Muscle trauma and immune activation after a downhill marathon (Tyrolean Speed Marathon)

Pteridines

Volumn 17, Issue 4, 2006, Pages 121-128

  Schobersberger, Wolfgang ^a   Sumann, Guenther ^b   Mittermayr, Markus ^b   Griesmacher, Andrea ^a   Falkensammer, Gerda ^c   Greie, Sven ^a   Schobersberger, Beatrix ^a   Hoffmann, Georg ^a   Fuchs, Dietmar ^b   Koller, Arnold ^d  

^a UNIVERSITY FOR HEALTH SCIENCES   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c TILAK   (Austria)

^d Department of Sports Medicine ^*  (Austria)

Author keywords

Eccentric exercise; Immune activation; Muscle damage; Neopterin; Troponin

Indexed keywords

C REACTIVE PROTEIN; CREATINE KINASE; MYOGLOBIN; NEOPTERIN; TROPONIN;

ADULT; ARTICLE; BLOOD SAMPLING; CELLULAR IMMUNITY; CONTROLLED STUDY; DYNAMOMETRY; EXERCISE; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LEUKOCYTE COUNT; MALE; MARATHON RUNNER; MUSCLE INJURY; MUSCLE ISOMETRIC CONTRACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; SKELETAL MUSCLE;

EID: 33947394878     PISSN: 09334807     EISSN: 21954720     Source Type: Journal    
DOI: 10.1515/pteridines.2006.17.4.121     Document Type: Article

References (32)

1. Pedersen BK, Hoffmann-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev 2000; 80: 1055-1081.
2. Malm Ch. Exercise immunology. The current state of man and mouse. Sports Med 2004; 34: 555-566.
3. Matthews CE, Ockene IS, Freedson PS, et al. Moderate to vigorous physical activity and risk of upper-respiratory tract infection. Med Sci Sports Exerc 2002; 34: 1242-1248.
4. Nieman DC, Johanssen LM, Lee JW, Arabatzis K. Infectious episodes in runners before and after the Los Angeles Marathon. J Sports Med Phys Fitness 1990; 30: 316-328.
5. Nieman DC. Is infection risk linked to exercise workload? Med Sci Sports Exerc 2000; 32 (Suppl.): 406-411.
6. Kaspasis Ch, Thompson PD. The effects of physical activity on serum C-reactive protein and inflammatory markers. J Am Coll Cardiol 2005; 45: 1563-1569.
7. Petersen AM, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol 2005; 98: 1154-1162.
8. Hoffmann G, Schobersberger W. Neopterin: a mediator of the cellular immune system. Pteridines 2004; 15: 107-112.
9. Tilz GP, Domej W, Diez-Ruit A, et al. Increased immune activation during and after physical exercise. Immunbiology 1993; 188; 194-202.
10. Deetjen Ch, Mair J, Herold M, et al. Time course of neopterin and cytokines after an extreme bicycle race at moderate altitude. Pteridines 1997; 8: 195-200.
11. Sprenger H, Jacobs C, Nain M, et al. Enhanced release of cytokines, interleukin-2 receptors, and neopterin after long-distance running. Clin Imunol Immunpathol 1992; 63: 188-195.
12. Gunga HC, Machotta A, Schobersberger W, et al. Neopterin, IgG, IgA, IgM, and plasma volume changes during long-distance running. Pteridines 2002; 13: 15-20.
13. Close GL, Kayani A, Vasilaki A, McArdle A. Skeletal muscle damage with exercise and aging. Sports Med 2005; 35: 413-427.
14. Fehrenbach E, Schneider ME. Trauma-induced systemic inflammatory response versus exercise-induced immunmodulatory effects. Sports Med 2006; 36: 373-84.
15. Sorichter S, Mair J, Koller A, et al. Skeletal troponin I as a marker of exercise-induced muscle damage. J Appl Physiol 1997; 83: 1076-82.
16. Schobersberger W, Wirleitner B, Puschendorf B, et al. Influence of an ultramarathon race at moderate altitude on coagulation and fibrinolysis. Fibrinolysis 1996; 10: 37-42.
17. Malm C, Sjödin TLB, Sjöberg B, et al. Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running. J Physiol 2004; 556: 983-1000.
18. Van Beaumont W, Underkofler S, van Beaumont S. Erythrocyte volume, plasma volume, and acid-base changes in exercise and heat dehydration. J Appl Physiol 1981; 50: 1255-1262.
19. Koller A, Sumann G, Schobersberger W, Hoertnagl H, Haid C. Decrease in eccentric hamstring strength in runners in the Tirol Speed Marathon. Br J Sports Med 2006; 40: 850-852.
20. Rokos H, Rokos K, Kunze ROF. Variations of neopterine, dihydroneopterine and immunological parameters during physical exercise. In: Unconjugated Pterins and Related Biogenic Amines. Berlin: Walter de Gruyter & Co 1987.
21. Dufaux B, Order U. Plasma elastase-alpha 1-antitrypsin, neopterin, tumor necrosis factor, and soluble interleukin-2 receptor after prolonged exercise. Int J Sports Med 1989; 10: 434-438.
22. Schobersberger W, Hobisch-Hagen P, Fries D, et al. Increase in immune activation, vascular endothelial growth factor and erythropoietin after an ultramarathon run at moderate altitude. Immunbiology 1999/2000; 201:611-620.
23. Margaritis I, Tessier F, Richard MJ, Marconnet P. No evidence of oxidative stress after a triathlon race in highly trained competitors. Int J Sports Med 1997; 18: 186-190.
24. Smith JA, Telford RD, Baker MS. Cytokine immunoreactivity in plasma does not change after moderate endurance exercise. Int J Sports Med 1990; 11: 179-187.
25. Gmunder FK, Joller PW, Joller-Jemelka HI, et al. Effect of herbal yeast food supplement and long-distance running on immunological parameters. Br J Sports Med 1990; 24: 103-112.
26. Hortobagyi T, Houmard J, Fraser D. Normal forces and myofibrillar disruption after repeated eccentric exercise. J Appl Physiol 1996; 80: 1006-13.
27. Malm C, Lenkei R, Sjödin B. Effects of eccentric exercise on the immune system in men. J Appl Physiol 1999; 86: 461-8.
28. Rifai N, Douglas PS, O'Toole M, Rimm E, Ginsburg GS. Cardiac troponin T and I, electrocardiographic wall motion analyses, and ejection fraction in athletes participating in the Hawaii ironman triathlon. Am J Cardiol 1999; 83: 1085-1089.
29. Siegel AJ, Lewandrowski EL, Chun KY, et al. Changes in cardiac markers including B-natriuretic peptide in runners after the Boston Marathon. Am J Cardiol 2001; 88: 920-923.
30. Scharhag J, Herrmann M, Urhausen A, et al. Independent elevations of N-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise. Am Heart J 2005; 150: 1128-1134.
31. Koller A. Exercise-induced increases in cardiac troponins and prothrombotic markers. Med Sci Sports Exerc 2003; 35: 444-448.
32. Ohba H, Takada H, Musha H, et al. Effects of prolonged strenuous exercise on plasma levels of atrial natriuretic peptide and brain natriuretic peptide in healthy men. Am Heart J 2001; 141: 751-758.