Search for potential non-steroidal inhibitors of 17β-hydroxysteroid dehydrogenase (17β-HSD) in the treatment of hormone-dependent cancers

Letters in Drug Design and Discovery

Volumn 4, Issue 3, 2007, Pages 180-184

  Lota, Rupinder K ^a   Dhanani, Sachin ^a   Owen, Caroline P ^a   Ahmed, Sabbir ^a  

^a KINGSTON UNIVERSITY   (United Kingdom)

Author keywords

17 hydroxysteroid dehydrogenase; Biphenyl ketones; Enzyme inhibition; Inhibition; Type 3

Indexed keywords

7 HYDROXYFLAVONE; BAICALEIN; BIPHENYL KETONE DERIVATIVE; ENZYME INHIBITOR; KETONE DERIVATIVE; TESTOSTERONE 17BETA DEHYDROGENASE; TESTOSTERONE 17BETA DEHYDROGENASE 1; TESTOSTERONE 17BETA DEHYDROGENASE 3; UNCLASSIFIED DRUG;

ARTICLE; CANCER CHEMOTHERAPY; DRUG STRUCTURE; ENZYME INHIBITION; HORMONE ACTION; PRIORITY JOURNAL; SYNTHESIS;

EID: 33947505322     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018007780077417     Document Type: Article

References (9)

1. Poirier, D. Curr. Med. Chem., 2003, 10, 453-77.
2. Bratoeff, E.; Ramírez, E.; Murillo, E.; Flores, G.; Cabeza, M. Curr. Med. Chem., 1999, 6, 1107-23.
3. Owen, C. P.; Ahmed, S. Biochem. Biophys. Res. Comm., 2004, 318, 131-4.
4. Le Lain, R.; Nicholls, P. J.; Smith, H. J.; Maharlouie, F. H. J. Pharm. Pharmacol., 1999, 51 (Suppl.), 23-23.
5. Ahmed, S.; Owen, C.; James, K.; Patel, C. K.; Patel, M. Bioorg. Med. Chem. Lett., 2001, 11, 2525-28.
6. Ahmed, S.; Owen, C.; James, K.; Patel, C. K.; Patel, M. J. Steroid Biochem. Mol. Biol., 2002, 80, 419-27.
7. Takebayashi, M.; Ibata, T.; Ueda, K. Bull. Chem. Soc. Jpn., 1970, 43, 1500-5.
8. Hartung, W. H.; Munch, J. C.; Crossley, F. S. J. Amer. Chem. Soc., 1935, 57, 1091-93.
9. Lota, R.; Dhanani, S.; Owen, C. P.; Ahmed, S. Bioorg. Med. Chem. Lett., 2006, 16, 4519-22.