메뉴 건너뛰기




Volumn 17, Issue 3, 2007, Pages 264-270

Downregulation of NFAT5 by RNA interference reduces monoclonal antibody productivity of hybridoma cells

Author keywords

Antibody formation; Hybridomas; NFAT transcription factors; RNA interference

Indexed keywords

HYPERTONIC SOLUTION; MONOCLONAL ANTIBODY; NFAT5 PROTEIN, MOUSE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 33947326615     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2007.3     Document Type: Article
Times cited : (5)

References (28)
  • 1
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975; 256:495-497.
    • (1975) Nature , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 2
    • 0037083193 scopus 로고    scopus 로고
    • Characterization of hybridoma cell responses to elevated pCO(2) and osmolality: Intracellular pH, cell size, apoptosis, and metabolism
    • deZengotita VM, Schmelzer AE, Miller WM. Characterization of hybridoma cell responses to elevated pCO(2) and osmolality: intracellular pH, cell size, apoptosis, and metabolism. Biotechnol Bioeng 2002; 77:369-380.
    • (2002) Biotechnol Bioeng , vol.77 , pp. 369-380
    • deZengotita, V.M.1    Schmelzer, A.E.2    Miller, W.M.3
  • 3
    • 0035947512 scopus 로고    scopus 로고
    • Rapamycin reduces hybridoma cell death and enhances monoclonal antibody production
    • Balcarcel RR, Stephanopoulos G. Rapamycin reduces hybridoma cell death and enhances monoclonal antibody production. Biotechnol Bioeng 2001; 76:1-10.
    • (2001) Biotechnol Bioeng , vol.76 , pp. 1-10
    • Balcarcel, R.R.1    Stephanopoulos, G.2
  • 4
    • 18944365890 scopus 로고    scopus 로고
    • The influence of the chemical composition of cell culture material on the growth and antibody production of hybridoma cells
    • Heilmann K, Groth T, Behrsing O, et al. The influence of the chemical composition of cell culture material on the growth and antibody production of hybridoma cells. J Biotechnol 2005; 115:291-301.
    • (2005) J Biotechnol , vol.115 , pp. 291-301
    • Heilmann, K.1    Groth, T.2    Behrsing, O.3
  • 6
    • 0009668445 scopus 로고    scopus 로고
    • Hyperosmotic pressure enhances immunoglobulin transcription rates and secretion rates of KR12H-2 transfectoma
    • Lee MS, Lee GM. Hyperosmotic pressure enhances immunoglobulin transcription rates and secretion rates of KR12H-2 transfectoma. Biotechnol Bioeng 2000; 68:260-268.
    • (2000) Biotechnol Bioeng , vol.68 , pp. 260-268
    • Lee, M.S.1    Lee, G.M.2
  • 7
    • 1842814059 scopus 로고    scopus 로고
    • Hyper-osmotic stress in murine hybridoma cells: Effects on antibody transcription, translation, posttranslational processing, and the cell cycle
    • Sun Z, Zhou R, Liang S, McNeeley KM, Sharfstein ST. Hyper-osmotic stress in murine hybridoma cells: effects on antibody transcription, translation, posttranslational processing, and the cell cycle. Biotechnol Prog 2004; 20:576-589.
    • (2004) Biotechnol Prog , vol.20 , pp. 576-589
    • Sun, Z.1    Zhou, R.2    Liang, S.3    McNeeley, K.M.4    Sharfstein, S.T.5
  • 8
    • 30944463410 scopus 로고    scopus 로고
    • Genome-wide analysis of the transeriptional response of murine hybridomas to osmotic shock
    • Shen D, Sharfstein ST. Genome-wide analysis of the transeriptional response of murine hybridomas to osmotic shock. Biotechnol Bioeng 2006; 93:132-145.
    • (2006) Biotechnol Bioeng , vol.93 , pp. 132-145
    • Shen, D.1    Sharfstein, S.T.2
  • 9
    • 13044250453 scopus 로고    scopus 로고
    • Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity
    • Miyakawa H, Woo SK, Dahl SC, Handler JS, Kwon HM. Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity. Proc Natl Acad Sci USA 1999; 96:2538-2542.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2538-2542
    • Miyakawa, H.1    Woo, S.K.2    Dahl, S.C.3    Handler, J.S.4    Kwon, H.M.5
  • 10
    • 0030953922 scopus 로고    scopus 로고
    • Regulation of gene expression by hypertonicity
    • Burg MB, Kwon ED, Kultz D. Regulation of gene expression by hypertonicity. Annu Rev Physiol 1997; 59:437-455.
    • (1997) Annu Rev Physiol , vol.59 , pp. 437-455
    • Burg, M.B.1    Kwon, E.D.2    Kultz, D.3
  • 11
    • 28444498126 scopus 로고    scopus 로고
    • Intracellular water homeostasis and the mammalian cellular osmotic stress response
    • Ho SN. Intracellular water homeostasis and the mammalian cellular osmotic stress response. J Cell Physiol 2006; 206:9-15.
    • (2006) J Cell Physiol , vol.206 , pp. 9-15
    • Ho, S.N.1
  • 13
    • 24944568433 scopus 로고    scopus 로고
    • High NaCl increases TonEBP/OREBP mRNA and protein by stabilizing its mRNA
    • Cai Q, Ferraris JD, Burg MB. High NaCl increases TonEBP/OREBP mRNA and protein by stabilizing its mRNA. Am J Physiol Renal Physiol 2005; 289:F803-F807.
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Cai, Q.1    Ferraris, J.D.2    Burg, M.B.3
  • 14
    • 0442307916 scopus 로고    scopus 로고
    • Transcription factor tonicity-responsive enhancer-binding protein (TonEBP) which transactivates osmoprotective genes is expressed and upregulated following acute systemic hypertonicity in neurons in brain
    • Loyher ML, Mutin M, Woo SK, Kwon HM, Tappaz ML. Transcription factor tonicity-responsive enhancer-binding protein (TonEBP) which transactivates osmoprotective genes is expressed and upregulated following acute systemic hypertonicity in neurons in brain. Neurosciencc 2004; 124:89-104.
    • (2004) Neurosciencc , vol.124 , pp. 89-104
    • Loyher, M.L.1    Mutin, M.2    Woo, S.K.3    Kwon, H.M.4    Tappaz, M.L.5
  • 17
    • 0033594887 scopus 로고    scopus 로고
    • NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun
    • Lopez-Rodriguez C, Aramburu J, RakemanAS, Rao A. NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun. Proc Natl Acad Sci USA 1999; 96:7214-7219.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7214-7219
    • Lopez-Rodriguez, C.1    Aramburu, J.2    Rakeman, A.S.3    Rao, A.4
  • 18
    • 0034671865 scopus 로고    scopus 로고
    • Arabidopsis transcription factors: Genome-wide comparative analysis among eukaryotes
    • Riechmann JL, Heard J, Martin G, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science 2000; 290:2105-2110.
    • (2000) Science , vol.290 , pp. 2105-2110
    • Riechmann, J.L.1    Heard, J.2    Martin, G.3
  • 19
    • 0000279175 scopus 로고    scopus 로고
    • Bidirectional regulation of tonicity-responsive enhancer binding protein in response to changes in tonicity
    • Woo SK, Dahl SC, Handler JS, Kwon HM. Bidirectional regulation of tonicity-responsive enhancer binding protein in response to changes in tonicity. Am J Physiol Renal Physiol 2000; 278: F1006-F1012.
    • (2000) Am J Physiol Renal Physiol , vol.278
    • Woo, S.K.1    Dahl, S.C.2    Handler, J.S.3    Kwon, H.M.4
  • 20
    • 0033756163 scopus 로고    scopus 로고
    • A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster
    • Huang AM, Rubin GM. A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster. Genetics 2000; 156:1219-1230.
    • (2000) Genetics , vol.156 , pp. 1219-1230
    • Huang, A.M.1    Rubin, G.M.2
  • 21
    • 3242674944 scopus 로고    scopus 로고
    • NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment
    • Go WY, Liu XB, Roti MA, Liu F, Ho SN. NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment. Proc Natl Acad Sci USA 2004; 101:10673-10678.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10673-10678
    • Go, W.Y.1    Liu, X.B.2    Roti, M.A.3    Liu, F.4    Ho, S.N.5
  • 22
    • 0028340944 scopus 로고
    • Hypertonic saline enhances cellular immune function
    • Junger WG, Liu FC, Loomis WH, Hoyt DB. Hypertonic saline enhances cellular immune function. Circ Shock 1994; 42:190-196.
    • (1994) Circ Shock , vol.42 , pp. 190-196
    • Junger, W.G.1    Liu, F.C.2    Loomis, W.H.3    Hoyt, D.B.4
  • 23
    • 0029585124 scopus 로고
    • Osmotic regulation of cytokine synthesis in vitro
    • Shapiro L, Dinarello CA. Osmotic regulation of cytokine synthesis in vitro. Proc Natl Acad Sci USA 1995; 92:12230-12234.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 12230-12234
    • Shapiro, L.1    Dinarello, C.A.2
  • 24
    • 20644466433 scopus 로고    scopus 로고
    • NFAT proteins: Key regulators of T-cell development and function
    • Macian F. NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol 2005; 5:472-484.
    • (2005) Nat Rev Immunol , vol.5 , pp. 472-484
    • Macian, F.1
  • 25
    • 0034907525 scopus 로고    scopus 로고
    • Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress
    • Lopez-Rodriguez C, Aramburu J, Jin L, Rakeman AS, Michino M, Rao A. Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress. Immunity 2001; 15:47-58.
    • (2001) Immunity , vol.15 , pp. 47-58
    • Lopez-Rodriguez, C.1    Aramburu, J.2    Jin, L.3    Rakeman, A.S.4    Michino, M.5    Rao, A.6
  • 26
    • 0038475924 scopus 로고    scopus 로고
    • Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation
    • Loomis WH, Namiki S, Ostrom RS, Insel PA, Junger WG. Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation. J Biol Chem 2003; 278:4590-4596.
    • (2003) J Biol Chem , vol.278 , pp. 4590-4596
    • Loomis, W.H.1    Namiki, S.2    Ostrom, R.S.3    Insel, P.A.4    Junger, W.G.5
  • 27
    • 0037111409 scopus 로고    scopus 로고
    • The osmoprotective function of the NFAT5 transcription factor in T cell development and activation
    • Trama J, Go WY, Ho SN. The osmoprotective function of the NFAT5 transcription factor in T cell development and activation. J Immunol 2002; 169:5477-5488.
    • (2002) J Immunol , vol.169 , pp. 5477-5488
    • Trama, J.1    Go, W.Y.2    Ho, S.N.3
  • 28
    • 33947323652 scopus 로고    scopus 로고
    • Lymphocyte responses - NFAT5: Helping out in stressful times
    • Bird L. Lymphocyte responses - NFAT5: helping out in stressful times. Nat Rev Immunol 2004; 4:581.
    • (2004) Nat Rev Immunol , vol.4 , pp. 581
    • Bird, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.