Fatty acid turnover, substrate oxidation, and heat production in lean and obese cats during the euglycemic hyperinsulinemic clamp

Domestic Animal Endocrinology

Volumn 32, Issue 4, 2007, Pages 329-338

  Hoenig, M ^a   Thomaseth, K ^b   Waldron, M ^c   Ferguson, D C ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b CNR   (Italy)

^c NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

Cats; Diabetes; Euglycemic hyperinsulinemic clamp; Indirect calorimetry; Obesity

Indexed keywords

FATTY ACID; INSULIN;

ADAPTATION; ANIMAL; ARTICLE; CALORIMETRY; CAT; COMPARATIVE STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HYPERINSULINISM; MALE; METABOLISM; OBESITY; OXIDATION REDUCTION REACTION; PHYSIOLOGY; SEX DIFFERENCE; STATISTICAL ANALYSIS; THERMOGENESIS;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BLOOD GLUCOSE; CALORIMETRY, INDIRECT; CATS; FATTY ACIDS; FEMALE; GLUCOSE CLAMP TECHNIQUE; HYPERINSULINISM; INSULIN; MALE; MATCHED-PAIR ANALYSIS; OBESITY; OXIDATION-REDUCTION; SEX FACTORS; THERMOGENESIS;

EID: 33947225232     PISSN: 07397240     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.domaniend.2006.04.003     Document Type: Article

References (44)

1. Lewis G.F., Carpentier A., Adeli K., and Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 23 (2002) 201-229
2. Hoenig M., Wilkins C., Holson J., and Ferguson D.C. Effect of obesity on lipid profiles in neutered male and female cats. Am J Vet Res 64 (2003) 299-303
3. Wilkins C.E., Long Jr. R.C., Waldron M., Ferguson D.C., and Hoenig M. Assessment of the influence of fatty acids on indices of insulin sensitivity and myocellular lipid content by use of magnetic resonance spectroscopy in cats. Am J Vet Res 65 (2004) 1090-1099
4. Hoenig M, Thomaseth K, Brandao J, Waldron M, Ferguson DC. Assessment and mathematical modeling of glucose turnover and insulin sensitivity in lean and obese cats. Dom Anim Endocrinol, in press.
5. Kleiber M. The fire of life. An introduction to animal energetics (1975), Robert E. Krieger publishing company, Huntington, New York
6. Boden G., and Shulman G.I. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β-cell dysfunction. Eur J Clin Invest 32 (2002) 14-23
7. Boden G., Chen X., Ruiz J., White J.V., and Rosetti L. Mechanism of fatty acid induced inhibition of glucose uptake. J Clin Invest 93 (1994) 2438-2446
8. Battezzati A., and Vigano R. Indirect calorimetry and nutritional problems in clinical practice. Acta Diabetol 38 (2001) 1-5
9. Simonson D.C., and DeFronzo R.A. Indirect calorimetry: methodological and interpretative problems. Am J Physiol 258 (1990) E399-E412
10. Ferannini E. The theoretical basis of indirect calorimetry: a review. Metabolism 37 (1988) 287-301
11. Hoenig M., and Ferguson D.C. Impairment of glucose tolerance in hyperthyroid cats. J Endocrinol 121 (1989) 249-251
12. Hoenig M., McGoldrick J.B., deBeer M., Demacker P.N.M., and Ferguson D.C. Activity and tissue-specific expression of lipases and tumor-necrosis factor α in lean and obese cats. Dom Anim Endocrinol 30 (2006) 333-344
13. Kelley D.E., and Mandarino L.J. Fuel selection in human skeletal muscle in insulin resistance. A reexamination. Diabetes 49 (2000) 677-683
14. Kelley D.E., Goodpaster B., Wing R.R., and Simoneau J.A. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol Endocrinol Metab 277 (1999) E1130-E1141
15. Felber J.P., Ferranini E., Golay A., Meyer H., Theibauld B., Curchod B., et al. Role of lipid oxidation in the pathogenesis of insulin resistance of obesity and type II diabetes. Diabetes 36 (1987) 1341-1350
16. Tataranni P.A., lason D.E., and Ravussin E. Body fat distribution and energy metabolism in obese men and women. J Am Coll Nutr 13 (1994) 569-574
17. Weyer C., Snitker S., Rising R., Bogardus C., and Ravussin E. Determinants of energy expenditure and fuel utilization in man: effects of body composition, age, sex, ethnicity, and glucose tolerance in 916 subjects. Int J Obes Relat Metab Disord 23 (1999) 715-722
18. Goodpaster B.H., Katsiaras A., and Kelley D.E. Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. Diabetes 52 (2003) 2191-2197
19. Zurlo F., Lillioja S., Esposito-Del Puente A., Nyomba B.L., Raz I., Saad M.F., et al. Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am J Physiol 259 (1990) E650-E657
20. Seidell J.C., Muller D.C., Sorkin J.D., and Andres R. Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: the Baltimore Longitudinal Study on aging. Int J Obes Relat Metab Disord 16 (1992) 667-674
21. Venables M.C., Achten J., and Jeukendrup A.E. Determinants of fat oxidation during exercise in healthy men and women: a cross sectional study. J Appl Physiol 27 (2003) 662-692
22. Williams C.M. Lipid metabolism in women. Proceedings of the Nutrition Society, vol. 63 (2004) 153-160
23. Randle P.J. Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diab Metab Rev 14 (1998) 263-283
24. Brennan C.L., Hoenig M., and Ferguson D.C. GLUT4 but not GLUT1 expression decreases early in the development of feline obesity. Domest Anim Endocrinol 26 (2004) 291-301
25. Kooner J.S., Baliga R.R., Wilding J., Crook D., Packard C.J., Banks L.M., et al. Abdominal obesity, impaired nonesterified fatty acid suppression, and insulin-mediated glucose disposal are early metabolic abnormalities in families with premature myocardial infarction. Arterioscler Thromb Vasc Biol 18 (1998) 1021-1026
26. Ravussin E., Bogardus C., Schwartz R.S., Robbins D.C., Wolfe R.R., Horton E.S., et al. Thermic effect of infused glucose and insulin in man. Decreased response with increase insulin resistance in obesity and non insulin dependent diabetes mellitus. J Clin Invest 72 (1983) 893-902
27. Pedersen S.B., Borglum J.D., Schmitz O., Bak J.F., Sorensen N.S., and Richelsen B. Abdominal obesity is associated with insulin resistance and reduced glycogen synthetase activity in skeletal muscle. Metabolism 42 (1993) 998-1005
28. Despres J.P. Abdominal obesity as important component of insulin-resistance syndrome. Nutrition 9 (1993) 452-459
29. Evans D.J., Murray R., and Kissebah A.H. Relationship between skeletal muscle insulin resistance, insulin-mediated glucose disposal, and insulin binding: effects of obesity and body fat topography. J Clin Invest 74 (1984) 1515-1525
30. Groop L.C., Bonadonna R.C., DelPrato S., Ratheiser K., Zyck K., Ferrannini E., et al. Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus: evidence for multiple sites of insulin resistance. J Clin Invest 84 (1989) 205-213
31. Kanety H., Moshe S., Shafrir E., Lunenfeld B., and Karasik A. Hyperinsulinemia induces a reversible impairment in insulin receptor function leading to diabetes in the sand rat model of non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 91 (1994) 1853-1857
32. Castro Cabezas M., de Bruin T.W., de Valk H.W., Shoulders C.C., Jansen H., and Willem Erkelens D. Impaired fatty acid metabolism in familial combined hyperlipidemia: a mechanism associating hepatic apolipoprotein B overproduction and insulin resistance. J Clin Invest 92 (1993) 160-168
33. Aitman T.J., Godsland I.F., Farren B., Crook D., Wong H.J., and Scott J. Defects of insulin action on fatty acid and carbohydrate metabolism in familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol 17 (1997) 748-754
34. Sumner A.E., Kushner H., Tulenko T.N., Falkner B., and Marsh J.B. The relationship in African-Americans of sex differences in insulin-mediated suppression of nonesterified fatty acids to sex differences in fasting triglyceride levels. Metabolism 46 (1997) 400-405
35. Segal K.R., Gutin B., Albu J., and Pi-Sunyer F.X. Thermic effects of food and exercise in lean and obese men of similar lean body mass. Endocrinol Metab 15 (1987) E110-E117
36. Feling P., Cunningan J., Levitt M., Hendler M., and Nadel E. Energy expenditure in obesity in fasting and postprandial state. Endocrinol Metab 7 (1983) E45-E51
37. Ravussin E., and Bogardus C. Thermogenic response to insulin and glucose infusions in man: a model to evaluate the different components of the thermic effect of carbohydrate. Life Sci 31 (1982) 2011-2018
38. Huang K.C., Kormas N., Steinbeck K., Loughman G., and Caterson I.D. Resting metabolic rate in severely obese diabetic and nondiabetic subjects. Obes Res 12 (2004) 840-845
39. Schrauwen P., Walder K., and Ravussin E. Human uncoupling proteins and obesity. Obes Res 7 (1999) 97-105
40. Schrauwen P., and Hesselink M. UCP2 and UCP3 in muscle controlling body metabolism. J Exp Biol 205 (2002) 2275-2285
41. Weyer C., Bogardus C., and Pratley R.E. Metabolic factors contributing to increased resting metabolic rate and decreased insulin induced thermogenesis during the development of type 2 diabetes. Diabetes 48 (1999) 1607-1614
42. James W.P.T., Davies H.L., Bailes J., and Dauncey M.J. Elevated metabolic rates in obesity. Lancet 2 (1978) 1122-1125
43. Bogardus C., Taskinen M.-R., Zawadzki J., Lillioja S., Mott D., and Howard B.V. Increased resting metabolic rates in obese subjects with non-insulin dependent diabetes mellitus and the effect of sulfonylurea therapy. Diabetes 35 (1986) 1-5
44. Golay A., Schutz Y., Meyer H.U., Thiebaud D., Curchod B., Maeder E., et al. Glucose-induced thermogenesis in non-diabetic and diabetic obese subjects. Diabetes 31 (1982) 1023-1028