FLUOXETINE modifies the expression of serotonergic markers in a differentiation-dependent fashion in the mesencephalic neural cell line A1 mes c-myc

Brain Research

Volumn 1143, Issue 1, 2007, Pages 1-10

  Di Lieto, Antonio ^a   Leo, Damiana ^a   Volpicelli, Floriana ^a   di Porzio, Umberto ^a   Colucci D'Amato, Luca ^a,b  

^a INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

5 HT; SERT; TPH1; TPH2; VMAT2

Indexed keywords

CITALOPRAM; CYCLIC AMP; FLUOXETINE; MESSENGER RNA; SEROTONIN; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 2;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; BRAIN NERVE CELL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; FIBROBLAST; GENE EXPRESSION; MENTAL DISEASE; MESENCEPHALON; MOUSE; NERVE CELL; NERVE CELL DIFFERENTIATION; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANALYSIS OF VARIANCE; ANIMALS; CELL COUNT; CELL DIFFERENTIATION; CELL LINE; CITALOPRAM; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; FLUOXETINE; GENE EXPRESSION; MESENCEPHALON; MICE; NEURONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; TIME FACTORS; TRYPTOPHAN HYDROXYLASE; VESICULAR MONOAMINE TRANSPORT PROTEINS;

EID: 33947331255     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.01.076     Document Type: Article

References (37)

1. Bach-Mizrachi H., Underwood M.D., Kassir S.A., Bakalian M.J., Sibille E., Tamir H., Mann J.J., and Arango V. Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. Neuropsychopharmacology 31 (2006) 814-824
2. Baik S.Y., Jung K.H., Choi M.R., Yang B.H., Kim S.H., Lee J.S., Oh D.Y., Choi I.G., Chung H., and Chai Y.G. FLUOXETINE-induced up-regulation of 14-3-3zeta and tryptophan hydroxylase levels in RBL-2H3 cells. Neurosci. Lett. 374 (2005) 53-57
3. Bell C., Abrams J., and Nutt D. Tryptophan depletion and its implications for psychiatry. Br. J. Psychiatry 178 (2001) 399-405
4. Bezchlibnyk-Butler K., Aleksic I., and Kennedy S.H. Citalopram: a review of pharmacological and clinical effects. J. Psychiatry Neurosci. 25 (2000) 241-254
5. Castren E. Is mood chemistry?. Nat. Rev., Neurosci. 6 (2005) 241-246
6. Chen G., Hasanat K.A., Bebchuk J.M., Moore G.J., Glitz D., and Manji H.K. Regulation of signal transduction pathways and gene expression by mood stabilizers and antidepressants. Psychosom. Med. 61 (1999) 599-617
7. Clark J.A., Pai L.Y., Flick R.B., and Rohrer S.P. Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus. Biol. Psychiatry 57 (2005) 943-946
8. Colucci-D'Amato G.L., Tino A., Pernas-Alonso R., Ffrench-Mullen J.M., and di Porzio U. Neuronal and glial properties coexist in a novel mouse CNS immortalized cell line. Exp. Cell Res. 252 (1999) 383-391
9. De Luca V., Likhodi O., Van Tol H.H., Kennedy J.L., and Wong A.H. Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophrenia. Psychopharmacology (Berl) 183 (2005) 378-382
10. Dygalo N.N., Shishkina G.T., Kalinina T.S., Yudina A.M., and Ovchinnikova E.S. Effect of repeated treatment with FLUOXETINE on tryptophan hydroxylase-2 gene expression in the rat brainstem. Pharmacol. Biochem. Behav. 85 (2006) 220-227
11. Fuchs E., Czeh B., Kole M.H., Michaelis T., and Lucassen P.J. Alterations of neuroplasticity in depression: the hippocampus and beyond. Eur. Neuropsychopharmacol. 5 (2004) S481-S490
12. Fujioka T., Fujioka A., and Duman R.S. Activation of cAMP signaling facilitates the morphological maturation of newborn neurons in adult hippocampus. J. Neurosci. 24 (2004) 319-328
13. Geddes J.R., Freemantle N., Mason J., Eccles M.P., and Boynton J. SSRIs versus other antidepressants for depressive disorder. Cochrane Database Syst. Rev. 2 (2000) (CD001851)
14. Hansson S.R., Mezey E., and Hoffman B.J. Serotonin transporter messenger RNA in the developing rat brain: early expression in serotonergic neurons and transient expression in non-serotonergic neurons. Neuroscience 83 (1998) 1185-1201
15. Hiroi R., McDevitt R.A., and Neumaier J.F. Estrogen selectively increases hydroxylase-2 mRNA expression in distinct subregions of rat midbrain raphe nucleus: association between gene expression and anxiety behavior in the open field. Biol. Psychiatry 60 (2006) 288-295
16. Kim S.W., Park S.Y., and Hwang O. Up-regulation of tryptophan hydroxylase expression and serotonin synthesis by sertraline. Mol. Pharmacol. 61 (2002) 778-785
17. Lidow M.S., Goldman-Rakic P.S., Gallagher D.W., and Rakic P.J. Quantitative autoradiographic mapping of serotonin 5-HT1 and 5-HT2 receptors and uptake sites in the neocortex of the rhesus monkey. J. Comp. Neurol. 280 (1989) 27-42
18. Maeda T., Fujimiya M., Kitahama K., Imai H., and Kimura H. Serotonin neurons and their physiological roles. Arch. Histol. Cytol. 52S (1989) 113-120
19. Malberg J.E., Eisch A.J., Nestler E.J., and Duman R.S. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 20 (2000) 9104-9110
20. Malek Z.S., Dardente H., Pevet P., and Raison S. Tissue-specific expression of tryptophan hydroxylase mRNAs in the rat midbrain: anatomical evidence and daily profiles. Eur. J. Neurosci. 22 (2005) 895-901
21. Manev H., Uz T., Smalheiser N.R., and Manev R. Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro. Eur. J. Pharmacol. 411 (2001) 67-70
22. McKinney J., Knappskog P.M., and Haavik J. Different properties of the central and peripheral forms of human tryptophan hydroxylase. J. Neurochem. 92 (2005) 311-320
23. Mossner R., Walitza S., Geller F., Scherag A., Gutknecht L., Jacob C., Bogusch L., Remschmidt H., Simons M., Herpertz-Dahlmann B., Fleischhaker C., Schulz E., Warnke A., Hinney A., Wewetzer C., and Lesch K.P. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder. Int. J. Neuropsychopharmacol. 7 (2005) 1-6
24. Nakamura K., Sugawara Y., Sawabe K., Ohashi A., Tsurui H., Xiu Y., Ohtsuji M., Lin Q.S., Nishimura H., Hasegawa H., and Hirose S. Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. J. Neurosci. 26 (2006) 530-534
25. Patel P.D., Pontrello C., and Burke S. Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland. Biol. Psychiatry 55 (2004) 428-433
26. Pernas-Alonso R., Morelli F., di Porzio U., and Perrone-Capano C. Multiplex semi-quantitative reverse transcriptase-polymerase chain reaction of low abundance neuronal mRNAs. Brain. Res. Brain Res. Protoc. 4 (1999) 395-406
27. Peters E.J., Slager S.L., Mc Grath P.J., Knowles J.A., and Hamilton S.P. Investigation of serotonin-related genes in antidepressant response. Mol. Psychiatry 9 (2004) 879-889
28. Santarelli L., Saxe M., Gross C., Surget A., Battaglia F., Dulawa S., Weisstaub N., Lee J., Duman R., Arancio O., Belzung C., and Hen R. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301 (2003) 805-809
29. Sato T.L., Jequier E., Lovenberg W., and Sjoerdsma A. Characterization of a tryptophan hydroxylating enzyme from malignant mouse mast cell. Eur. J. Pharmacol. 1 (1967) 18-25
30. Spurlock G., Buckland P., O'Donovan M., and McGuffin P. Lack of effect of antidepressant drugs on the levels of mRNAs encoding serotonergic receptors, synthetic enzymes and 5HT transporter. Neuropharmacology 33 (1994) 433-440
31. Walitza S., Renner T.J., Dempfle A., Konrad K., Wewetzer Ch., Halbach A., Herpertz-Dahlmann B., Remschmidt H., Smidt J., Linder M., Flierl L., Knolker U., Friedel S., Schafer H., Gross C., Hebebrand J., Warnke A., and Lesch K.P. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Mol. Psychiatry 10 (2005) 1126-1132
32. Walther D.J., Peter J.U., Bashammakh S., Hortnagl H., Voits M., Fink H., and Bader M. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299 (2003) 76
33. Weihe E., and Eiden L.E. Chemical neuroanatomy of the vesicular amine transporters. FASEB J. 14 (2000) 2435-2449
34. Wong M.L., and Licinio J. Research and treatment approaches to depression. Nat. Rev., Neurosci. 2 (2001) 343-351
35. Wong D.T., Perry K.W., and Bymaster F.P. Case history: the discovery of FLUOXETINE hydrochloride (Prozac). Nat. Rev., Drug Discov. 4 (2005) 764-774
36. Zhang X., Gainetdinov R.R., Beaulieu J.M., Sotnikova T.D., Burch L.H., Williams R.B., Schwartz D.A., Krishnan K.R., and Caron M.G. Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45 (2005) 11-16
37. Zill P., Buttner A., Eisenmenger W., Moller H.J., Bondy B., and Ackenheil M. Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biol. Psychiatry 56 (2004) 581-586