Dynamic Collision-Induced Dissociation (DCID) in a Quadrupole Ion Trap Using a Two-Frequency Excitation Waveform: I. Effects of Excitation Frequency and Phase Angle

Journal of the American Society for Mass Spectrometry

Volumn 18, Issue 4, 2007, Pages 749-761

  Laskay, Ünige A ^a   Hyland, Jennifer J ^b   Jackson, Glen P ^a  

^a OHIO UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLISION-INDUCED DISSOCIATION (CID); END-CAP ELECTRODES; EXCITATION WAVEFORM; QUADRUPOLE ION TRAP (QIT);

DISSOCIATION; ELECTRODES; EXCITATION ENERGY; RESONANCE; WAVEFORM ANALYSIS;

ELECTRON TRAPS;

BENZENE DERIVATIVE; ION; N BUTYLBENZENE; UNCLASSIFIED DRUG;

ARTICLE; COLLISIONALLY ACTIVATED DISSOCIATION; CORRELATION ANALYSIS; ELECTRODE; ENERGY TRANSFER; HEATING; ION TRAP MASS SPECTROMETRY; MOLECULE; THERMOMETER; TUNING CURVE; WAVEFORM;

EID: 33947326571     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2006.12.008     Document Type: Article

References (45)

1. Steiner V., Beaugrand C., Liere P., and Tabet J.-C. Influence of Trapping Parameters on Ion Injection and Dissociation Efficiencies in a Quadrupole Mass Filter Ion Trap Tandem Instrument. J. Mass Spectrom. 34 (1999) 511-520
2. Doroshenko V.M., and Cotter R.J. Injection of Externally Generated Ions into an Increasing Trapping Field of a Quadrupole Ion Trap Mass Spectrometer. J. Mass Spectrom. 32 (1997) 602-615
3. Goeringer D.E., Asano K.G., McLuckey S.A., Hoekman D., and Stiller S.W. Filtered Noise Field Signals for Mass-selective Accumulation of Externally Formed Ions in a Quadrupole Ion Trap. Anal. Chem. 66 (1994) 313-318
4. Sarurkar V.A., and Menon A.G. Vector Summed Sine Wave Tailored Waveforms for Dipolar Excitation of Ions in Paul Trap Mass Spectrometers. Rapid Commun. Mass Spectrom. 13 (1999) 469-473
5. Louris J.N., Cooks R.G., Syka J.E.P., Kelley P.E., Stafford G.C., and Todd J.F.J. Instrumentation, Applications, and Energy Deposition in Quadrupole Ion-Trap Tandem Mass-Spectrometry. Anal. Chem. 59 (1987) 1677-1685
6. Splendore M., Lausevic M., Lausevic Z., and March R.E. Resonant Excitation and/or Ejection of Ions Subjected to DC and RF Fields in a Commercial Quadrupole Ion Trap. Rapid Commun. Mass Spectrom. 11 (1997) 228-233
7. Splendore M., Marquette E., Oppenheimer J., Huston C., and Wells G. A New Ion Ejection Method Employing an Asymmetric Trapping Field to Improve the Mass Scanning Performance of an Electrodynamic Ion Trap. Int. J. Mass Spectrom. 191 (1999) 129-143
8. McClellan J.E., Quarmby S.T., and Yost R.A. Parent and Neutral Loss Monitoring on a Quadrupole Ion Trap Mass Spectrometer: Screening of Acylcarnitines in Complex Mixtures. Anal. Chem. 74 (2002) 5799-5806
9. Goeringer D.E., Whitten W.B., Ramsey J.M., McLuckey S.A., and Glish G.L. Theory of High-resolution Mass-Spectrometry Achieved via Resonance Ejection in the Quadrupole Ion Trap. Anal. Chem. 64 (1992) 1434-1439
10. Hao C.Y., and March R.E. A Survey of Recent Research Activity in Quadrupole Ion Trap Mass Spectrometry. Int. J. Mass Spectrom. 212 (2001) 337-357
11. Cox K.A., Williams J.D., Cooks R.G., and Kaiser R.E. Quadrupole Ion Trap Mass-Spectrometry-Current Applications and Future Directions for Peptide Analysis. Biol. Mass Spectrom. 21 (1992) 226-241
12. Fulford J.E., Hoa D.N., Hughes R.J., March R.E., Bonner R.F., and Wong G.J. Radio-Frequency Mass Selective Excitation and Resonant Ejection of Ions in a 3-Dimensional Quadrupole Ion Trap. J. Vac. Sci. Technol. 17 (1980) 829-835
13. Goeringer D.E., and McLuckey S.A. Evolution of Ion Internal Energy during Collisional Excitation in the Paul Ion Trap: A Stochastic Approach. J. Chem. Phys. 104 (1996) 2214-2221
14. McLuckey S.A. Principles of Collisional Activation in Analytical Mass-Spectrometry. J. Am. Soc. Mass Spectrom. 3 (1992) 599-614
15. Lammert S.A., and Cooks R.G. Pulsed Axial Activation in the Ion Trap-A New Method for Performing Tandem Mass-Spectroscopy (MS/MS). Rapid Commun. Mass Spectrom. 6 (1992) 528-530
16. Cunningham C., Glish G.L., and Burinsky D.J. High Amplitude Short Time Excitation: A Method to Form and Detect Low Mass Product Ions in a Quadrupole Ion Trap Mass Spectrometer. J. Am. Soc. Mass Spectrom. 17 (2006) 81-84
17. Murrell J., Despeyroux D., Lammert S.A., Stephenson J.L., and Goeringer D.E. "Fast Excitation" CID in a Quadrupole Ion Trap Mass Spectrometer. J. Am. Soc. Mass Spectrom. 14 (2003) 785-789
18. March R.E., and Todd F.J. Quadrupole Ion Trap Mass Spectrometry. 2nd ed. Vol. 165 (2005), John Wiley & Sons, New York
19. Charles M.J., McLuckey S.A., and Glish G.L. Competition between Resonance Ejection and Ion Dissociation during Resonance Excitation in a Quadrupole Ion Trap. J. Am. Soc. Mass Spectrom. 5 (1994) 1031-1041
20. Kaiser R.E., Cooks R.G., Stafford G.C., Syka J.E.P., and Hemberger P.H. Operation of a Quadrupole Ion Trap Mass-Spectrometer to Achieve High Mass Charge Ratios. Int. J. Mass Spectrom. Ion Process. 106 (1991) 79-115
21. Creaser C.S., and Stygall J.W. A Comparison of Overtone and Fundamental Resonances for Mass Range Extension by Resonance Ejection in a Quadrupole Ion Trap Mass Spectrometer. Int. J. Mass Spectrom. 191 (1999) 145-151
22. McClellan J.E., Murphy J.P., Mulholland J.J., and Yost R.A. Effects of Fragile Ions on Mass Resolution and on Isolation for Tandem Mass Spectrometry in the Quadrupole Ion Trap Mass Spectrometer. Anal. Chem. 74 (2002) 402-412
23. Favre A., Gonnet F., and Tabet J.-C. Perturbation of Ion Trajectories by Resonant Excitation Leads to Occurrence of Ghost Peaks. Rapid Commun. Mass Spectrom. 15 (2001) 446-450
24. Murphy J.P., and Yost R.A. Origin of Mass Shifts in the Quadrupole Ion Trap: Dissociation of Fragile Ions Observed with a Hybrid Ion Trap/Mass Filter Instrument. Rapid Commun. Mass Spectrom. 14 (2000) 270-273
25. Dobson G., Murrell J., Despeyroux D., Wind F., and Tabet J.C. Investigations into the Use of a Reverse Scan in a Quadrupole Ion Trap Mass Spectrometer. Rapid Commun. Mass Spectrom. 17 (2003) 1657-1664
26. Williams J.D., Cox K.A., Cooks R.G., McLuckey S.A., Hart K.J., and Goeringer D.E. Resonance Ejection Ion-Trap Mass-Spectrometry and Nonlinear Field Contributions-The Effect of Scan Direction on Mass Resolution. Anal. Chem. 66 (1994) 725-729
27. Wells J.M., Plass W.A., and Cooks R.G. Control of Chemical Mass Shifts in the Quadrupole Ion Trap through Selection of Resonance Ejection Working Point and rf Scan Direction. Anal. Chem. 72 (2000) 2677-2683
28. Dobson G., Murrell J., Despeyroux D., Wind F., and Tabet J.-C. Investigation into Factors Affecting Precision in Ion Trap Mass Spectrometry Using Different Scan Directions and Axial Modulation Potential Amplitudes. J. Mass Spectrom. 39 (2004) 1295-1304
29. Jackson G.P., King F.L., and Duckworth D.C. Efficient Polyatomic Interference Reduction in Plasma-source Mass Spectrometry via Collision Induced Dissociation. J. Anal. At. Spectrom. 18 (2003) 1026-1032
30. Jackson G.P., Hyland J.J., and Laskay U.A. Energetics and Efficiencies of Collision-induced Dissociation Achieved during the Mass Acquisition Scan in a Quadrupole Ion Trap. Rapid Commun. Mass Spectrom. 19 (2005) 3555-3563
31. Baer T., Dutuit O., Mestdagh H., and Rolando C. Dissociation Dynamics of Normal-Butylbenzene Ions-The Competitive Production of m/z 91-Fragment and 92-Fragment Ions. J. Phys. Chem. 92 (1988) 5674-5679
32. Griffiths I.W., Harris F.M., Mukhtar E.S., and Beynon J.H. Calculation of the Abundance Ratio [91+ 92+] from Normal-Butylbenzene Molecular-Ions as a Function of Internal Energy. Int. J. Mass Spectrom. Ion Process. 41 (1981) 83-88
33. Harrison A.G., and Lin M.S. Energy-dependence of the Fragmentation of the Normal-Butylbenzene Molecular Ion. Int. J. Mass Spectrom. Ion Process. 51 (1983) 353-356
34. Oh S.T., Choe J.C., and Kim M.S. Photodissociation Dynamics of n-Butylbenzene Molecular Ion. J. Phys. Chem. 100 (1996) 13367-13374
35. Plomley J.B., Londry F.A., and March R.E. The Consecutive Fragmentation of n-Butylbenzene in a Quadrupole Ion Trap. Rapid Commun. Mass Spectrom. 10 (1996) 200-203
36. Dawson P.H. Low-energy Collision-activated Dissociation of n-Butylbenzene. Effect of the Electron Energy Used during Parent Ion Formation. Int. J. Mass Spectrom. Ion Process. 63 (1985) 339
37. Liere P., March R.E., Blasco T., and Tabet J.-C. Resonance Excitation in a Quadrupole Ion Trap: Modification of Competing Dissociative Channel Yields. Int. J. Mass Spectrom. Ion Process. 153 (1996) 101-117
38. Chen J.H., Hays J.D., and Dunbar R.C. Competitive 2-Channel Photodissociation of Normal-Butylbenzene Ions in the Fourier-Transform Ion-Cyclotron Resonance Mass-Spectrometer. J. Phys. Chem. 88 (1984) 4759-4764
39. McClave J.T., and Dietrich F.H. Statistics. 3rd ed. (1985), Dellen Publishing Company, San Francisco, CA
40. Bui H.A., and Cooks R.G. Windows Version of the Ion Trap Simulation Program ITSIM: A Powerful Heuristic and Predictive Tool in Ion Trap Mass Spectrometry. J. Mass Spectrom. 33 (1998) 297-304
41. Hart K.J., and McLuckey S.A. Relative Dissociation Energy Measurements Using Ion Trap Collisional Activation. J. Am. Soc. Mass Spectrom. 5 (1994) 250-259
42. Colorado A., and Brodbelt J. An Empirical Approach to Estimation of Critical Energies by Using a Quadrupole Ion Trap. J. Am. Soc. Mass Spectrom. 7 (1996) 1116-1125
43. Vedel F. On the Dynamics and Energy of Ion Clouds Stored in an rf Quadrupole Trap. Int. J. Mass Spectrom. Ion Process. 106 (1991) 33-61
44. Wang M.D., Schachterle S., and Wells G. Application of Nonresonance Excitation to Ion Trap Tandem Mass Spectrometry and Selected Ejection Chemical Ionization. J. Am. Soc. Mass Spectrom. 7 (1996) 668-676
45. Paradisi C., Todd J.F.J., and Vettori U. Comparison of Collisional Activation by the Boundary Effect vs Tickle Excitation in an Ion Trap Mass-Spectrometer. Org. Mass Spectrom. 27 (1992) 1210-1215