A microstructure heat exchanger for quenching the metabolism of mammalian cells

Chemical Engineering and Technology

Volumn 30, Issue 3, 2007, Pages 322-328

  Wiendahl, C ^a   Brandner, J J ^b   Kuppers C ^a   Lu, B ^a   Schygulla, U ^b   Noll, T ^c   Oldiges, M ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^c BIELEFELD UNIVERSITY   (Germany)

Author keywords

Heat transfer; Metabolome analysis; Microstructure heat exchanger; Quenching

Indexed keywords

CELLS; COOLING; METABOLISM; METABOLITES; THERMAL EFFECTS;

INTRACELLULAR METABOLITES; METABOLOMICS; MICROSTRUCTURE HEAT EXCHANGER;

HEAT EXCHANGERS;

CELLS; COOLING; HEAT EXCHANGERS; METABOLISM; METABOLITES; THERMAL EFFECTS;

MAMMALIA;

EID: 33947256108     PISSN: 09307516     EISSN: 15214125     Source Type: Journal    
DOI: 10.1002/ceat.200600362     Document Type: Conference Paper

References (25)

1. S. Farid, Adv. Biochem. Eng. Biotechnol. 2006, 101, 1.
2. O.-W. Merten, Cytotechnology 2006, 50 (1-3), 1.
3. H. J. Cruz, J. L. Moreira, M. J. T. Carrondo, Biotechnol. Bioeng. 1999, 66 (2), 104.
4. N. S. Forbes, D. S. Clark, H. W. Blanch, Analysis of Metabolic Flux in Mammalian Cells (Eds: K. Schügerl, K. H. Bellgardt), in Bioreaction Engineering, Springer, Heidelberg 2000.
5. C. Altamirano, A. Illanes, A. Casablancas, X. Gamez, et al., Biotechnol. Progress 2001, 17 (6), 1032.
6. B. H. Chun, S. Y. Park, N. Y. Chung, W. G. Bang, Biotechnol. Lett. 2003, 25 (4), 315.
7. S. R. Fox, U. A. Patel, M. G. S. Yap, D. I. C. Wang, Biotechnol. Bioeng. 2004, 85 (2), 177.
8. H. Kaufmann, X. Mazur, M. Fussenegger, J. E. Bailey, Biotechnol. Bioeng. 1999, 63 (5), 573.
9. M. S. Kim, N. S. Kim, Y. H. Sung, G. M. Lee, In Vitro Cell. Develop. Biol. - Animal 2002, 38 (6), 314.
10. M. S. Lee, G. M. Lee, Biotechnol. Bioeng. 2000, 68 (3), 260.
11. J. Kruh, Mol. Cell. Biochem. 1982, 42 (2), 65.
12. S. G. Villas-Boas, S. Mas, M. Akesson, J. Smedsgaard, et al., Mass Spectrometry Rev. 2005, 24 (5), 613.
13. S. G. Villas-Boas, S. Rasmussen, G. A. Lane, Trends Biotechnol. 2005, 23 (8), 385.
14. H. A. Hansen, C. Emborg, Appl. Microbiol. Biotechnol. 1994, 41 (5), 560.
15. G. Schmid, T. Keller, Cytotechnology 1992, 9 (1-3), 217.
16. N. Kockmann, Micro Process Engineering (Eds: O. Brand, G. K. Fedder, C. Hierold, J. G. Korvink, O. Tabata), Advanced Micro and Nanosystems, Vol. 5, Wiley-VCH, Weinheim 2006.
17. J. J.Brandner, K. Schubert, Fabrication and Testing of Microstructure Heat Exchangers for Thermal Applications, in 3rd Int. Conf. on Micro- and Minichannels, Toronto, Canada, 2005.
18. K. Schubert, J. Brandner, M. Fichtner, G. Linder, et al., Microscale Thermophys. Eng. 2001, 5 (1), 17.
19. V. Hessel, H. Löwe, A. Müller, G. Kolb, Chemical Micro Process Engineering, Wiley-VCH, Weinheim 2005.
20. T. Schaller, W. Bier, G. Lindner, K. Schubert, F&M Feinwerk Mechanik 1994, 102 (5-6).
21. T. Schaller, L. Bohn, J. Mayer, K. Schubert, Precision Eng. - J. of Am. Soc. for Precision Engineering 1999, 23 (4), 229.
22. M. Madou, Fundamentals of Microfibration, 2nd ed, CRS Press LLC, Boca Raton, FL, USA, 2002.
23. J. J. Brandner, et al. Comparison of Crossflow Micro Heat Exchangers with Different Microstructure Designs, in 3rd Int. Conf. on Micro- and Minichannels, Toronto, Canada, 2005.
24. VDI Wärmeatlas, 7th ed., VDI-Verlag, Würzburg, Germany, 1994.
25. W. Wagner, Wärmeaustauscher, 2nd ed., Vogel-Verlag, Würzburg, Germany, 1999.