Peripheral modulation of dopaminergic receptors affects erectile responses in rats

Basic and Clinical Pharmacology and Toxicology

Volumn 100, Issue 4, 2007, Pages 225-232

  El Din, Mahmoud Mohy ^a   Senbel, Amira M ^a   Daabees, Tahia T ^a   Sharabi, Fouad M ^a  

^a Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; APOMORPHINE; DOPAMINE RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG EFFECT; DRUG MEGADOSE; DRUG SCREENING; EJACULATION; ELECTROSTIMULATION; FEMALE; HYPOTENSION; LOW DRUG DOSE; MALE; MATING; NERVE STIMULATION; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RAT; SEXUAL BEHAVIOR; TACHYCARDIA;

(R)-2,3,4,5-TETRAHYDRO-8-CHLORO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL; ANIMALS; APOMORPHINE; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EJACULATION; ELECTRIC STIMULATION; FEMALE; HEART RATE; INJECTIONS, INTRAVENOUS; MALE; PENILE ERECTION; PENIS; POTASSIUM CHANNEL BLOCKERS; RATS; RECEPTORS, DOPAMINE D1; SEXUAL BEHAVIOR, ANIMAL; SULPIRIDE; TETRAETHYLAMMONIUM; TIME FACTORS;

RATTUS;

EID: 33947264832     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2006.00013.x     Document Type: Article

References (28)

1. Anderson K, Wagner G. Physiology of penile erection. Physiol Rev 1995;75:191-236.
2. Kandeel FR, Koussa VK, Swerdloff S. Male sexual function and its disorders: physiology, clinical investigation, and treatment. Endocr Rev 2001;22:342-88.
3. Lue T, Tanagho EA. Physiology of erection and pharmacological management of impotence. J Urol 1987;137:829-32.
4. Giuliano F, Allard J. Dopamine and male sexual function. Eur Urol 2001;40:601-8.
5. Melis MR, Argiolas A, Gessa GL. Evidence that apomorphine induces penile erection and yawning by releasing oxytocin in the central nervous system. Eur J Pharmacol 1989;164:565-70.
6. Zarrindast MR, Nojoomi K, Sharifzadeh M, Mokri A. Nitric oxide agents and apomorphine-induced rat behaviors. Pharmacology 2004;71:169-73.
7. Melis M, Argiolas A, Gessa GL. Apomorphine-induced penile erection and yawning: site of action in brain. Brain Res 1987;415:98-102.
8. Dula E, Keating W, Siami PF et al. Efficacy and safety of fixed-dose and dose-optimization regimens of sublingual apomorphine versus placebo in men with erectile dysfunction. Urology 2000;56:130-5.
9. Chen K-K, Chan JY, Chang LS. Dopamine neurotransmission at the paraventricular nucleus of hypothalamus in central regulation of penile erection in the rat. J Urol 1999;162:237-42.
10. Giuliano F, Bernabe J, Jardin A, Rousseau JP. Antierectile role of the sympathetic nervous system in rats. J Urol 1993;150:519-24.
11. Tseng CJ, Liu HY, Lin HC, Ger LP, Tung CS, Yen MH. Cardiovascular effects of nitric oxide in the brain stem nuclei of rats. Hypertension 1996;27:36-42.
12. 1-adrenoceptors subtypes on erection in anesthetized rats and dogs. J Pharmacol Exp Ther 2000;292:974-81.
13. Butcher LL, Butcher SG, Larsson K. Effects of apomorphine, amphetamnine, and nialiamide on tetrabenazine-induced suppression of sexual behavior in the male rat. Eur J Pharmacol 1969;7:283-8.
14. 2 receptors in rat corpus cavernosum. BJU Int 2002;90:105-11.
15. Hurst RS, Higdon NR, Lawson JA et al. Dopamine receptor agonists differ in their actions on cardiac ion channels. Eur J Pharmacol 2003;482:31-7.
16. 2 receptors and KCNQ channels. Pflugers Arch 2003;446:684-94.
17. Dong Y, Coope D, Nasil F, Hu XT, White FJ. Dopamine modulates inwardly rectifying potassium currents in medial prefrontal cortex pyramidal neurons. J Neurosci 2004;24:3077-85.
18. 1 selective receptor agonist in human corpus cavernosum strips. Int J Impot Res 2005;17:127- 33.
19. Pehek EA, Thompson JT, Eaton RC, Bazzett TJ, Hull EM. Apomorphine and haloperidol, but not domperidone, affect penile reflexes in rats. Pharmacol Biochem Behav 1988;31:201-8.
20. Andersson K-E, Gemalmaz H, Waldeck K, Chapman TN, Tuttle JB, Steers WD. The effect of sildenafil on apomorphine-evoked increases in intracavernous pressure in the awake rat. J Urol 1999;161:1707-12.
21. 2 receptors on genital reflexes: implications for copulation. Life Sci 1992;51:1705-13.
22. Kopia GA, Valocik RE. Demonstration of specific dopamine-1 receptor-mediated coronary vasodilation in the anaesthetized dog. J Pharmacol Exp Ther 1989;248:215-21.
23. Ishizuka O, Gu B-J, Nishizawa O, Mizusawa H, Andersson K-E. Effect of apomorphine on intracavernous pressure and blood pressure in conscious, spinalized rats. Int J Impot Res 2002;14:128-32.
24. Park J-Y, Son H, Kim SW, Paick J-S. Potentiation of apomorphine effect on sildenafil-induced penile erection in conscious rabbits. Asian J Androl 2004;6:205-9.
25. Vogel HP, Schiffter R. Hypersexuality - a complication of dopaminergic therapy in Parkinson's disease. Pharmacopsychiatry 1983;16:107-10.
26. 2 receptors. Neurosci Lett 2003;349:115-9.
27. 2 receptor agonists and antagonists. J Cardiovasc Pharmacol 1991;18:548- 55.
28. Bowron A. Practical considerations in the use of apomorphine injectable. Neurology 2004;62:S32-6.