Attenuated pulse size, disorderly growth hormone and prolactin secretion with preserved nyctohemeral rhythm distinguish irradiated from surgically treated acromegaly patients

Clinical Endocrinology

Volumn 66, Issue 4, 2007, Pages 489-498

  Van Der Klaauw, A A ^a   Pereira, A M ^a   Van Thiel, S W ^a   Frolich, M ^a   Iranmanesh, A ^b   Veldhuis, J D ^c   Roelfsema, F ^a   Romijn, J A ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; PROLACTIN; SOMATOMEDIN C;

ACROMEGALY; ADULT; ANALYTIC METHOD; ARTICLE; CIRCADIAN RHYTHM; CLUSTER ANALYSIS; CONTROLLED STUDY; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HORMONE BLOOD LEVEL; HORMONE SUBSTITUTION; HUMAN; HYPOPHYSIS FUNCTION; INSULIN TOLERANCE TEST; IRRADIATION; PRIORITY JOURNAL; PROLACTIN RELEASE; SAMPLING;

ACROMEGALY; CASE-CONTROL STUDIES; CIRCADIAN RHYTHM; COMBINED MODALITY THERAPY; FEMALE; GROWTH HORMONE; HUMANS; HYPOPHYSECTOMY; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; PITUITARY GLAND; POSTOPERATIVE PERIOD; PROLACTIN; SECRETORY RATE; TREATMENT OUTCOME;

EID: 33947227511     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2006.02757.x     Document Type: Article

References (49)

1. Hartman, M.L., Veldhuis, J.D., Vance, M.L., Faria, A.C., Furlanetto, R.W. & Thorner, M.O. (1990) Somatotropin pulse frequency and basal concentrations are increased in acromegaly and are reduced by successful therapy. Journal of Clinical Endocrinology and Metabolism, 70, 1375-1384.
2. Hartman, M.L., Pincus, S.M., Johnson. M.L., Mattwhews, D.H., Faunt, L.M., Vance, M.L., Thorner, M.O. & Veldhuis, J.D. (1994) Enhanced basal and disorderly growth hormone secretion distinguish acromegalic from normal pulsatile growth hormone release. Journal of Clinical Investigation, 94, 1277-1288.
3. Ho, K.Y. & Weissberger, A.J. (1994) Characterization of 24-hour growth hormone secretion in acromegaly: implications for diagnosis and therapy. Clinical Endocrinology, 41, 75-83.
4. van den Berg, G., Frolich. M., Veldhuis, J.D. & Roelfsema, F. (1994) Growth hormone secretion in recently operated acromegalic patients. Journal of Clinical Endocrinology and Metabolism, 79, 1706-1715.
5. van den Berg, G., Pincus, S.M., Frolich, M., Veldhuis, J.D. & Roelfsema, F. (1998) Reduced disorderliness of growth hormone release in biochemically inactive acromegaly after pituitary surgery. European Journal of Endocrinology, 138, 164-169.
6. Biermasz, N.R., Pereira, A.M., Frolich, M., Romijn, J.A., Veldhuis, J.D. & Roelfsema, F. (2004) Octreotide represses secretory-burst mass and nonpulsatile secretion but does not restore event frequency or orderly GH secretion in acromegaly. American Journal of Physiology. Endocrinology and Metabolism, 286, E25-E30.
7. Darzy, K.H. & Shalet, S.M. (2005) Hypopituitarism after cranial irradiation. Journal of Endocrinological Investigation, 28, 78-87.
8. Littley, M.D., Shalet, S.M., Beardwell, C.G., Ahmed, S.R., Applegate, G. & Sutton, M.L. (1989) Hypopituitarism following external radiotherapy for pituitary tumours in adults. Quarterly Journal of Medicine, 70, 145-160.
9. Biermasz, N.R., van Dulken, H. & Roelfsema, F. (2000) Long-term follow-up results of postoperative radiotherapy in 36 patients with acromegaly. Journal of Clinical Endocrinology and Metabolism, 85, 2476-2482.
10. Conceicao, F.L., Fisker, S., Andersen, M., Kaal, A., Jorgenson, J.O., Vaisman, M. & Christiansen, J.S. (2003) Evaluation of growth hormone stimulation tests in cured acromegalic patients. Growth Hormone and IGF Research, 13, 347-352.
11. Murray, R.D., Peacey, S.R., Rahim, A., Toogood, A.A., Thorner, M.O. & Shalet, S.M. (2001) The diagnosis of growth hormone deficiency (GHD) in successfully treated acromegalic patients. Clinical Endocrinology, 54, 37-44.
12. Peacey, S.R., Toogood, A.A. & Shalet, S.M. (1998) Hypothalamic dysfunction in 'cured' acromegaly is treatment modality dependent. Journal of Clinical Endocrinology and Metabolism, 83, 1682-1686.
13. Peacey, S.R., Toogood, A.A., Veldhuis, J.D., Thorner, M.O. & Shalet, S.M. (2001) The relationship between 24-hour growth hormone secretion and insulin-Iike growth factor I in patients with successfully treated acromegaly: impact of surgery or radiotherapy. Journal of Clinical Endocrinology and Metabolism, 86, 259-266.
14. Bates, A.S., Van t'Hoff, N., Jones, J.M. & Clayton, R.M. (1993) An audit of outcome of treatment in acromegaly. Quarterly Journal of Medicine, 86, 293-299.
15. Mukherjee, A., Murray, R.D., Columb, B., Gleeson, H.K. & Shalet, S.M. (2003) Acquired prolactin deficiency indicates severe hypopituitarism in patients with disease of the hypothalamic-pituitary axis. Clinical Endocrinology, 59, 743-748.
16. Biermasz, N.R., van Dulken, H. & Roelfsema, F. (2000) Ten-year follow-up results of transsphenoidal microsurgery in acromegaly. Journal of Clinical Endocrinology and Metabolism, 85, 4596-4602.
17. Growth Hormone Research Society (1998) Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency. Journal of Clinical Endocrinology and Metabolism, 83, 379-381.
18. Veldhuis, J.D. & Johnson, M.L. (1992) Deconvolution analysis of hormone data. Methods in Enzymology, 210, 539-575.
19. Pincus, S.M., Keefe, D. & L. (1992) Quantification of hormone pulsatility via an approximate entropy algorithm. American Journal of Physiology. Endocrinology and Metabolism, 262, E741-E754.
20. Veldhuis, J.D. & Pincus, S.M. (1998) Orderliness of hormone release patterns: a complementary measure to conventional pulsatile and circadian analyses. European Journal of Endocrinology, 138, 358-362.
21. Groote Veldman, R., van den Berg, G., Pincus, S.M., Frolich, M., Veldhuis, J.D. & Roelfsema, F. (1999) Increased episodic release and disorderliness of prolactin secretion in both micro- and macroprolactinomas. European Journal of Endocrinology, 140, 192-200.
22. van den Berg, G., Pincus, S.M., Veldhuis, J.D., Frolich, M. & Roelfsema, F. (1997) Greater disorderliness of ACTH and cortisol release accompanies pituitary-dependent Cushing's disease. European Journal of Endocrinology, 136, 394-400.
23. Veldhuis, J.D., Straume, M., Iranmanesh, A., Mulligan, T., Jaffe, C., Barkan, A., Johnson, M.L. & Pincus, S. (2001) Secretory process regularity monitors neuroendocrine feedback and feedforward signaling strength in humans. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 280, R721-R729.
24. Veldhuis, J.D. & Johnson, M.L. (1986) Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection. American Journal of Physiology. Endocrinology and Metabolism, 250, E486-E493.
25. Iranmanesh, A., South, S., Liem, A.Y., Clemmons, D., Thorner, M.O., Weltman, A. & Veldhuis, J.D. (1998) Unequal impact of age, percentage body fat, and serum testosterone concentration on the somatotrophic, IGF-I, and and IGF-binding protein responses to a three-day intravenous growth hormone-releasing pulsatile infusion in men. European Journal of Endocrinology, 139, 59-71.
26. Veldhuis, J.D., Iranmanesh, A. & Bowers, C.Y. (2005) Joint mechanisms of impaired growth hormone pulse renewal in aging men. Journal of Clinical Endocrinology and Metabolism, 90, 4177-4183.
27. Giustina, A. & Veldhuis, J.D. (1998) Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocrine Reviews, 19, 717-797.
28. Farhy, L.S., Straume, M., Johnson, M.L., Kovatchev, B. & Veldhuis, J.D. (2001) A construct of interactive feedback control of the GH axis in the male. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 281, R38-R51.
29. Farhy, L.S., Straume, M., Johnson, M.L., Kovatchev, B. & Veldhuis, J.D. (2002) Unequal autonegative feedback by GH models the sexual dimorphism in GH secretory dynamics. American Journal of Physiology Regulatory, Integrative and Comparative Physiology, 282, R753-R764.
30. Farhy, L.S. & Veldhuis, J.D. (2005) Deterministic construct of amplifying action of ghrelin on pulsatile growth hormone secretion. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 288, R1649-R1663.
31. Alba-Roth, J., Muller, O.A., Schopol, J. & von Werder, K. (1988) Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. Journal of Clinical Endocrinology and Metabolism, 67, 1186-1189.
32. Masuda, A., Shibasaki, T., Hotta, M., Yamauchi, M., Ling, N., Demura, H. & Shizumek, K. (1990) Insulin-induced hypoglycemia, 1-dopa and arginine stimulate GH secretion through different mechanisms in man. Regulatory Peptides, 29, 53-64.
33. Darzy, K.H., Pezzoli, S.S.R., Thorner, M.O. & Shalet, S.M. (2005) The dynamics of growth hormone (GH) secretion in adult cancer survivors with severe GH deficiency acquired after brain irradiation in childhood for nonpituitary brain tumors: evidence for preserved pulsatility and diurnal variation with increased secretory disorderliness. Journal of Clinical Endocrinology and Metabolism, 90, 2794-2803.
34. Roelfsema, F., Biermasz, N.R. & Veldhuis, J.D. (2002) Pulsatile, nyctohemeral and entropic characteristics of GH secretion in adult GH-deficient patients: selectively decreased pulsatile release and increased secretory disorderliness with preservation of diurnal timing and gender distinctions. Clinical Endocrinology, 56, 79-87.
35. Mukherjee, A., Rijder, W.D., Jostel, A. & Shalet, S.M. (2006) Prolactin deficiency is independently associated with reduced IGF-I status in severely GHD adults. Journal of Clinical Endocrinology and Metabolism, 91, 2520-2525.
36. Freeman, M.E., Kanyicska, B., Lerant, A. & Nagy, G. (2000) Prolactin: structure, function, and regulation of secretion. Physiological Reviews, 80, 1523-1631.
37. Arita, J., Kojima, Y. & Kimura, F. (1991) Identification by the sequential cell immunoblot assay of a subpopulation of rat dopamine-unresponsive lactotrophs. Endocrinology, 128, 1887-1894.
38. Boockfor, F.R. & Frawley, L.S. (1987) Functional variations among prolactin cells from different pituitary regions. Endocrinology, 120, 874-879.
39. Waldstreicher, J., Duffy, J.F., Brown, E.N., Rogacz, S., Allan, J.S. & Czeisler, C.A. (1996) Gender differences in the temporal organization of proclactin (PRL) secretion: evidence for a sleep-independent circadian rhythm of circulating PRL levels- a clinical research center study. Journal of Clinical Endocrinology and Metabolism, 81, 1483-1487.
40. Nagy, E. & Berczi, I. (1991) Hypophysectomized rats depend on residual prolactin for survival. Endocrinology, 128, 2776-2784.
41. Ben Jonathan, N., Mershon, J.L., Allen, D.L. & Steinmetz, R.W. (1996) Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects. Endocrine Reviews, 17, 639-669.
42. Veldman, R.G., Frolich, M., Pincus, S.M., Veldhuis, J.D. & Roelfsema, F. (2001) Basal, pulsatile, entropic, and 24-hour rhythmic features of secondary hyperprolactinemia due to functional pituitary stalk disconnection mimic tumoral (primary) hyperprolactinemia. Journal of Clinical Endocrinology and Metabolism, 86, 1562-1567.
43. Shalet, S.M., Toogood, A., Rahim, A., Brennan, B. & M. (1998) The diagnosis of growth hormone deficiency in children and adults. Endocrine Reviews, 19, 203-223.
44. Corneli, G., DiSomma, C., Baldelli, R., Rovere, S., Gasco, V., Groce, C.G., Grottoli, S., Maccario, M., Colao, A., Lombardi, G., Ghigo, E., Camanni, F. & Aimaretti, G. (2005) The cut-off limits of the GH response to GH-releasing hormone-arginine test related to body mass index. European Journal of Endocrinology, 153, 257-264.
45. Pekic, S., Doknic, M., Miljic, D., Joksimovic, M., Glodic, J., Djurovic, M., Dieguez, C., Casanueva, F. & Popovic, V. (2006) Ghrelin test for the assessment of GH status in successfully treated patients with acromegaly. European Journal of Endocrinology, 91, 1491-1495.
46. Ghigo, E., Aimaretti, G., Arvas, G. & Camanni, F. (2001) Growth hormone-releasing hormone combined with arginine or growth hormone secretagogues for the diagnosis of growth hormone deficiency in adults. Endocrine, 15, 29-38.
47. Popovic, V., Leal, A., Micic, D., Koppeschaar, H.F., Torres, E., Paramo, C., Obradovic, S., Dieguez, C. & Casanueva, F.F. (2000) GH-releasing hormone and GH-releasing peptide-6 for diagnostic testing in GH-deficient adults. Lancet, 356, 1137-1142.
48. Hoffman, D.H., O'Sullivan, A.J., Baxter, R.C. & Ho, K.K. (1994) The diagnosis of growth hormone deficiency in adults. Lancet, 343, 1064-1068.
49. Reutens, A.T., Hoffman, D.M., Leung, K.C. & Ho, K.K. (1995) Evaluation and application of a highly sensitive assay for serum growth hormone (GH) in the study of adult GH deficiency. Journal of Clinical Endocrinology and Metabolism, 80, 480-485.