamaru A and Nagai K: Pluripotent hemopoietic precursors in vitro (CFUMIX) in aplastic anemia. Exp Hematol 8: 1165-1171, 1980.
17. Fujimori Y, Hara H and Nagai K: Effect of lymphokine-activated killer cell fraction on the development of human hematopoietic progenitor cells. Cancer Res 48: 534-538, 1988. (Pubitemid 18056517)
18. Fujimori Y, Ogawa M, Clark SC and Dover GJ: Serum-free culture of enriched hematopoietic progenitors reflects physiologic levels of fetal hemoglobin biosynthesis. Blood 75: 1718-1722, 1990. (Pubitemid 20145762)
19. McNiece IK, Stewart FM, Deacon DM, Temeles DS, Zsebo KM, Clark SC and Quesenberry PJ: Detection of a human CFC with a high proliferative potential. Blood 74: 609-612, 1989. (Pubitemid 19208800)
20. Yoshino H, Ueda T, Kawahata M, Kobayashi K, Ebihara Y, Manabe A, Tanaka R, Ito M, Asano S, Nakahata T and Tsuji K: Natural killer cell depletion by anti-asialo GM1 antiserum treatment enhances human hematopoietic stem cell engraftment in NOD/Shi-scid mice. Bone Marrow Transplant 26: 1211-1216, 2000.
21. Becker M, Nitsche A, Neumann C, Aumann J, Junghahn I and Fichtner I: Sensitive PCR method for the detection and real-time quantification of human cells in xenotransplantation systems. Br J Cancer 87: 1328-1335, 2002. (Pubitemid 36009141)
22. Yokota T, Oritani K, Takahashi I, Ishikawa J, Matsuyama A, Ouchi N, Kihara S, Funahashi T, Tenner AJ, Tomiyama T and Matsuzawa Y: Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 96: 1723-1732, 2000. (Pubitemid 30661055)
23. Bhatia M, Bonnet D, Kapp U, Wang JC, Murdoch B and Dick JE: Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture. J Exp Med 186: 619-624, 1997. (Pubitemid 27360806)
24. Milner LA, Kopan R, Martin DI and Bernstein ID: A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors. Blood 83: 2057-2062, 1994.
25. Jones P, May G, Healy L, Brown J, Hoyne G, Delassus S and Enver T: Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells. Blood 92: 1505-1511, 1998. (Pubitemid 28406852)
26. Karanu FN, Murdoch B, Gallacher L, Wu DM, Koremoto M, Sakano S and Bhatia M: The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells. J Exp Med 192: 1365-1372, 2000.